Signalling molecules and cytokine production in T cells of multiple myeloma‐increased abnormalities with advancing stage

A clinical staging system for multiple myeloma correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival

1975 • 3,051 citations

CTLA-4-Mediated Inhibition in Regulation of T Cell Responses: Mechanisms and Manipulation in Tumor Immunotherapy

2001 • 964 citations

Alterations in Signal Transduction Molecules in T Lymphocytes from Tumor-Bearing Mice

1992 • 650 citations

Tumor-induced immune dysfunction: the macrophage connection

1998 • 433 citations

Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer

1997 • 383 citations

CTLA-4 blockade synergizes with tumor-derived granulocyte– macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma

1998 • 375 citations

Hydrogen peroxide secreted by tumor‐derived macrophages down‐modulates signal‐transducing zeta molecules and inhibits tumor‐specific T cell‐and natural killer cell‐mediated cytotoxicity

1996 • 364 citations

T Cell Activation and the Cytoskeleton

2000 • 264 citations

Acquired CD40-ligand deficiency in chronic lymphocytic leukemia

1997 • 206 citations

Ex vivo induction of cytokine mRNA expression in human blood samples

2001 • 119 citations

Natural interferon-alpha in combination with melphalan/prednisone versus melphalan/prednisone in the treatment of multiple myeloma stages II and III: a randomized study from the Myeloma Group of Central Sweden

1993 • 105 citations

Transforming growth factor β from multiple myeloma cells inhibits proliferation and IL-2 responsiveness in T lymphocytes

1999 • 104 citations

Zeta chain and CD28 are poorly expressed on T lymphocytes from chronic lymphocytic leukemia.

1996 • 99 citations

Deregulated cytokine network and defective Th1 immune response in multiple myeloma

2001 • 85 citations

Abnormal signal transduction by T cells of mice with parental tumors is not seen in mice bearing IL-2-secreting tumors.

1994 • 82 citations

The Expression of T Cell Related Costimulatory Molecules in Multiple Myeloma

1998 • 71 citations

Analysis of the expression of critical activation/interaction markers on peripheral blood T cells in B‐cell chronic lymphocytic leukaemia: evidence of immune dysregulation

2001 • 70 citations

Molecular aspects of multiple myeloma

2000 • 69 citations

A phase I trial of CD3/CD28-activated T cells (Xcellerated T cells) and interleukin-2 in patients with metastatic renal cell carcinoma.

2003 • 66 citations

Variable expression of CD3‐zeta and associated protein tyrosine kinases in lymphocytes from patients with myeloid malignancies

1998 • 64 citations

Immune dysfunction in cancer patients.

2002 • 62 citations

Intracellular T cell cytokines in patients with B cell chronic lymphocytic leukaemia (B‐CLL)

2002 • 60 citations

T cells from late tumor-bearing mice express normal levels of p56lck, p59fyn, ZAP-70, and CD3 zeta despite suppressed cytolytic activity.

1995 • 57 citations

Impaired expression of the CD3‐zeta chain in peripheral blood T cells of patients with chronic myeloid leukaemia results in an increased susceptibility to apoptosis

2000 • 53 citations

Feline Immunodeficiency Virus Infection Is Characterized by B7⁺CTLA4⁺T Cell Apoptosis

2002 • 53 citations

Analysis of blood T‐cell cytokine expression in B‐chronic lymphocytic leukaemia: evidence for increased levels of cytoplasmic IL‐4 in resting and activated CD8 T cells

1997 • 52 citations

Novel Role of Phosphatidylinositol 3-Kinase in CD28-mediated Costimulation

2001 • 51 citations

Differential Loss of T Cell Signaling Molecules in Metastatic Melanoma Patients’ T Lymphocyte Subsets Expressing Distinct TCR Variable Regions

1999 • 45 citations

Reduced IL-4 and interferon-gamma (IFN-γ) expression by CD4 T cells in patients with chronic lymphocytic leukaemia

1999 • 32 citations

Expression of Signal-Transducing Zeta Chain in Peripheral Blood T Cells and Natural Killer Cells in Patients with Hodgkin's Disease in Different Phases of the Disease

1999 • 29 citations

Restoration of expression of signal-transduction molecules in lymphocytes from patients with metastatic renal cell cancer after combination immunotherapy

1999 • 28 citations

Rapid recovery from T lymphopenia by CD28 superagonist therapy

2003 • 27 citations

Alteration of Signal-Transducing Molecules and Phenotypical Characteristics in Peripheral Blood Lymphocytes from Gastric Carcinoma Patients

1999 • 25 citations

DISTRIBUTION OF T‐CELL SIGNALLING MOLECULES IN HUMAN MYELOMA

1997 • 23 citations

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