Novel β2-adrenergic receptor signaling pathways

Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling.

2001 • 1,794 citations

β-Arrestin-Dependent Formation of β ₂ Adrenergic Receptor-Src Protein Kinase Complexes

1999 • 1,427 citations

Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains

1997 • 1,371 citations

G PROTEIN–COUPLED RECEPTOR KINASES

1998 • 1,335 citations

β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor

1996 • 1,329 citations

Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A

1997 • 1,247 citations

THE ROLE OF RECEPTOR KINASES AND ARRESTINS IN G PROTEIN–COUPLED RECEPTOR REGULATION

1998 • 1,074 citations

G-protein-coupled receptors and signaling networks: emerging paradigms

2001 • 1,005 citations

Role of β-Arrestin in Mediating Agonist-Promoted G Protein-Coupled Receptor Internalization

1996 • 938 citations

Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds

2001 • 808 citations

Regulation of Receptor Fate by Ubiquitination of Activated β ₂ -Adrenergic Receptor and β-Arrestin

2001 • 807 citations

β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3

2000 • 804 citations

β-Arrestin–Dependent Endocytosis of Proteinase-Activated Receptor 2 Is Required for Intracellular Targeting of Activated Erk1/2

2000 • 799 citations

A Peptide Derived from a β2-Adrenergic Receptor Transmembrane Domain Inhibits Both Receptor Dimerization and Activation

1996 • 758 citations

Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor

1995 • 714 citations

A kinase-regulated PDZ-domain interaction controls endocytic sorting of the β2-adrenergic receptor

1999 • 673 citations

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.

1986 • 650 citations

Detection of β ₂ -adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET)

2000 • 631 citations

The β2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange

1998 • 582 citations

Dimerization: An Emerging Concept for G Protein–Coupled Receptor Ontogeny and Function

2002 • 580 citations

PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane

1999 • 469 citations

β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family

1989 • 451 citations

Switching Signals On or Off by Receptor Dimerization

1998 • 428 citations

The β2-Adrenergic Receptor Mediates Extracellular Signal-regulated Kinase Activation via Assembly of a Multi-receptor Complex with the Epidermal Growth Factor Receptor

2000 • 411 citations

The proliferative and antiapoptotic effects of substance P are facilitated by formation of a β-arrestin-dependent scaffolding complex

2000 • 392 citations

beta -Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking

2001 • 346 citations

Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger.

1995 • 344 citations

AKAP Mediated Signal Transduction

2002 • 343 citations

Targeted Disruption of the β2 Adrenergic Receptor Gene

1999 • 325 citations

Heptahelical Receptor Signaling: Beyond the G Protein Paradigm

1999 • 323 citations

Expanding roles for β-arrestins as scaffolds and adapters in GPCR signaling and trafficking

2001 • 316 citations

Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein.

1985 • 312 citations

Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET)

2000 • 304 citations

Identification of a Gs activator region of the β2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation

1991 • 273 citations

G protein-coupled receptor interacting proteins: Emerging roles in localization and signal transduction

2002 • 263 citations

Src-mediated Tyrosine Phosphorylation of Dynamin Is Required for β2-Adrenergic Receptor Internalization and Mitogen-activated Protein Kinase Signaling

1999 • 259 citations

Regulation of the TRP Ca2+ Channel by INAD in Drosophila Photoreceptors

1996 • 256 citations

Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor.

1983 • 247 citations

Identification of the G Protein-coupled Receptor Kinase Phosphorylation Sites in the Human β2-Adrenergic Receptor

1996 • 230 citations

Assembly of an A kinase-anchoring protein–β 2 -adrenergic receptor complex facilitates receptor phosphorylation and signaling

2000 • 219 citations

Role of Clathrin-mediated Endocytosis in Agonist-induced Down-regulation of the β2-Adrenergic Receptor

1998 • 211 citations

Dynamic Complexes of β2-Adrenergic Receptors with Protein Kinases and Phosphatases and the Role of Gravin

1999 • 208 citations

Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice.

1996 • 205 citations

Regulation of Membrane Targeting of the G Protein-coupled Receptor Kinase 2 by Protein Kinase A and Its Anchoring Protein AKAP79

2001 • 158 citations

Binding of the β2 Adrenergic Receptor toN-Ethylmaleimide-sensitive Factor Regulates Receptor Recycling

2001 • 137 citations

Gravin-mediated Formation of Signaling Complexes in β2-Adrenergic Receptor Desensitization and Resensitization

2000 • 121 citations

Agonist-dependent Phosphorylation of the G Protein-coupled Receptor Kinase 2 (GRK2) by Src Tyrosine Kinase

1999 • 106 citations

c-Src Tyrosine Kinase Binds the β2-Adrenergic Receptor via Phospho-Tyr-350, Phosphorylates G-protein-linked Receptor Kinase 2, and Mediates Agonist-induced Receptor Desensitization

2001 • 105 citations

Cross-talk between tyrosine kinase and G-protein-linked receptors. Phosphorylation of beta 2-adrenergic receptors in response to insulin.

1992 • 102 citations

The β-Adrenergic Receptor Is a Substrate for the Insulin Receptor Tyrosine Kinase

1996 • 98 citations

The Scaffold Protein Gravin (cAMP-dependent Protein Kinase-anchoring Protein 250) Binds the β2-Adrenergic Receptor via the Receptor Cytoplasmic Arg-329 to Leu-413 Domain and Provides a Mobile Scaffold during Desensitization

2001 • 96 citations

Insulin Stimulates Sequestration of β-Adrenergic Receptors and Enhanced Association of β-Adrenergic Receptors with Grb2 via Tyrosine 350

1998 • 87 citations

A Novel Interaction between Adrenergic Receptors and the α-Subunit of Eukaryotic Initiation Factor 2B

1997 • 74 citations

Phosphorylation of Tyrosyl Residues 350/354 of the β-Adrenergic Receptor Is Obligatory for Counterregulatory Effects of Insulin

1995 • 72 citations

Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs

1998 • 72 citations

Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase. Structural alterations in the beta-adrenergic receptor revealed by photoaffinity labeling.

1982 • 68 citations

Insulin-like Growth Factor Receptor-1 Stimulates Phosphorylation of the β2-Adrenergic Receptor in Vivo on Sites Distinct from Those Phosphorylated in Response to Insulin

1996 • 64 citations

Mutation of tyrosine-141 inhibits insulin-promoted tyrosine phosphorylation and increased responsiveness of the human beta 2-adrenergic receptor.

1995 • 59 citations

Insulin Activation of Mitogen-activated Protein Kinases Erk1,2 Is Amplified via β-adrenergic Receptor Expression and Requires the Integrity of the Tyr350 of the Receptor

2000 • 31 citations

Regulation of G Protein Coupled Receptors

1997 • 21 citations

Insulin Stimulates Phosphorylation of the β2-Adrenergic Receptor by the Insulin Receptor, Creating a Potent Feedback Inhibitor of Its Tyrosine Kinase

2002 • 20 citations