Analysis of the expression of critical activation/interaction markers on peripheral blood T cells in B‐cell chronic lymphocytic leukaemia: evidence of immune dysregulation

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

1995 • 2,090 citations

The IL-2/IL-2 receptor system: A current overview

1993 • 778 citations

The Structure, Function, and Expression of Interleukin-2 Receptors on Normal and Malignant Lymphocytes

1986 • 460 citations

The role of CD40 in the regulation of humoral and cell-mediated immunity

1994 • 376 citations

The interleukin-2 receptor.

1991 • 354 citations

A central role of CD40 ligand in the regulation of CD4+ T-cell responses

1996 • 329 citations

The CD2-LFA-3 and LFA-1-ICAM pathways: relevance to T-cell recognition

1989 • 269 citations

Ins and outs of LFA-1

1995 • 260 citations

On the mode of action of LFA-1

1990 • 208 citations

Acquired CD40-ligand deficiency in chronic lymphocytic leukemia

1997 • 206 citations

T Cell Helper Defect in Patients with Chronic Lymphocytic Leukemia

1979 • 197 citations

Abnormal T-cell subpopulation function in CLL: excessive suppressor (T gamma) and deficient helper (T mu) activity with respect to B-cell proliferation

1981 • 168 citations

Side-effects of a monoclonal antibody, muromonab CD3/orthoclone OKT3: bibliographic review

1995 • 160 citations

CD40 and Its Ligand

1996 • 158 citations

Mechanisms of immunosuppression induced by antithymocyte globulins and OKT3.

1996 • 144 citations

The Cd40 ligand

1997 • 138 citations

T-cell subpopulations in chronic lymphocytic leukemia: abnormalities in distribtuion and in in vitro receptor maturation

1979 • 134 citations

Differential Sensitivity of CD4+ and CD8+T Lymphocytes to the Killing Efficacy of Fas (Apo-1/CD95) Ligand+ Tumor Cells in B Chronic Lymphocytic Leukemia

1998 • 107 citations

T-cell activation and subset patterns are altered in B-CLL and correlate with the stage of the disease

1989 • 104 citations

Zeta chain and CD28 are poorly expressed on T lymphocytes from chronic lymphocytic leukemia.

1996 • 99 citations

Paradoxical inhibition of T-cell function in response to CTLA-4 blockade; heterogeneity within the human T-cell population

2000 • 72 citations

Immunology. A Short Course

1988 • 69 citations

Interleukin 2 (IL 2) and interferon-gamma production by T lymphocytes from patients with B-chronic lymphocytic leukemia: evidence that normally released IL 2 is absorbed by the neoplastic B cell population

1985 • 52 citations

Analysis of blood T‐cell cytokine expression in B‐chronic lymphocytic leukaemia: evidence for increased levels of cytoplasmic IL‐4 in resting and activated CD8 T cells

1997 • 52 citations

Defective immunoregulatory T-cell function in chronic lymphocytic leukemia

1981 • 52 citations

Decreased CD45RA T cells in B-cell chronic lymphatic leukemia patients: correlation with disease stage

1991 • 46 citations

Expansion of T cells expressing low CD4 or CD8 levels in B-cell chronic lymphocytic leukemia: correlation with disease status and neoplastic phenotype

1994 • 35 citations

Defective interleukin-2 production and responsiveness by T cells in patients with chronic lymphocytic leukemia of B cell variety

1986 • 34 citations

Diminished DNA synthesis in T cells from B chronic lymphocytic leukemia after phytohemagglutinin, anti-CD3, and phorbol myristate acetate mitogenic signals.

1993 • 32 citations

Reduced IL-4 and interferon-gamma (IFN-γ) expression by CD4 T cells in patients with chronic lymphocytic leukaemia

1999 • 32 citations

The complexity of the B7-CD28/CTLA-4 costimulatory pathway

1998 • 22 citations

Modulation of chemical-induced lung and liver toxicity by all-trans-retinol in the male Sprague-Dawley rat

1995 • 19 citations

Selective in vivo deletion of alloactivated TH1 cells by OKT3 monoclonal antibody in acute rejection

1997 • 11 citations

Functional Differences of T cells in B-Chronic Lymphocytic Leukemia

1993 • 7 citations

OKT3 monitoring in the treatment of steroid-resistant acute rejection of hepatotransplant recipients

1998 • 7 citations