Cyclooxygenase-2, Player or Spectator in Cyclooxygenase-2 Inhibitor-Induced Apoptosis in Prostate Cancer Cells

Cyclooxygenase in biology and disease

1998 • 2,483 citations

Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

1996 • 2,387 citations

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1995 • 2,308 citations

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

1997 • 1,901 citations

The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

1998 • 1,561 citations

Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells.

1998 • 1,130 citations

PPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs

1999 • 1,091 citations

Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: Insight into mechanisms and implications for cancer growth and ulcer healing

1999 • 830 citations

Overexpression of Cyclooxygenase-2 Is Sufficient to Induce Tumorigenesis in Transgenic Mice

2001 • 809 citations

Cyclooxygenase-2 Inhibitors in Tumorigenesis (Part I)

1998 • 773 citations

Host cyclooxygenase-2 modulates carcinoma growth

2000 • 693 citations

The Cyclooxygenase-2 Inhibitor Celecoxib Induces Apoptosis by Blocking Akt Activation in Human Prostate Cancer Cells Independently of Bcl-2

2000 • 670 citations

Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway

1996 • 613 citations

Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis

1998 • 593 citations

Cyclooxygenase-2 and carcinogenesis

2000 • 489 citations

NS398, a selective cyclooxygenase-2 inhibitor, induces apoptosis and down-regulates bcl-2 expression in LNCaP cells.

1998 • 439 citations

Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis.

1995 • 433 citations

Intracellular unesterified arachidonic acid signals apoptosis

2000 • 423 citations

Malignant Transformation and Antineoplastic Actions of Nonsteroidal Antiinflammatory Drugs (Nsaids) on Cyclooxygenase-Null Embryo Fibroblasts

1999 • 269 citations

Cyclooxygenase-1 and -2 isoenzymes

1999 • 215 citations

Sulfone metabolite of sulindac inhibits mammary carcinogenesis.

1997 • 211 citations

Sulindac derivatives inhibit growth and induce apoptosis in human prostate cancer cell lines

1999 • 211 citations

G1 delay in cells overexpressing prostaglandin endoperoxide synthase-2.

1996 • 173 citations

Cyclooxygenase Gene Expression in Inflammation and Angiogenesis^a

1993 • 169 citations

Overexpression of Cyclooxygenase-2 Induces Cell Cycle Arrest

1999 • 114 citations

Prostaglandin J2 and 15-deoxy-delta12,14-prostaglandin J2 induce proliferation of cyclooxygenase-depleted colorectal cancer cells.

1999 • 102 citations

Tumorigenic Transformation of Immortalized ECV Endothelial Cells by Cyclooxygenase-1 Overexpression

1997 • 101 citations

Anti-Inflammatories Inhibit Cancer Growth--But How?

2001 • 99 citations

Cyclooxygenase-2 Expression Inhibits Trophic Withdrawal Apoptosis in Nerve Growth Factor-differentiated PC12 Cells

2000 • 85 citations

Apoptosis signaling pathways mediated by cyclooxygenase-2 inhibitors in prostate cancer cells

2001 • 68 citations

Malignant Transformation and Antineoplastic Actions of Nonsteroidal Antiinflammatory Drugs (Nsaids) on Cyclooxygenase-Null Embryo Fibroblasts

1999 • 12 citations