Transient anti-CD154-mediated immunotherapy of ongoing relapsing experimental autoimmune encephalomyelitis induces long-term inhibition of disease relapses

Epitope spreading in immune-mediated diseases: implications for immunotherapy

2002 • 865 citations

Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis.

1995 • 522 citations

CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis.

1996 • 492 citations

Prevention of Collagen-Induced Arthritis with an Antibody to gp39, the Ligand for CD40

1993 • 471 citations

Requirement for CD40 Ligand in Costimulation Induction, T Cell Activation, and Experimental Allergic Encephalomyelitis

1996 • 425 citations

Expression of monocyte chemoattractant protein-1 and other β-chemokines by resident glia and inflammatory cells in multiple sclerosis lesions

1998 • 400 citations

Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE

1995 • 326 citations

Multiple sclerosis☆Distribution of T cells, T cell subsets and Ia-positive macrophages in lesions of different ages

1983 • 309 citations

Epitope spreading

1996 • 302 citations

Primary demyelination in Theiler's virus infection. An ultrastructural study.

1975 • 273 citations

A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: a basis for peptide-specific therapy after onset of clinical disease.

1996 • 270 citations

CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice.

1997 • 244 citations

Induction of active and adoptive relapsing experimental autoimmune encephalomyelitis (EAE) using an encephalitogenic epitope of proteolipid protein

1992 • 231 citations

Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis

1999 • 219 citations

The Clinical Course of Experimental Autoimmune Encephalomyelitis and Inflammation Is Controlled by the Expression of Cd40 within the Central Nervous System

2001 • 215 citations

Pathologic Role and Temporal Appearance of Newly Emerging Autoepitopes in Relapsing Experimental Autoimmune Encephalomyelitis

2000 • 212 citations

Relapsing experimental allergic encephalomyelitis in the SJL/J mouse.

1981 • 197 citations

Diversity and plasticity of self recognition during the development of multiple sclerosis.

1997 • 164 citations

The functional significance of epitope spreading and its regulation by co‐stimulatory molecules

1998 • 162 citations

Spontaneous Regression of Primary Autoreactivity during Chronic Progression of Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

1999 • 155 citations

Inflammation in EAE: Role of chemokine/cytokine expression by resident and infiltrating cells

1996 • 120 citations

The relative contribution of the CD28 and gp39 costimulatory pathways in the clonal expansion and pathogenic acquisition of self-reactive T cells.

1996 • 104 citations

Suppression of murine thyroiditis via blockade of the CD40–CD40L interaction

1997 • 94 citations

Multiple Sclerosis and Central Nervous System Demyelination

1999 • 44 citations

Autoimmune Intervention by CD154 Blockade Prevents T Cell Retention and Effector Function in the Target Organ

2001 • 29 citations

Normal Th1 development following long-term therapeutic blockade of CD154-CD40 in experimental autoimmune encephalomyelitis

2002 • 23 citations

Active MRI lesion appearance in MS patients is preceded by fluctuations in circulating T-helper 1 and 2 cells

2001 • 23 citations

Normal Th1 development following long-term therapeutic blockade of CD154-CD40 in experimental autoimmune encephalomyelitis

2002 • 21 citations