Membrane proteases: roles in tissue remodeling and tumour invasion

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

Cell biology of extracellular matrix

1992 • 1,042 citations

92-kD type IV collagenase mediates invasion of human cytotrophoblasts.

1991 • 722 citations

Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinases.

1992 • 429 citations

Degradation of extracellular-matrix proteins by human cathepsin B from normal and tumour tissues

1992 • 417 citations

Complete structure of the human gene for 92-kDa type IV collagenase. Divergent regulation of expression for the 92- and 72-kilodalton enzyme genes in HT-1080 cells.

1991 • 343 citations

Localization of messenger RNA for Mr 72,000 and 92,000 type IV collagenases in human skin cancers by in situ hybridization.

1992 • 331 citations

Tumor Cell Invasion Inhibited by TIMP-2

1991 • 324 citations

The N-terminal domain of tissue inhibitor of metalloproteinases retains metalloproteinase inhibitory activity

1991 • 324 citations

The role of the C-terminal domain in collagenase and stromelysin specificity.

1992 • 311 citations

Differential glycosylation and cell surface expression of lysosomal membrane glycoproteins in sublines of a human colon cancer exhibiting distinct metastatic potentials.

1992 • 308 citations

Directed Plasminogen Activation at the Surface of Normal and Malignant Cells

1991 • 291 citations

Degradation of collagen in the bone‐resorbing compartment underlying the osteoclast involves both cysteine‐proteinases and matrix metalloproteinases

1992 • 286 citations

TIMP-2 reduces proteolytic opening of blood-brain barrier by type IV collagenase

1992 • 282 citations

Increased expression of the Mr 72,000 type IV collagenase in human colonic adenocarcinoma.

1991 • 282 citations

The C-terminal domain of 72 kDa gelatinase A is not required for catalysis, but is essential for membrane activation and modulates interactions with tissue inhibitors of metalloproteinases

1992 • 268 citations

Extracellular Matrix Degradation

1991 • 262 citations

Differential roles for two gelatinolytic enzymes of the matrix metalloproteinase family in the remodelling cornea

1991 • 257 citations

Expression of genes encoding type IV collagen-degrading metalloproteinases and tissue inhibitors of metalloproteinases in various human tumor cells.

1992 • 228 citations

Preferential inhibition of 72- and 92-kDa gelatinases by tissue inhibitor of metalloproteinases-2

1991 • 227 citations

Metalloproteinases mediate extracellular matrix degradation by cells from mouse blastocyst outgrowths

1992 • 221 citations

In vivo paracrine interaction between urokinase and its receptor: effect on tumor cell invasion.

1991 • 216 citations

Tissue inhibitor of metalloproteinases-2 inhibits the activation of 72 kDa progelatinase by fibroblast membranes

1991 • 201 citations

Regulation of the autoactivation of human 72-kDa progelatinase by tissue inhibitor of metalloproteinases-2

1991 • 198 citations

Molecular cloning of murine 72-kDa type IV collagenase and its expression during mouse development.

1992 • 189 citations

Internalization of the urokinase-plasminogen activator inhibitor type-1 complex is mediated by the urokinase receptor.

1992 • 184 citations

Expression of transformation-associated protease(s) that degrade fibronectin at cell contact sites.

1984 • 184 citations

Proteinases of the mammary gland: developmental regulation in vivo and vectorial secretion in culture

1991 • 181 citations

Neutral proteinases of human mononuclear phagocytes. Cellular differentiation markedly alters cell phenotype for serine proteinases, metalloproteinases, and tissue inhibitor of metalloproteinases.

1991 • 179 citations

Localization of urokinase-type plasminogen activator in stromal cells in adenocarcinomas of the colon in humans.

1991 • 179 citations

Identification of an amino acid sequence from the laminin A chain that stimulates metastasis and collagenase IV production.

1990 • 178 citations

Regulation of Proteolysis at the Neutrophil-Substrate Interface by Secretory Leukoprotease Inhibitor

1990 • 168 citations

CD10 (CALLA)/neutral endopeptidase 24.11 modulates inflammatory peptide- induced changes in neutrophil morphology, migration, and adhesion proteins and is itself regulated by neutrophil activation

1991 • 165 citations

Metastatic behavior of human melanoma cell lines in nude mice correlates with urokinase-type plasminogen activator, its type-1 inhibitor, and urokinase-mediated matrix degradation.

1991 • 156 citations

Inhibition of autoproteolytic activation of interstitial procollagenase by recombinant metalloproteinase inhibitor MI/TIMP-2

1991 • 156 citations

Local degradation of fibronectin at sites of expression of the transforming gene product pp60src

1985 • 151 citations

The role of cathepsin L in malignant transformation.

1990 • 150 citations

Alanine scanning mutagenesis and functional analysis of the fibronectin-like collagen-binding domain from human 92-kDa type IV collagenase.

1992 • 146 citations

Clear zone in osteoclast function: role of podosomes in regulation of bone-resorbing activity

1991 • 142 citations

Binding of tissue inhibitor of metalloproteinases 2 to two distinct sites on human 72-kDa gelatinase. Identification of a stabilization site.

1991 • 138 citations

Inhibition of tumor invasion of smooth muscle cell layers by recombinant human metalloproteinase inhibitor.

