Feline Immunodeficiency Virus Infection Is Characterized by B7⁺CTLA4⁺T Cell Apoptosis

Biochemical Pathways of Caspase Activation During Apoptosis

1999 • 2,567 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS

1999 • 1,309 citations

CD8α+ and CD8α− Subclasses of Dendritic Cells Direct the Development of Distinct T Helper Cells In Vivo

1999 • 998 citations

Pathogenesis of human immunodeficiency virus infection

1993 • 835 citations

Vaccinia virus expression vector: coexpression of beta-galactosidase provides visual screening of recombinant virus plaques.

1985 • 789 citations

Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation.

1993 • 569 citations

B7-1 and B7-2 Have Overlapping, Critical Roles in Immunoglobulin Class Switching and Germinal Center Formation

1997 • 499 citations

CD28/B7 Costimulation: A Review

1998 • 447 citations

B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2.

1991 • 445 citations

Analysis of apoptosis in lymph nodes of HIV-infected persons. Intensity of apoptosis correlates with the general state of activation of the lymphoid tissue and not with stage of disease or viral burden.

1995 • 386 citations

CTLA-4: a negative regulator of autoimmune disease.

1996 • 382 citations

Analysis of host-virus interactions in AIDS with anti-gp120 T cell clones: Effect of HIV sequence variation and a mechanism for CD4+ cell depletion

1988 • 372 citations

Regulation of surface and intracellular expression of CTLA4 on mouse T cells.

1996 • 340 citations

Selective induction of B7/BB-1 on interferon-γ stimulated monocytes: A potential mechanism for amplification of T cell activation through the CD28 pathway

1991 • 325 citations

Is CTLA-4 a master switch for peripheral T cell tolerance?

1997 • 284 citations

T cell clonal anergy

1997 • 257 citations

Anergy and apoptosis in CD8+ T cells from HIV-infected persons.

1994 • 252 citations

In vivo lymphocyte tropism of feline immunodeficiency virus

1993 • 201 citations

Common epitope in human immunodeficiency virus (HIV) I-GP41 and HLA class II elicits immunosuppressive autoantibodies capable of contributing to immune dysfunction in HIV I infected individuals.

1990 • 197 citations

Vaccinia Virus Expression Vectors

1986 • 184 citations

Interleukin-10 promotes activation-induced cell death of SLE lymphocytes mediated by Fas ligand.

1997 • 178 citations

The role of B7 costimulation in T‐cell immunity

1999 • 174 citations

Development Of Clinical Disease In Cats Experimentally Infected With Feline Immunodeficiency Virus

1994 • 158 citations

CD28 and apoptosis

1995 • 147 citations

Blockade of the CD28 co-stimulatory pathway: a means to induce tolerance

1994 • 139 citations

Feline immunodeficiency virus predisposes cats to acute generalized toxoplasmosis.

1993 • 118 citations

Fas-independent death of activated CD4⁺T lymphocytes induced by CTLA-4 crosslinking

1998 • 112 citations

Acquisition of CD80 (B7-1) by T Cells

2001 • 108 citations

Expression of functional B7 and CTLA4 on rheumatoid synovial T cells.

1994 • 103 citations

Proviral burden and infection kinetics of feline immunodeficiency virus in lymphocyte subsets of blood and lymph node

1996 • 102 citations

Characterization of monoclonal antibodies to feline T lymphocytes and their use in the analysis of lymphocyte tissue distribution in the cat

1990 • 99 citations

A standardized gating technique for the generation of flow cytometry data for normal canine and normal feline blood lymphocytes

2000 • 98 citations

Early events in the immunopathogenesis of feline retrovirus infections

1991 • 92 citations

Direct and indirect mechanisms mediating apoptosis during HIV infection: contribution to in vivo CD4 T cell depletion

1993 • 91 citations

Analysis of CD80 and CD86 Expression on Peripheral Blood B Lymphocytes Reveals Increased Expression of CD86 in Lupus Patients

1997 • 90 citations

The B7 adhesion molecule is expressed on activated human T cells: Functional involvement in T‐T cell interactions

1993 • 85 citations

B7.2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding: implications for induction of antitumor immunity to T cell tumors.

