Cancer therapy and prevention by green tea: role of ornithine decarboxylase

Recent advances in the biochemistry of polyamines in eukaryotes

1986 • 1,587 citations

Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy.

1988 • 1,533 citations

The chemistry of tea flavonoids

1997 • 1,109 citations

Cancers of the prostate and breast among Japanese and white immigrants in Los Angeles County

1991 • 914 citations

Tea polyphenols: prevention of cancer and optimizing health

2000 • 893 citations

Green Tea Constituent Epigallocatechin-3-Gallate and Induction of Apoptosis and Cell Cycle Arrest in Human Carcinoma Cells

1997 • 767 citations

The ornithine decarboxylase gene is a transcriptional target of c-Myc.

1993 • 759 citations

Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols

1998 • 684 citations

Ornithine decarboxylase activity is critical for cell transformation

1992 • 630 citations

Polyamines as Targets for Therapeutic Intervention

1995 • 556 citations

Wide distribution of [3H](-)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue

1998 • 520 citations

Green Tea Polyphenol Epigallocatechin-3-Gallate Differentially Modulates Nuclear Factor κB in Cancer Cells versus Normal Cells

2000 • 421 citations

Green tea epigallocatechin gallate shows a pronounced growth inhibitory effect on cancerous cells but not on their normal counterparts

1998 • 392 citations

Polyamine Metabolism: A Potential Therapeutic Target in Trypanosomes

1980 • 379 citations

Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (-)-epigallocatechin gallate, and theaflavins.

1997 • 356 citations

THE INDUCTION OF ORNITHINE DECARBOXYLASE AS AN EARLY, POSSIBLY OBLIGATORY EVENT IN MOUSE SKIN CARCINOGENESIS

1976 • 353 citations

Development of difluoromethylornithine (DFMO) as a chemoprevention agent.

1999 • 328 citations

Influence of Drinking Green Tea on Breast Cancer Malignancy among Japanese Patients

1998 • 308 citations

Induction of apoptosis in prostate cancer cell lines by the green tea component, (−)-epigallocatechin-3-gallate

1998 • 296 citations

Inhibitory effect of six green tea catechins and caffeine on the growth of four selected human tumor cell lines

1996 • 269 citations

Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: structure-activity relationship and mechanisms involved.

1999 • 264 citations

Ornithine Decarboxylase: A Key Regulatory Enzyme in Normal and Neoplastic Growth

1985 • 243 citations

Transformation of NIH/3T3 cells by ornithine decarboxylase overexpression.

1993 • 220 citations

Inhibition of cyclin-dependent kinases 2 and 4 activities as well as induction of cdk inhibitors p21 and p27 during growth arrest of human breast carcinoma cells by (?)-epigallocatechin-3-gallate

1999 • 220 citations

Green tea and cancer chemoprevention

1999 • 203 citations

Overproduction of ornithine decarboxylase caused by relief of translational repression is associated with neoplastic transformation.

1994 • 202 citations

Cancer inhibition by green tea

1998 • 194 citations

Green-tea consumption and risk of stomach cancer: a population-based case-control study in Shanghai, China

1995 • 186 citations

Comparative chemopreventive mechanisms of green tea, black tea and selected polyphenol extracts measured by in vitro bioassays

2000 • 185 citations

Tea and health: a historical perspective

1997 • 183 citations

Mechanisms of Growth Inhibition of Human Lung Cancer Cell Line, PC-9, by Tea Polyphenols

1997 • 180 citations

Epigallocathechin-3 Gallate Selectively Inhibits the PDGF-BB–induced Intracellular Signaling Transduction Pathway in Vascular Smooth Muscle Cells and Inhibits Transformation ofsis-transfected NIH 3T3 Fibroblasts and Human Glioblastoma Cells (A172)

1999 • 171 citations

Activation of mitogen-activated protein kinases by green tea polyphenols: potential signaling pathways in the regulation of antioxidant-responsive element-mediated phase II enzyme gene expression

1997 • 167 citations

Ornithine decarboxylase as a target for chemoprevention

1995 • 167 citations

Inhibition of N-methyl-N'-nitro-N-nitrosoguanidine-induced carcinogenesis by (-)-epigallocatechin gallate in the rat glandular stomach.

1995 • 149 citations

Suppression of extracellular signals and cell proliferation by the black tea polyphenol, theaflavin-3,3′-digallate

1999 • 145 citations

PROTECTION AGAINST ULTRAVIOLET B RADIATION‐INDUCED EFFECTS IN THE SKIN OF SKH‐1 HAIRLESS MICE BY A POLYPHENOLIC FRACTION ISOLATED FROM GREEN TEA

1993 • 143 citations

Mechanistic Aspects of Green Tea as a Cancer Preventive: Effect of Components on Human Stomach Cancer Cell Lines

1999 • 141 citations

Modulation of programmed cell death by medicinal plants.

2000 • 129 citations

Prostate cancer chemoprevention by green tea: in vitro and in vivo inhibition of testosterone-mediated induction of ornithine decarboxylase.

1999 • 127 citations

Effect of α-Difluoromethylornithine on Rectal Mucosal Levels of Polyamines in a Randomized, Double-Blinded Trial for Colon Cancer Prevention

1998 • 126 citations

Chemoprevention of prostate carcinogenesis by alpha-difluoromethylornithine in TRAMP mice.

2000 • 125 citations

Tea and cancer: a review of the epidemiological evidence.