1991 • 135 citations

Fibronectin-degrading proteases from the membranes of transformed cells

1987 • 134 citations

Cellular invasion into matrix beads: Localization of fa integrins and fibronectin to the invadopodia

1991 • 131 citations

Inhibition of murine melanoma experimental metastasis by recombinant desulfatohirudin, a highly specific thrombin inhibitor.

1991 • 129 citations

Collagenolytic cysteine proteinases of bone tissue. Cathepsin B, (pro)cathepsin L and a cathepsin L-like 70 kDa proteinase

1991 • 127 citations

A 170-kDa membrane-bound protease is associated with the expression of invasiveness by human malignant melanoma cells.

1990 • 125 citations

Role of the urokinase receptor in facilitating extracellular matrix invasion by cultured colon cancer.

1991 • 123 citations

The matrix metalloprotease matrilysin (PUMP) is expressed in developing human mononuclear phagocytes.

1992 • 121 citations

Hepsin, a cell membrane-associated protease. Characterization, tissue distribution, and gene localization.

1991 • 112 citations

Single chain urokinase. Augmentation of enzymatic activity upon binding to monocytes

1991 • 110 citations

A metalloproteinase inhibitor as an inhibitor of neovascularization

1991 • 106 citations

Localization of paxillin, a focal adhesion protein, to smooth muscle dense plaques, and the myotendinous and neuromuscular junctions of skeletal muscle

1991 • 100 citations

Binding of latent and high M r active forms of stromelysin to collagen is mediated by the C-terminal domain

1991 • 95 citations

Proteolytic processing and glycosylation of cathepsin B. The role of the primary structure of the latent precursor and of the carbohydrate moiety for cell-type-specific molecular forms of the enzyme

1992 • 94 citations

Metalloproteinases and tissue damage.

1991 • 93 citations

Characterization of recombinant rat cathepsin B and nonglycosylated mutants expressed in yeast. New insights into the pH dependence of cathepsin B-catalyzed hydrolyses.

1992 • 89 citations

Inhibition of Ovulation in the Perfused Rat Ovary by the Synthetic Collagenase Inhibitor SC 444631

1991 • 87 citations

Inhibition of tumor cell invasion by a highly conserved peptide sequence from the matrix metalloproteinase enzyme prosegment.

1992 • 86 citations

The alpha subunit of meprin A. Molecular cloning and sequencing, differential expression in inbred mouse strains, and evidence for divergent evolution of the alpha and beta subunits.

1992 • 84 citations

Abrogation of the invasion of human bladder tumor cells by using protease inhibitor(s)

1992 • 77 citations

Isolation and characterization of a 70-kDa metalloprotease (gelatinase) that is elevated in Rous sarcoma virus-transformed chicken embryo fibroblasts.

1991 • 76 citations

Molecular cloning of cDNA for rat cathepsin C. Cathepsin C, a cysteine proteinase with an extremely long propeptide.

1991 • 72 citations

Meprin-A and -B. Cell surface endopeptidases of the mouse kidney.

1991 • 65 citations

Immunological quantitation of levels of tissue inhibitor of metalloproteinase-1 in human colon cancer.

1991 • 61 citations

Enrichment of collagen and gelatin degrading activities in the plasma membranes of human cancer cells.

1987 • 60 citations

Biology and Function of Tumor-Associated Trypsin Inhibitor, Tati

1991 • 53 citations

Domain structure and interactions of recombinant urokinase-type plasminogen activator.

1992 • 53 citations

Modulation of plasminogen activation and type IV collagenase activity by a synthetic peptide derived from the laminin A chain

1991 • 47 citations

Identification of a basal promoter for the human Mr 72,000 type IV collagenase gene and enhanced expression in a highly metastatic cell line.

1991 • 38 citations

Proteinases in rheumatoid arthritis.

1992 • 36 citations

Localization of collagenase at the basal plasma membrane of a human pancreatic carcinoma cell line.

1990 • 34 citations

A growth-regulated protease activity that is inhibited by the anticarcinogenic Bowman-Birk protease inhibitor.

1992 • 34 citations

In vivo and in vitro interaction of high and low molecular weight single-chain urokinase-type plasminogen activator with rat liver cells.

1992 • 28 citations

The application of a novel biotinylated affinity label for the detection of a cathepsin B-like precursor produced by breast-tumour cells in culture

1992 • 26 citations

Conformational similarities between one-chain and two-chain tissue plasminogen activator (t-PA): implications to the activation mechanism on one-chain t-PA

1992 • 24 citations

Transformation-dependent activation of urokinase-type plasminogen activator by a plasmin-independent mechanism: involvement of cell surface membranes.

1991 • 24 citations

Enzymatic properties of the phosphorylated urokinase-type plasminogen activator isolated from a human carcinomatous cell line

1992 • 21 citations

A highly sensitive e.l.i.s.a. for endopeptidase-24.11, the common acute-lymphoblastic-leukaemia antigen (CALLA, CD-10), applicable to material of porcine and human origin

1991 • 19 citations

Phosphorylation of a surface receptor bound urokinase-type plasminogen activator in a human metastatic carcinomatous cell line

1992 • 15 citations

Two-color cytofluorometry and cellular properties of the urokinase receptor associated with a human metastatic carcinomatous cell line

1991 • 15 citations

Extracellular proteases in developing chick neural retina

1991 • 13 citations