MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Disruption of epithelial cell-matrix interactions induces apoptosis

1994 • 3,167 citations

An estrogen-responsive element derived from the 5′ flanking region of the Xenopus vitellogenin A2 gene functions in transfected human cells

1986 • 729 citations

Estrogen receptor as an independent prognostic factor for early recurrence in breast cancer.

1977 • 694 citations

A secreted glycoprotein induced by estrogen in human breast cancer cell lines

1980 • 481 citations

A synthetic peptide substrate for selective assay of protein kinase C

1990 • 292 citations

Protein kinase C — a family affair

1989 • 289 citations

Effect of phorbol esters on protein kinase C-zeta.

1992 • 282 citations

Specific expression of the pS2 gene in subclasses of breast cancers in comparison with expression of the estrogen and progesterone receptors and the oncogene ERBB2.

1987 • 279 citations

The epsilon isoform of protein kinase C is an oncogene when overexpressed in rat fibroblasts.

1993 • 222 citations

Elevated protein kinase C expression in human breast tumor biopsies relative to normal breast tissue.

1989 • 211 citations

Phase I Study of Bryostatin 1: Assessment of Interleukin 6 and Tumor Necrosis Factor Induction In Vivo

1993 • 185 citations

Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha.

1993 • 166 citations

A phase I study of intravenous bryostatin 1 in patients with advanced cancer

1993 • 147 citations

Transfection with Protein Kinase Cα Confers Increased Multidrug Resistance to MCF-7 Cells Expressing P-Glycoprotein

1991 • 146 citations

Mutagenesis of the pseudosubstrate site of protein kinase C leads to activation

1990 • 144 citations

Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells.

1993 • 133 citations

The role of cathepsin D in the invasiveness of human breast cancer cells.

1993 • 132 citations

Molecular and cellular analysis of basement membrane invasion by human breast cancer cells in Matrigel-basedin vitro assays

1993 • 122 citations

Vimentin—a new prognostic parameter in breast carcinoma?

1989 • 117 citations

Predominant expression of nPKC eta, a Ca(2+)-independent isoform of protein kinase C in epithelial tissues, in association with epithelial differentiation.

1993 • 108 citations

Cathepsin D in breast cancer

1990 • 106 citations

Differential effects of bryostatin 1 and phorbol ester on human breast cancer cell lines.

1992 • 104 citations

Elevated level of nuclear protein kinase C in multidrug-resistant MCF-7 human breast carcinoma cells.

1992 • 94 citations

Inhibition of Estrogen Receptor Activity by the Tumor Promoter 12-O-Tetradeconylphorbol-13-Acetate: A Molecular Analysis

1991 • 94 citations

Co‐expression of cytokeratin and vimentin intermediate filament proteins in benign and neoplastic breast epithelium

1989 • 93 citations

Quantitative demonstration of spontaneous metastasis by MCF-7 human breast cancer cells cotransfected with fibroblast growth factor 4 and LacZ.

1993 • 93 citations

Post-transcriptional destabilization of estrogen receptor mRNA in MCF-7 cells by 12-O-tetradecanoylphorbol-13-acetate.

1991 • 88 citations

Immunological quantitation of phospholipid/CA²⁺‐dependent protein kinase of human mammary carcinoma cells: Inverse relationship to estrogen receptors

1987 • 86 citations

Influence of 12-O-tetradecanoylphorbol-13-acetate on proliferation and maturation of human breast carcinoma cells (MCF-7): relationship to cell cycle events.

1987 • 75 citations

Inhibition of MCF-7 cell growth by 12-O-tetradecanoylphorbol-13-acetate and 1,2-dioctanoyl-sn-glycerol: distinct effects on protein kinase C activity.

1988 • 71 citations

Failure of wild-type or a mutant form of protein kinase C-α to transform fibroblasts

1991 • 68 citations

Protein kinase C desensitization by phorbol esters and its impact on growth of human breast cancer cells

1986 • 62 citations

Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters.

1992 • 58 citations

Association of mRNA and eIF-2α with the cytoskeleton in cells lacking vimentin

1989 • 46 citations

Down-Regulation of Messenger Ribonucleic Acid and Protein Levels for Estrogen Receptors by Phorbol Ester and Calcium in MCF-7 Cells*

1991 • 37 citations

Hyperinducible gene expression from a metallothionein promoter containing additional metal-responsive elements

1989 • 37 citations

Modulation of protein kinase C-epsilon by phorbol esters in the monoblastoid U937 cell.

1992 • 31 citations

Effects of phorbol esters on an interleukin-3-dependent cell line

1990 • 25 citations

Molecular and cellular analysis of basement membrane invasion by human breast cancer cells in Matrigel-based in vitro assays

1993 • 6 citations

Effects of phorbol esters on an interleukin-3-dependent cell line

1990 • 3 citations

Flow Cytometry in the Management of Breast Cancer

1989 • 2 citations