Green tea constituent epigallocatechin-3-gallate selectively inhibits COX-2 without affecting COX-1 expression in human prostate carcinoma cells

CYCLOOXYGENASES 1 AND 2

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Inhibition of Carcinogenesis by Tea

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A Prospective Study of Dietary Fat and Risk of Prostate Cancer

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Green Tea Constituent Epigallocatechin-3-Gallate and Induction of Apoptosis and Cell Cycle Arrest in Human Carcinoma Cells

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Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols

1998 • 684 citations

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Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells

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Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols

2001 • 492 citations

COX‐2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX‐2 inhibitor celecoxib

2001 • 490 citations

Many actions of cyclooxygenase‐2 in cellular dynamics and in cancer

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Green tea epigallocatechin gallate shows a pronounced growth inhibitory effect on cancerous cells but not on their normal counterparts

1998 • 392 citations

Role of p53 and NF-κB in epigallocatechin-3-gallate-induced apoptosis of LNCaP cells

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COX-2: A Target for Colon Cancer Prevention

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Molecular pathway for (−)-epigallocatechin-3-gallate-induced cell cycle arrest and apoptosis of human prostate carcinoma cells

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Growth Inhibition, Cell-Cycle Dysregulation, and Induction of Apoptosis by Green Tea Constituent (-)-Epigallocatechin-3-gallate in Androgen-Sensitive and Androgen-Insensitive Human Prostate Carcinoma Cells

2000 • 290 citations

Modulation of experimental colon tumorigenesis by types and amounts of dietary fatty acids.

2001 • 281 citations

Green tea polyphenol epigallocatechin-3-gallate inhibits the IL-1β-induced activity and expression of cyclooxygenase-2 and nitric oxide synthase-2 in human chondrocytes

2002 • 271 citations

Cyclooxygenase-2 is up-regulated in proliferative inflammatory atrophy of the prostate, but not in prostate carcinoma.

2001 • 267 citations

Effects of purified green and black tea polyphenols on cyclooxygenase- and lipoxygenase-dependent metabolism of arachidonic acid in human colon mucosa and colon tumor tissues11Abbreviations: COX, cyclooxygenase; LOX, lipoxygenase; EGCG, (-)-epigallocatechin-3-gallate; EGC, (-)-epigallocatechin; ECG, (-)-epicatechin-3-gallate; EC, (-)-epicatechin; TF, theaflavin; TF3-G, theaflavin 3-gallate; TF3′-G, theaflavin 3′-gallate; TFdiG, theaflavin 3,3′-digallate; PGE2, prostaglandin E2; HETE, …

2001 • 267 citations

Arachidonic Acid Stimulates Prostate Cancer Cell Growth: Critical Role of 5-Lipoxygenase

1997 • 262 citations

Up-regulation of cyclooxygenase 2 gene expression correlates with tumor angiogenesis in human colorectal cancer

2001 • 252 citations

Cyclooxygenase-2, Player or Spectator in Cyclooxygenase-2 Inhibitor-Induced Apoptosis in Prostate Cancer Cells

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Green tea in chemoprevention of cancer

1999 • 236 citations

Prognostic significance of elevated cyclooxygenase 2 expression in patients with adenocarcinoma of the esophagus

2002 • 229 citations

Adverse renal effects of anti‐inflammatory agents: evaluation of selective and nonselective cyclooxygenase inhibitors

2003 • 222 citations

Essential role of caspases in epigallocatechin-3-gallate-mediated inhibition of nuclear factor kappaB and induction of apoptosis

2003 • 215 citations

Suppression of Prostate Carcinogenesis by Dietary Supplementation of Celecoxib in Transgenic Adenocarcinoma of the Mouse Prostate Model

2004 • 179 citations

Inhibition of Phorbol Ester–Induced COX-2 Expression by Epigallocatechin Gallate in Mouse Skin and Cultured Human Mammary Epithelial Cells

2003 • 149 citations

Peroxisome Proliferator-Activated Receptor-γ Is a Target of Nonsteroidal Anti-Inflammatory Drugs Mediating Cyclooxygenase-Independent Inhibition of Lung Cancer Cell Growth

2002 • 140 citations

Fatty acid regulates gene expression and growth of human prostate cancer PC-3 cells

2001 • 139 citations

Differential Expression of S100A2 and S100A4 During Progression of Human Prostate Adenocarcinoma

2002 • 136 citations

Cyclooxygenase‐2 promotes prostate cancer progression

2002 • 135 citations

Chemopreventive Strategies Using NSAIDs and COX-2 Inhibitors

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Differential expression of cyclooxygenase-2 and its regulation by tumor necrosis factor-alpha in normal and malignant prostate cells.

2001 • 111 citations

Green Tea Constituent (−)-Epigallocatechin-3-gallate Inhibits Topoisomerase I Activity in Human Colon Carcinoma Cells

2001 • 109 citations

Role of eicosanoids in prostate cancer progression.

2001 • 108 citations

Green tea in chemoprevention of cancer

1999 • 108 citations

Phase I trial of exisulind (sulindac sulfone, FGN-1) as a chemopreventive agent in patients with familial adenomatous polyposis.

2000 • 106 citations

Dietary fat intake and prostate cancer risk: a case-control study in Spain.

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Induction of apoptosis in human stomach cancer cells by green tea catechins.

1998 • 97 citations

Synergistic effects of (-)-epigallocatechin gallate with sulindac against colon carcinogenesis of rats treated with azoxymethane

2002 • 94 citations

In Vitro Characterization of Enzymatic Properties and Inhibition of the p53R2 Subunit of Human Ribonucleotide Reductase

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μ-Calpain Activation in β-Lapachone-Mediated Apoptosis

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Expression of Inflammatory Modulator COX-2 in Pancreatic Ductal Adenocarcinoma and Its Relationship to Pathologic and Clinical Parameters

2001 • 80 citations

Cancer therapy and prevention by green tea: role of ornithine decarboxylase

2002 • 72 citations

Suppression of Azoxymethane-Induced Preneoplastic Lesions and Inhibition of Cyclooxygenase-2 Activity in the Colonic Mucosa of Rats Drinking a Crude Green Tea Extract

2000 • 53 citations

Adverse effects of conventional non‐steroidal anti‐inflammatory drugs on the upper gastrointestinal tract

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Arthritis Drug Approved for Polyp Prevention Blazes Trail For Other Prevention Trials

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Correlation of cyclooxygenase-2 pathway and VEGF expression in head and neck squamous cell carcinoma

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Early Trials Probe COX-2 Inhibitors' Cancer-Fighting Potential

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Novel antineoplastic isochalcones inhibit the expression of cyclooxygenase 1,2 and EGF in human prostate cancer cell line LNCaP.

2001 • 4 citations