Farnesylation of Ras is important for the interaction with phosphoinositide 3‐kinase γ

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants

1997 • 1,482 citations

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.

1990 • 1,077 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

1989 • 881 citations

Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family

1982 • 836 citations

Linkage of G Protein-Coupled Receptors to the MAPK Signaling Pathway Through PI 3-Kinase γ

1997 • 671 citations

Benzodiazepine Peptidomimetics: Potent Inhibitors of Ras Farnesylation In Animal Cells

1993 • 631 citations

The 2.2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with RaplA and a GTP analogue

1995 • 627 citations

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation.

1995 • 609 citations

Selective Inhibition of ras -Dependent Transformation by a Farnesyltransferase Inhibitor

1993 • 578 citations

Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation.

1996 • 568 citations

Ras C-terminal processing enzymes—New drug targets?

1991 • 461 citations

The Baculovirus Expression System: A Laboratory Guide

1993 • 404 citations

Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes

1995 • 359 citations

The Baculovirus Expression System

1992 • 337 citations

Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation.

1990 • 333 citations

Bifurcation of Lipid and Protein Kinase Signals of PI3Kγ to the Protein Kinases PKB and MAPK

1998 • 310 citations

Methylation and proteolysis are essential for efficient membrane binding of prenylated p21K-ras(B).

1991 • 291 citations

Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity.

1992 • 268 citations

Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro.

1993 • 251 citations

Interaction of Ras and Raf in intact mammalian cells upon extracellular stimulation.

1994 • 221 citations

Gβγ Stimulates Phosphoinositide 3-Kinase-γ by Direct Interaction with Two Domains of the Catalytic p110 Subunit

1998 • 191 citations

Stimulation of gene induction and cell growth by the Ras effector Rlf

1997 • 167 citations

Cysteine-rich Region of Raf-1 Interacts with Activator Domain of Post-translationally Modified Ha-Ras

1995 • 157 citations

Activation of c-Raf-1 by Ras and Src through different mechanisms: activationin vivoandin vitro

1997 • 140 citations

The Effect of Posttranslational Modifications on the Interaction of Ras2 with Adenylyl Cyclase

1993 • 139 citations

An Intact Raf Zinc Finger Is Required for Optimal Binding to Processed Ras and for Ras-Dependent Raf Activation In Situ

1997 • 120 citations

In vitro processing of recombinant G protein gamma subunits. Requirements for assembly of an active beta gamma complex.

1994 • 118 citations

A novel role for RhoGDI as an inhibitor of GAP proteins.

1993 • 117 citations

Prenylation-dependent Association of Ki-Ras with Microtubules

1997 • 117 citations

Prenylation of Ras proteins is required for efficient hSOS1-promoted guanine nucleotide exchange.

1994 • 110 citations

Lipid kinase and protein kinase activities of G-protein-coupled phosphoinositide 3-kinase γ: structure–activity analysis and interactions with wortmannin

1997 • 102 citations

Interaction of Ras with phosphoinositide 3-kinase γ

1997 • 87 citations

The post-translational processing of ras p21 is critical for its stimulation of mitogen-activated protein kinase.

1993 • 75 citations

The post-translational modification of ras p21 is important for Raf-1 activation.

1994 • 69 citations

Purification, characterization, and western blot analysis of human GTPase-activating protein from native and recombinant sources.

1990 • 69 citations

The Farnesyl Group of H-Ras Facilitates the Activation of a Soluble Upstream Activator of Mitogen-activated Protein Kinase

1995 • 60 citations

Equilibrium and Kinetic Measurements Reveal Rapidly Reversible Binding of Ras to Raf

1996 • 56 citations

Post-translational Modification of H-Ras Is Required for Activation of, but Not for Association with, B-Raf

1996 • 54 citations

Expression and characterization of the Ha-ras p21 protein produced at high levels in the insect/baculovirus system

1989 • 49 citations

Evidence for a High Affinity, Saturable, Prenylation-dependent p21 Binding Site in Plasma Membranes

1998 • 44 citations

Purification and Characterization of REKS from Xenopus Eggs

1995 • 39 citations

The posttranslational processing of ras p21 is critical for its stimulation of yeast adenylate cyclase.

1992 • 37 citations

Characterization of recombinant human Kirsten-ras (4B) p21 produced at high levels in Escherichia coli and insect baculovirus expression systems

1991 • 35 citations

[7] Reticulocyte lysate assay for in Vitro translation and posttranslational modification of Ras proteins

1995 • 27 citations

A New Function of p120-GTPase-activating Protein

1997 • 15 citations

[32] Ras-Raf complexes: Analyses of complexes formed in Vivo

1995 • 15 citations