1996 • 121 citations

Involvement of Caspase-3 in Epigallocatechin-3-gallate-Mediated Apoptosis of Human Chondrosarcoma Cells

2000 • 118 citations

Inhibitory effects and toxicity of green tea polyphenols for gastrointestinal carcinogenesis

1996 • 117 citations

Mechanistic Findings of Green Tea as Cancer Preventive for Humans

1999 • 114 citations

Green tea in chemoprevention of cancer

1999 • 108 citations

A Very Low Dose of Green Tea Polyphenols in Drinking Water Prevents N‐Methyl‐N‐nitrosourea‐induced Colon Carcinogenesis in F344 Rats

1993 • 103 citations

Chemopreventive Effects of Tea Extracts and Various Components on Human Pancreatic and Prostate Tumor Cells In Vitro

1999 • 102 citations

Inhibition of Ultraviolet B-Induced AP-1 Activation by Theaflavins From Black Tea

2000 • 102 citations

Induction of apoptosis in human stomach cancer cells by green tea catechins.

1998 • 97 citations

Inhibitory effects of tea extracts and (−)-epigallocatechin gallate on DNA synthesis and proliferation of hepatoma and erythroleukemia cells

1993 • 95 citations

Inhibitory Effects of Persimmon (Diospyros kaki) Extract and Related Polyphenol Compounds on Growth of Human Lymphoid Leukemia Cells

1997 • 91 citations

Green tea compounds inhibit tyrosine phosphorylation of PDGF β‐receptor and transformation of A172 human glioblastoma

2000 • 89 citations

Effects of overexpression of ornithine decarboxylase (ODC) on growth control and oncogene-induced cell transformation.

1991 • 89 citations

Green tea (Camellia sinensis) extract and its possible role in the prevention of cancer.

1999 • 87 citations

Randomized Phase I Chemoprevention Dose-Seeking Study of -Difluoromethylornithine

1993 • 86 citations

Inhibition of aberrant proliferation and induction of apoptosis in pre-neoplastic human mammary epithelial cells by natural phytochemicals.

1998 • 85 citations

Modulation of cancer chemotherapy by green tea.

1998 • 83 citations

Effect of (-)-epigallocatechin gallate on leukemic blast cells from patients with acute myeloblastic leukemia

1996 • 78 citations

Inhibitory Effect of Green and Black Tea on Tumor Growth

1999 • 72 citations

Growth inhibition of leukemic cells by (−)-epigallocatechin gallate, the main constituent of green tea

1998 • 71 citations

Protective effects of green tea polyphenols administered by oral intubation against chemical carcinogen-induced forestomach and pulmonary neoplasia in A/J mice

1993 • 66 citations

Role of polyamines in mediating malignant transformation and oncogene expression

1999 • 66 citations

Polyamine metabolism in normal and in virus-transformed chick embryo fibroblasts.

1975 • 60 citations

Activation of the Proto-oncogene c-myc and c-fos by c-ras: Involvement of Polyamines

1994 • 59 citations

Inhibition of phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13- acetate-caused inflammatory responses in SENCAR mouse skin by black tea polyphenols

1997 • 59 citations

Epigallocatechin suppression of proliferation of vascular smooth muscle cells: correlation with c‐jun and JNK

1998 • 56 citations

Inhibition of oncogene expression by green tea and (‐)‐epigallocatechin gallate in mice

1995 • 55 citations

Direct Transcriptional Stimulation of the Ornithine Decarboxylase Gene by Fos in PC12 Cells but Not In Fibroblasts

1993 • 54 citations

Highlights of the Cancer Chemoprevention Studies in China

1993 • 49 citations

POLYAMINES AND NUCLEIC ACID METABOLISM IN THE CHICK EMBRYO

1970 • 48 citations

Increased ornithine decarboxylase activity in murine sarcoma virus infected cells

1976 • 47 citations

Phase I dose de-escalation trial of alpha-difluoromethylornithine in patients with grade 3 cervical intraepithelial neoplasia.

1998 • 41 citations

p44/42 mitogen-activated protein kinase is involved in the expression of ornithine decarboxylase in leukaemia L1210 cells

1999 • 40 citations

Development of difluoromethylornithine as a chemoprevention agent for the management of colon cancer

1995 • 36 citations

Involvement of protein tyrosine phosphorylation in the effect of green tea polyphenols on Ehrlich ascites tumor cells in vitro

1998 • 36 citations

Inhibition of both stage I and stage II skin tumor promotion in SENCAR mice by a polyphenolic fraction isolated from green tea: inhibition depends on the duration of polyphenol treatment

1993 • 35 citations

Intermediate biomarkers of colon cancer: modulation of expression of ras oncogene by chemopreventive agents during azoxymethane induced colon carcinogenesis

1993 • 34 citations

Polyamines induce malignant transformation in cultured NIH 3T3 fibroblasts

1998 • 33 citations

Polyamines as biomarkers of cervical intraepithelial neoplasia

1995 • 31 citations

Cellular thiols status and cell death in the effect of green tea polyphenols in Ehrlich ascites tumor cells

1999 • 22 citations

Chemoprevention of Mammary Preneoplasia

1995 • 15 citations

Effect of chemopreventive agents on intermediate biomarkers during different stages of azoxymethane-induced colon carcinogenesis.

1992 • 13 citations

Ornithine decarboxylase-induced cellular transformation: the involvement of protein tyrosine kinase(s) and pp130

1994 • 10 citations

Apoptosis induced in glioma rat cells cultivated in the presence of a medicinal infusion of green tea.

1997 • 3 citations