Identification of the G Protein-coupled Receptor Kinase Phosphorylation Sites in the Human β2-Adrenergic Receptor

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

1993 • 1,213 citations

Role of βγ Subunits of G Proteins in Targeting the β-Adrenergic Receptor Kinase to Membrane-Bound Receptors

1992 • 703 citations

Protein kinases that phosphorylate activated G protein‐coupled receptors

1995 • 520 citations

Structure and mechanism of the G protein-coupled receptor kinases.

1993 • 480 citations

Light-dependent phosphorylation of rhodopsin: number of phosphorylation sites

1982 • 441 citations

Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization

1988 • 429 citations

Phosphorylation Sites on Two Domains of the β2-Adrenergic Receptor Are Involved in Distinct Pathways of Receptor Desensitization

1989 • 415 citations

Pleckstrin Homology Domain-mediated Membrane Association and Activation of the β-Adrenergic Receptor Kinase Requires Coordinate Interaction with Gβγ Subunits and Lipid

1995 • 360 citations

Mechanism of rhodopsin kinase activation

1991 • 301 citations

Role of acidic amino acids in peptide substrates of the .beta.-adrenergic receptor kinase and rhodopsin kinase

1991 • 220 citations

Mammalian .beta.2-adrenergic receptor: purification and characterization

1984 • 207 citations

Sequential phosphorylation of rhodopsin at multiple sites

1993 • 204 citations

Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases.

1994 • 202 citations

The multiple membrane spanning topography of the beta 2-adrenergic receptor. Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited proteolysis.

1987 • 199 citations

Rhodopsin Phosphorylation and Dephosphorylation in Vivo

1995 • 176 citations

A small region of the beta-adrenergic receptor is selectively involved in its rapid regulation.

1991 • 166 citations

Mass spectrometric identification of phosphorylation sites in bleached bovine rhodopsin

1993 • 140 citations

G protein .beta..gamma. subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of .alpha. subunits by pertussis toxin but differential interactions with Gs.alpha.

1989 • 139 citations

Phosphorylation sites in bovine rhodopsin

1993 • 129 citations

Four Consecutive Serines in the Third Intracellular Loop Are the Sites for β-Adrenergic Receptor Kinase-mediated Phosphorylation and Desensitization of the α2A-Adrenergic Receptor

1995 • 122 citations

Pure β-adrenergic receptor: the single polypeptide confers catecholamine responsiveness to adenylate cyclase

1983 • 114 citations

Phosphorylation of the N-Formyl Peptide Receptor Carboxyl Terminus by the G Protein-coupled Receptor Kinase, GRK2

1995 • 108 citations

Control of Rhodopsin Multiple Phosphorylation

1994 • 95 citations

Isolation and identification of the phosphorylated species of rhodopsin

1984 • 81 citations

Substrate recognition determinants for rhodopsin kinase: studies with synthetic peptides, polyanions, and polycations

1989 • 80 citations

Identification of the Major Phosphorylation Sites in Human C5a Anaphylatoxin Receptor in Vivo

1995 • 68 citations

Rhodopsin Kinase Autophosphorylation

1995 • 61 citations

Rhodopsin kinase: Studies on the sequence of and the recognition motif for multiphosphorylations

1994 • 19 citations