Molecular pathway for (−)-epigallocatechin-3-gallate-induced cell cycle arrest and apoptosis of human prostate carcinoma cells

Cancer Cell Cycles

1996 • 5,379 citations

Cyclin D-dependent kinases, INK4 inhibitors and cancer

2002 • 770 citations

Green Tea Constituent Epigallocatechin-3-Gallate and Induction of Apoptosis and Cell Cycle Arrest in Human Carcinoma Cells

1997 • 767 citations

The p53 Network

1998 • 731 citations

Mechanisms of cyclin-dependent kinase regulation: structures of cdks, their cyclin activators, and cip and INK4 inhibitors

1999 • 703 citations

Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols

1998 • 684 citations

p27kip1: A Multifunctional Cyclin-Dependent Kinase Inhibitor with Prognostic Significance in Human Cancers

1999 • 594 citations

Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols

2001 • 492 citations

P53, cell cycle control and apoptosis: Implications for cancer

1995 • 467 citations

Green Tea Polyphenol Epigallocatechin-3-Gallate Differentially Modulates Nuclear Factor κB in Cancer Cells versus Normal Cells

2000 • 421 citations

p21--Negative Regulator of the Cell Cycle

1996 • 396 citations

Green tea epigallocatechin gallate shows a pronounced growth inhibitory effect on cancerous cells but not on their normal counterparts

1998 • 392 citations

Cell death: Apoptosis versus necrosis (Review)

2002 • 370 citations

Cyclin D1 Is Dispensable for G₁ Control in Retinoblastoma Gene-Deficient Cells Independently of cdk4 Activity

1995 • 370 citations

Cell cycle checkpoints and their inactivation in human cancer

2000 • 365 citations

Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (-)-epigallocatechin gallate, and theaflavins.

1997 • 356 citations

Growth inhibition and regression of human prostate and breast tumors in athymic mice by tea epigallocatechin gallate

1995 • 330 citations

‘Angioprevention’: angiogenesis is a common and key target for cancer chemopreventive agents

2002 • 330 citations

Induction of apoptosis in prostate cancer cell lines by the green tea component, (−)-epigallocatechin-3-gallate

1998 • 296 citations

Growth Inhibition, Cell-Cycle Dysregulation, and Induction of Apoptosis by Green Tea Constituent (-)-Epigallocatechin-3-gallate in Androgen-Sensitive and Androgen-Insensitive Human Prostate Carcinoma Cells

2000 • 290 citations

Apoptosis: target of cancer therapy.

2002 • 258 citations

p53 Signaling and Cell Cycle Checkpoints

2001 • 196 citations

Target to apoptosis: A hopeful weapon for prostate cancer

1997 • 191 citations

Cell cycle control as a basis for cancer drug development (Review).

2000 • 168 citations

Mechanisms of inhibition of the Ras‐MAP kinase signaling pathway in 30.7b Ras 12 cells by tea polyphenols (‐)‐epigallocatechin‐3‐gallate and theaflavin‐3,3′‐digallate ¹

2001 • 162 citations

Cell Cycle Regulation in the G1 Phase: A Promising Target for the Development of New Chemotherapeutic Anticancer Agents

2001 • 156 citations

Green Tea and Its Catechins Inhibit Breast Cancer Xenografts

2001 • 126 citations

Green Tea Constituent (−)-Epigallocatechin-3-gallate Inhibits Topoisomerase I Activity in Human Colon Carcinoma Cells

2001 • 109 citations

Chemopreventive Effects of Tea Extracts and Various Components on Human Pancreatic and Prostate Tumor Cells In Vitro

1999 • 102 citations

Induction of apoptosis in human stomach cancer cells by green tea catechins.

1998 • 97 citations

Deregulation of the cell cycle in cancer.

2000 • 94 citations

Role of p27 in prostate carcinogenesis.

1998 • 84 citations

Aberrations of the G1- and G1/S-regulating genes in human cancer

1997 • 83 citations

(-)-Epigallocatechin gallate can prevent cisplatin-induced lung tumorigenesis in A/J mice

2000 • 76 citations

Connecting signaling and cell cycle progression in growth factor-stimulated cells

2000 • 75 citations

Growth inhibition of leukemic cells by (−)-epigallocatechin gallate, the main constituent of green tea

1998 • 71 citations

Protection against induction of mouse skin papillomas with low and high risk of conversion to malignancy by green tea polyphenols

1997 • 70 citations

Effects of green tea catechins on the progression or late promotion stage of mammary gland carcinogenesis in female Sprague-Dawley rats pretreated with 7,12-dimethylbenz(a)anthracene

1997 • 65 citations

Green tea regulates cell cycle progression in oral leukoplakia

1998 • 59 citations

The role of p53 in human cancer.

2001 • 54 citations

Effect of Tea Extracts, Polyphenols, and Epigallocatechin Gallate on Azoxymethane-induced Colon Cancer

1998 • 49 citations

Cell cycle-regulated transcription in mammalian cells

1995 • 32 citations

Inhibitory Effect of Green and Black Tea on Tumor Growth

1999 • 31 citations

PATHWAYS OF APOPTOSIS AND THE MODULATION OF CELL DEATH IN CANCER

2001 • 24 citations