Internalization of the urokinase-plasminogen activator inhibitor type-1 complex is mediated by the urokinase receptor.

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

A cellular binding site for the Mr 55,000 form of the human plasminogen activator, urokinase.

1985 • 731 citations

Antibodies to plasminogen activator inhibit human tumor metastasis

1983 • 651 citations

Autocrine activities of basic fibroblast growth factor: regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis.

1988 • 647 citations

Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis.

1990 • 624 citations

Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol

1991 • 578 citations

The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes.

1990 • 480 citations

The plasminogen system and cell surfaces: evidence for plasminogen and urokinase receptors on the same cell type.

1986 • 466 citations

Differentiation-enhanced binding of the amino-terminal fragment of human urokinase plasminogen activator to a specific receptor on U937 monocytes.

1985 • 450 citations

Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system.

1990 • 449 citations

Receptor-mediated internalization and degradation of urokinase is caused by its specific inhibitor PAI-1.

1990 • 374 citations

Autocrine saturation of pro-urokinase receptors on human A431 cells

1986 • 361 citations

Plasminogen Activation Initiated by Single-chain Urokinase-type Plasminogen Activator

1989 • 341 citations

Activation of pro-urokinase and plasminogen on human sarcoma cells: a proteolytic system with surface-bound reactants.

1989 • 329 citations

Distinct localizations of urokinase-type plasminogen activator and its type 1 inhibitor under cultured human fibroblasts and sarcoma cells

1987 • 295 citations

In vivo invasion of modified chorioallantoic membrane by tumor cells: the role of cell surface-bound urokinase.

1988 • 273 citations

Inhibition of receptor-bound urokinase by plasminogen-activator inhibitors.

1990 • 272 citations

Modulation of metastatic potential by cell surface urokinase of murine melanoma cells.

1988 • 223 citations

In vivo paracrine interaction between urokinase and its receptor: effect on tumor cell invasion.

1991 • 216 citations

Purification of urokinase by affinity chromatography

1976 • 207 citations

Cell‐induced potentiation of the plasminogen activation system is abolished by a monoclonal antibody that recognizes the NH₂‐terminal domain of the urokinase receptor

1991 • 194 citations

Binding of single-chain prourokinase to the urokinase receptor of human U937 cells.

1986 • 191 citations

Identification of a serpin-enzyme complex receptor on human hepatoma cells and human monocytes.

1990 • 190 citations

Accessibility of receptor-bound urokinase to type-1 plasminogen activator inhibitor.

1989 • 182 citations

Inhibition of urokinase-type plasminogen activator by antibodies: the effect on dissemination of a human tumor in the nude mouse.

1991 • 179 citations

Molecular Basis of Biological Degradative Processes

1978 • 163 citations

An autocrine role for urokinase in phorbol ester-mediated differentiation of myeloid cell lines.

1991 • 137 citations

Plasminogen-activator inhibitor type 1 is a potent natural inhibitor of extracellular matrix degradation by fibrosarcoma and colon carcinoma cells.

1990 • 131 citations

Endocytosis and degradation of alpha 1-antitrypsin-protease complexes is mediated by the serpin-enzyme complex (SEC) receptor.

1990 • 121 citations

Lysosomal degradation of receptor-bound urokinase-type plasminogen activator is enhanced by its inhibitors in human trophoblastic choriocarcinoma cells.

1990 • 111 citations

Single chain urokinase. Augmentation of enzymatic activity upon binding to monocytes

1991 • 110 citations

Mouse L cells expressing human prourokinase-type plasminogen activator: effects on extracellular matrix degradation and invasion.

1989 • 99 citations

Affinity purification of active plasminogen activator inhibitor-1 (PAI-1) using immobilized anhydrourokinase

1989 • 91 citations

Complementation between urokinase-producing and receptor-producing cells in extracellular matrix degradation.

1991 • 87 citations

Urokinase-dependent cell surface proteolysis and cancer.

1990 • 85 citations

The urokinase receptor and regulation of cell surface plasminogen activation

1990 • 75 citations

Prourokinase activation on the surface of human rhabdomyosarcoma cells: localization and inactivation of newly formed urokinase-type plasminogen activator by recombinant class 2 plasminogen activator inhibitor.

1990 • 58 citations

Transformation-dependent activation of urokinase-type plasminogen activator by a plasmin-independent mechanism: involvement of cell surface membranes.

1991 • 24 citations