Human keratinocytes produce but do not process pro-interleukin-1 (IL-1) beta. Different strategies of IL-1 production and processing in monocytes and keratinocytes.

Interleukin-1

1984 • 1,625 citations

There is more than one interleukin 1

1986 • 1,226 citations

Calcium-Regulated Differentiation of Normal Human Epidermal Keratinocytes in Chemically Defined Clonal Culture and Serum-Free Serial Culture

1983 • 1,088 citations

An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes.

1989 • 767 citations

Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization.

1988 • 648 citations

Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences.

1988 • 548 citations

Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2.

1984 • 529 citations

Identification of a monocyte specific pre-interleukin 1 beta convertase activity.

1989 • 501 citations

Human keratinocytes contain mRNA indistinguishable from monocyte interleukin 1 alpha and beta mRNA. Keratinocyte epidermal cell-derived thymocyte-activating factor is identical to interleukin 1.

1986 • 384 citations

Generation of biologically active interleukin-1 beta by proteolytic cleavage of the inactive precursor.

1988 • 377 citations

Interleukin 1 gene expression in cultured human keratinocytes is augmented by ultraviolet irradiation.

1987 • 352 citations

The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor.

1987 • 342 citations

Activation of interleukin‐ 1β by a co‐induced protease

1989 • 254 citations

The kinetics of interleukin 1 secretion from activated monocytes. Differences between interleukin 1 alpha and interleukin 1 beta.

1988 • 249 citations

A Pre-aspartate-specific Protease from Human Leukocytes That Cleaves Pro-interleukin-1 β

1989 • 174 citations

Expression of membrane interleukin 1 by fibroblasts transfected with murine pro-interleukin 1 alpha cDNA.

1988 • 171 citations

Latent high molecular weight complex of transforming growth factor. beta. 1

1988 • 143 citations

Interleukin 1 binds to specific receptors on human keratinocytes and induces granulocyte macrophage colony-stimulating factor mRNA and protein. A potential autocrine role for interleukin 1 in epidermis.

1988 • 137 citations

Regulation of interleukin 1 and its receptor in human keratinocytes.

1989 • 125 citations

The expression and modulation of IL-1 alpha in murine keratinocytes.

1988 • 123 citations

Localization of human mononuclear cell interleukin 1.

1987 • 116 citations

IL-1 beta is secreted by activated murine macrophages as biologically inactive precursor.

1990 • 100 citations

Human interleukin 1 beta is not secreted from hamster fibroblasts when expressed constitutively from a transfected cDNA.

1988 • 87 citations

Alternative Cleavage of the Cachectin/Tumor Necrosis Factor Propeptide Results in a Larger, Inactive Form of Secreted Protein

1989 • 75 citations

Fibroblast interleukin 1 beta: synergistic stimulation by recombinant interleukin 1 and tumor necrosis factor and posttranscriptional regulation.

1989 • 70 citations

Acylation of monocyte and glomerular mesangial cell proteins. Myristyl acylation of the interleukin 1 precursors.

1988 • 57 citations

Synergistic interactions of IL-1 and IL-6 in T cell activation. Mitogen but not antigen receptor-induced proliferation of a cloned T helper cell line is enhanced by exogenous IL-6.

1989 • 45 citations

Hematopoietic, Lymphopoietic, and Proinflammatory Cytokines Produced by Human and Murine Keratinocytes

1988 • 34 citations