p38α Is Active in Vitro and in Vivo When Monophosphorylated at Threonine 180

The Protein Kinase Complement of the Human Genome

2002 • 7,708 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

The Conformational Plasticity of Protein Kinases

2002 • 1,691 citations

Comparative Genomics of the Eukaryotes

2000 • 1,688 citations

Active and Inactive Protein Kinases: Structural Basis for Regulation

1996 • 1,361 citations

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

1996 • 1,286 citations

Targeting the mitogen-activated protein kinase cascade to treat cancer

2004 • 1,093 citations

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

1990 • 1,087 citations

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

1994 • 1,005 citations

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

1999 • 970 citations

Protein phosphatases and the regulation of mitogen-activated protein kinase signalling

2000 • 796 citations

Activation Mechanism of the MAP Kinase ERK2 by Dual Phosphorylation

1997 • 724 citations

Essential Role of p38α MAP Kinase in Placental but Not Embryonic Cardiovascular Development

2000 • 509 citations

Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro.

1993 • 503 citations

Multiple components in an epidermal growth factor-stimulated protein kinase cascade

1991 • 502 citations

Structure and regulation of MAPK phosphatases

2004 • 441 citations

p38 Mitogen-Activated Protein Kinase Is Activated and Linked to TNF-α Signaling in Inflammatory Bowel Disease

2002 • 379 citations

A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C.

1993 • 373 citations

Three protein kinase structures define a common motif

1994 • 364 citations

Mechanistic Studies of the Dual Phosphorylation of Mitogen-activated Protein Kinase

1997 • 347 citations

Requirement for p38α in Erythropoietin Expression

2000 • 343 citations

Alternative p38 activation pathway mediated by T cell receptor–proximal tyrosine kinases

2005 • 292 citations

Signal transduction in Saccharomyces cerevisiae requires tyrosine and threonine phosphorylation of FUS3 and KSS1.

1992 • 292 citations

Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages.

1999 • 290 citations

Crystal Structure of p38 Mitogen-activated Protein Kinase

1996 • 252 citations

Differential Expression and Activation of p38 Mitogen-Activated Protein Kinase α, β, γ, and δ in Inflammatory Cell Lineages

1999 • 238 citations

Molecular determinants that mediate selective activation of p38 MAP kinase isoforms

2000 • 219 citations

The Activation State of p38 Mitogen-Activated Protein Kinase Determines the Efficiency of ATP Competition for Pyridinylimidazole Inhibitor Binding

1998 • 200 citations

Amino acid sequence of the catalytic subunit of bovine type II adenosine cyclic 3',5'-phosphate-dependent protein kinase

1983 • 185 citations

The structure of phosphorylated P38γ is monomeric and reveals a conserved activation-loop conformation

1999 • 129 citations

Malignant Transformation of Melanocytes to Melanoma by Constitutive Activation of Mitogen-activated Protein Kinase Kinase (MAPKK) Signaling

2003 • 127 citations

Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells

2007 • 109 citations

Modification of the catalytic subunit of bovine heart cAMP-dependent protein kinase with affinity labels related to peptide substrates.

1982 • 95 citations

A Bipartite Mechanism for ERK2 Recognition by Its Cognate Regulators and Substrates

2003 • 91 citations

Isolation of Hyperactive Mutants of the MAPK p38/Hog1 That Are Independent of MAPK Kinase Activation

2001 • 78 citations

Enzymatic Activity and Substrate Specificity of Mitogen-activated Protein Kinase p38α in Different Phosphorylation States

2008 • 72 citations

Active Mutants of the Human p38α Mitogen-activated Protein Kinase

2004 • 71 citations

Structures of p38α Active Mutants Reveal Conformational Changes in L16 Loop that Induce Autophosphorylation and Activation

2006 • 67 citations

Intrinsically active variants of all human p38 isoforms

2007 • 66 citations

Tyrosine-Phosphorylated Extracellular Signal–Regulated Kinase Associates with the Golgi Complex during G2/M Phase of the Cell Cycle

2001 • 66 citations

The Activity of the Extracellular Signal-regulated Kinase 2 Is Regulated by Differential Phosphorylation in the Activation Loop

2002 • 62 citations

Protein kinases

1994 • 60 citations

Combination of Two Activating Mutations in One HOG1 Gene Forms Hyperactive Enzymes That Induce Growth Arrest

2003 • 58 citations

Phosphorylation of Tyr-176 of the Yeast MAPK Hog1/p38 Is Not Vital for Hog1 Biological Activity

2003 • 48 citations

Detection of partially phosphorylated forms of ERK by monoclonal antibodies reveals spatial regulation of ERK activity by phosphatases

2000 • 47 citations

Hyperactive Variants of p38α Induce, whereas Hyperactive Variants of p38γ Suppress, Activating Protein 1-mediated Transcription

2006 • 47 citations