Activation of H-ras61L-Specific Signaling Pathways Does Not Require Posttranslational Processing of H-ras

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

PROTEIN PRENYLATION: Molecular Mechanisms and Functional Consequences

1996 • 1,977 citations

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

1994 • 1,005 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

1989 • 881 citations

Small GTP-Binding Proteins and the Regulation of the Actin Cytoskeleton

1994 • 822 citations

Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton

1997 • 802 citations

Endomembrane Trafficking of Ras

1999 • 753 citations

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

1985 • 738 citations

Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation

1995 • 683 citations

Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

1993 • 668 citations

Role of Lipid Modifications in Targeting Proteins to Detergent-resistant Membrane Rafts

1999 • 626 citations

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation.

1995 • 609 citations

The p21 ras C-terminus is required for transformation and membrane association

1984 • 590 citations

A role for Rho in Ras transformation.

1995 • 538 citations

Three-Dimensional Structure of an Oncogene Protein: Catalytic Domain of Human c-H- ras P21

1988 • 532 citations

PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity

1992 • 480 citations

A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity

1998 • 471 citations

Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis.

1989 • 462 citations

Ras C-terminal processing enzymes—New drug targets?

1991 • 461 citations

Post-translational modifications of p21rho proteins.

1992 • 422 citations

Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo.

1988 • 404 citations

Raf-1 Kinase Possesses Distinct Binding Domains for Phosphatidylserine and Phosphatidic Acid

1996 • 402 citations

Intracellular localization of the P21rho proteins.

1992 • 382 citations

c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK

1994 • 350 citations

Protein Prenylation: a Mediator of Protein-Protein Interactions

1993 • 346 citations

Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase.

1993 • 345 citations

Golgi localization of glycosyltransferases: more questions than answers

1997 • 323 citations

The dynamic role of palmitoylation in signal transduction

1995 • 315 citations

The mitogen-activated protein kinase activator

1992 • 285 citations

Four Human Ras Homologs Differ in Their Abilities to Activate Raf-1, Induce Transformation, and Stimulate Cell Motility

1999 • 285 citations

Rho family GTPases: the cytoskeleton and beyond

1996 • 262 citations

Membrane Association and Targeting of Prenylated Ras-like GTPases

1998 • 259 citations

Critical role of Rho in cell transformation by oncogenic Ras.

1995 • 256 citations

Ras Farnesyltransferase: A New Therapeutic Target

1997 • 236 citations

Convergence of MAP kinase pathways on the ternary complex factor Sap-1a

1997 • 226 citations

Downstream Signalling Events Regulated by Phosphatidylinositol 3-Kinase Activity

1998 • 196 citations

Phosphorylation of Raf-1 Serine 338-Serine 339 Is an Essential Regulatory Event for Ras-Dependent Activation and Biological Signaling

1997 • 196 citations

A Golgi retention signal in a membrane-spanning domain of coronavirus E1 protein.

1991 • 185 citations

N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localization.

1994 • 165 citations

[29] Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf

1995 • 163 citations

The prenylation status of a novel plant calmodulin directs plasma membrane or nuclear localization of the protein

1999 • 162 citations

Activation of the Cellular Proto-Oncogene Product p21Ras by Addition of a Myristylation Signal

1989 • 158 citations

The Effect of Posttranslational Modifications on the Interaction of Ras2 with Adenylyl Cyclase

1993 • 139 citations

14-3-3 Facilitates Ras-Dependent Raf-1 Activation In Vitro and In Vivo

1998 • 138 citations

Inhibition of ras prenylation: A novel approach to cancer chemotherapy

1997 • 137 citations

Lipid biochemistry: functions of glycerolipids and sphingolipids in cellular signaling

1997 • 136 citations

Protein prenylation: key to ras function and cancer intervention?

1992 • 134 citations

An Intact Raf Zinc Finger Is Required for Optimal Binding to Processed Ras and for Ras-Dependent Raf Activation In Situ

1997 • 120 citations

Activity of Plasma Membrane-recruited Raf-1 Is Regulated by Ras via the Raf Zinc Finger

1997 • 117 citations

Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells.

1993 • 98 citations

Prenylation of RhoB Is Required for Its Cell Transforming Function but Not Its Ability to Activate Serum Response Element-dependent Transcription

1997 • 92 citations

Mutant ras epitopes as targets for cancer vaccines.

1996 • 87 citations

The post-translational processing of ras p21 is critical for its stimulation of mitogen-activated protein kinase.

1993 • 75 citations

The post-translational modification of ras p21 is important for Raf-1 activation.

1994 • 69 citations

A Non-farnesylated Ha-Ras Protein Can Be Palmitoylated and Trigger Potent Differentiation and Transformation

1999 • 63 citations

The RafC1 Cysteine-Rich Domain Contains Multiple Distinct Regulatory Epitopes Which Control Ras-Dependent Raf Activation

1998 • 63 citations

Post-translational Modification of H-Ras Is Required for Activation of, but Not for Association with, B-Raf

1996 • 54 citations

Farnesylation of Ras is important for the interaction with phosphoinositide 3‐kinase γ

1999 • 50 citations

Transforming activity of ras proteins translocated to the plasma membrane by a myristoylation sequence from the src gene product.

1988 • 39 citations

Innovative treatment programs against cancer

1998 • 34 citations

Derivatives of activated H-ras lacking C-terminal lipid modifications retain transforming ability if targeted to the correct subcellular location

1997 • 26 citations

Transforming activity of ras proteins translocated to the plasma membrane by a myristoylation sequence from the src gene product.

1988 • 17 citations

The structure of the carboxyl terminus of the p21 protein. Structural relationship to the nucleotide-binding/transforming regions of the protein

1990 • 6 citations

The v-sis oncoprotein loses transforming activity when targeted to the early Golgi complex.

1994 • 4 citations