1997 • 78 citations

Activated T cells can induce high levels of CTLA-4 expression on B cells.

1995 • 78 citations

AIDS as immune system activation. II. The panergic imnesia hypothesis.

1990 • 75 citations

Increased expression of CD80, CD86 and CD70 on T cells from HIV‐infected individuals upon activation in vitro: regulation by CD4⁺ T cells

1996 • 74 citations

Immunohistochemical Characterisation of Macrophages in Human Liver and Gastrointestinal Tract: Expression of CD4, HLA-DR, OKM1, and the Mature Macrophage Marker 25F9 in Normal and Diseased Tissue

1987 • 70 citations

Immunological abnormalities in the natural history of HIV infection: mechanisms and clinical relevance.

1992 • 63 citations

Elevated expression of cd80 (b7/bb1) and other accessory molecules on synovial fluid mononuclear cell subsets in rheumatoid arthritis

1994 • 62 citations

Enhanced expression of CTLA-4 (CD152) on CD4+ T cells in HIV infection

1999 • 59 citations

Mucosally Transmitted Feline Immunodeficiency Virus Induces a CD8⁺Antiviral Response that Correlates with Reduction of Cell‐Associated Virus

1998 • 57 citations

Antigen presentation by T cells inhibits IL-2 production and induces IL-4 release due to altered cognate signals.

1996 • 52 citations

A biochemical characterization of feline MHC products: Unusually high expression of class 11 antigens on peripheral blood lymphocytes

1986 • 51 citations

Progressive Expansion of an L‐Selectin–Negative CD8 Cell with Anti–Feline Immunodeficiency Virus (FIV) Suppressor Function in the Circulation of FIV‐Infected Cats

1999 • 51 citations

Induction of IL-2 and lymphokine activated killer cells in the cat

1987 • 43 citations

The CD8⁺Cell Phenotype Mediating Antiviral Activity in Feline Immunodeficiency Virus‐Infected Cats Is Characterized by Reduced Surface Expression of the CD8 β Chain

1998 • 43 citations

Elevated Interleukin-10-to-Interleukin-12 Ratio in Feline Immunodeficiency Virus-Infected Cats Predicts Loss of Type 1 Immunity to Toxoplasma gondii

1998 • 41 citations

Persistent upregulation of MHC Class II antigen expression on T-lymphocytes from cats experimentally infected with feline immunodeficiency virus

1992 • 39 citations

Aids as Immune System Activation

1995 • 35 citations

Recombinant Vaccinia Viruses: Design, Generation, and Isolation

1999 • 33 citations

CD80 and CD86 costimulatory molecules on circulating T cells of HIV infected individuals

1999 • 29 citations

Decreased mitogen responsiveness and elevated tumor necrosis factor production in cats shortly after feline immunodeficiency virus infection

1992 • 26 citations

The molecular biology of swinepox virus I. A characterization of the viral DNA

1991 • 24 citations

Altered Surface Antigen Expression on Peripheral Blood Mononuclear Cells in Cats Infected with Feline Immunodeficiency Virus.

1992 • 24 citations

Failure of correlation between B7 expression and activation of interleukin‐2‐secreting T cells

1994 • 21 citations

Spontaneous programmed cell death (PCD) process of lymphocytes of FIV-infected cats: Cellular targets and modulation

1997 • 16 citations

Apoptotic fraction in lymphoid tissue of FIV-infected SPF cats

1998 • 14 citations

Development of a CD28 Receptor Binding-Based Screen and Identification of a Biologically Active Inhibitor

1998 • 13 citations

Small Animal Model of AIDS and the Feline Immunodeficiency Virus

1993 • 9 citations

Molecular cloning and expression of feline CD28 and CTLA-4 cDNA

2000 • 6 citations

Sequence analyses of feline B7 costimulatory molecules

2000 • 5 citations