Insulin Activation of Mitogen-activated Protein Kinases Erk1,2 Is Amplified via β-adrenergic Receptor Expression and Requires the Integrity of the Tyr350 of the Receptor

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

1997 • 2,268 citations

The insulin signaling system.

1994 • 1,733 citations

Phosphatidylinositol 3-Kinase Encoded by Yeast VPS 34 Gene Essential for Protein Sorting

1993 • 909 citations

Regulation of tyrosine kinase cascades by G-protein-coupled receptors

1999 • 688 citations

Phosphoinositide kinases

1996 • 529 citations

Peptides and Protein Phosphorylation

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Ras-dependent Mitogen-activated Protein Kinase Activation by G Protein-coupled Receptors

1997 • 454 citations

Physiological Regulation of G Protein-Linked Signaling

1999 • 449 citations

Mitogen-activated Protein Kinase Kinase Inhibition Does Not Block the Stimulation of Glucose Utilization by Insulin

1995 • 395 citations

Regulation of Phosphatidylinositol 3′-Kinase by Tyrosyl Phosphoproteins

1995 • 222 citations

Role of Clathrin-mediated Endocytosis in Agonist-induced Down-regulation of the β2-Adrenergic Receptor

1998 • 211 citations

Dynamic Complexes of β2-Adrenergic Receptors with Protein Kinases and Phosphatases and the Role of Gravin

1999 • 208 citations

Serotonin 5-HT1A Receptor-mediated Erk Activation Requires Calcium/Calmodulin-dependent Receptor Endocytosis

1999 • 157 citations

Insulin-mediated Targeting of Phosphatidylinositol 3-Kinase to GLUT4-containing Vesicles

1996 • 129 citations

Mechanism of Protein Kinase B Activation by Insulin/Insulin-Like Growth Factor-1 Revealed by Specific Inhibitors of Phosphoinositide 3-Kinase—Significance for Diabetes and Cancer

1999 • 115 citations

Cross-talk between tyrosine kinase and G-protein-linked receptors. Phosphorylation of beta 2-adrenergic receptors in response to insulin.

1992 • 102 citations

The β-Adrenergic Receptor Is a Substrate for the Insulin Receptor Tyrosine Kinase

1996 • 98 citations

Oligodeoxynucleotides antisense to mRNA encoding protein kinase A, protein kinase C, and beta-adrenergic receptor kinase reveal distinctive cell-type-specific roles in agonist-induced desensitization.

1994 • 95 citations

Insulin Stimulates Sequestration of β-Adrenergic Receptors and Enhanced Association of β-Adrenergic Receptors with Grb2 via Tyrosine 350

1998 • 87 citations

Phosphorylation of Tyrosyl Residues 350/354 of the β-Adrenergic Receptor Is Obligatory for Counterregulatory Effects of Insulin

1995 • 72 citations

c-Jun Amino-terminal Kinase Is Regulated by Gα12/Gα13 and Obligate for Differentiation of P19 Embryonal Carcinoma Cells by Retinoic Acid

1997 • 66 citations

Insulin-like Growth Factor Receptor-1 Stimulates Phosphorylation of the β2-Adrenergic Receptor in Vivo on Sites Distinct from Those Phosphorylated in Response to Insulin

1996 • 64 citations

Receptor density and cAMP accumulation: Analysis in CHO cells exhibiting stable expression of a cDNA that encodes the beta2-adrenergic receptor

1988 • 55 citations

Insulin signal transduction pathways

1994 • 44 citations

G-Protein-Linked Receptors as Tyrosine Kinase Substrates

1998 • 30 citations

Protein Kinase C Deficiency Blocks Recovery from Agonist-induced Desensitization

1996 • 30 citations

[24] Dynamic palmitoylation of G-protein-coupled receptors in eukaryotic cells

1995 • 29 citations

G-Protein-Linked Receptors as Substrates for Tyrosine Kinases: Cross-Talk in Signaling

1997 • 25 citations

Serum and Insulin Induce a Grb2-Dependent Shift in Agonist Affinity of β-Adrenergic Receptors

1998 • 20 citations