FoxP3⁺CD25⁺CD8⁺T-Cell Induction during Primary Simian Immunodeficiency Virus Infection in Cynomolgus Macaques Correlates with Low CD4⁺T-Cell Activation and High Viral Load

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

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Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

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Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

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The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer

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PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

2006 • 2,521 citations

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

2006 • 2,516 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

CHEMOKINE RECEPTORS AS HIV-1 CORECEPTORS: Roles in Viral Entry, Tropism, and Disease

1999 • 2,174 citations

CD4+CD25high Regulatory Cells in Human Peripheral Blood

2001 • 1,882 citations

Foxp3⁺CD25⁺CD4⁺ natural regulatory T cells in dominant self‐tolerance and autoimmune disease

2006 • 1,535 citations

Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

2006 • 1,496 citations

A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells.

1981 • 1,366 citations

Modulation of tryptophan catabolism by regulatory T cells

2003 • 1,323 citations

Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection

2005 • 1,267 citations

Ex Vivo Isolation and Characterization of Cd4+Cd25+ T Cells with Regulatory Properties from Human Blood

2001 • 1,168 citations

Natural regulatory T cells in infectious disease

2005 • 1,035 citations

Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells

2005 • 948 citations

PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection

2006 • 859 citations

Induction and mechanism of action of transforming growth factor‐β‐secreting Th3 regulatory cells

2001 • 856 citations

Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production

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The Influence ofHLAGenotype on AIDS

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Biologic Features of HIV-1 That Correlate with Virulence in the Host

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Cellular immune responses to HIV

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REPLICATIVE CAPACITY OF HUMAN IMMUNODEFICIENCY VIRUS FROM PATIENTS WITH VARYING SEVERITY OF HIV INFECTION

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Development and Homeostasis of T Cell Memory in Rhesus Macaque

2002 • 475 citations

CD25+CD4+ Regulatory T Cells from the Peripheral Blood of Asymptomatic HIV-infected Individuals Regulate CD4+ and CD8+ HIV-specific T Cell Immune Responses In Vitro and Are Associated with Favorable Clinical Markers of Disease Status

2004 • 444 citations

Distinct replicative and cytopathic characteristics of human immunodeficiency virus isolates

1988 • 443 citations

Human CD25+CD4+ T Suppressor Cell Clones Produce Transforming Growth Factor β, but not Interleukin 10, and Are Distinct from Type 1 T Regulatory Cells

2002 • 440 citations

Human CD4⁺CD25⁺Regulatory T Cells Control T-Cell Responses to Human Immunodeficiency Virus and Cytomegalovirus Antigens

2004 • 436 citations

Reinvigorating exhausted HIV-specific T cells via PD-1–PD-1 ligand blockade

2006 • 396 citations

Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes

2003 • 388 citations

Human immunodeficiency virus–driven expansion of CD4+CD25+ regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients

2004 • 387 citations

Modulation of tryptophan catabolism by human leukemic cells results in the conversion of CD25− into CD25+ T regulatory cells

2006 • 377 citations

Depletion of Regulatory T Cells in HIV Infection Is Associated with Immune Activation

2005 • 365 citations

Natural History of Human Immunodeficiency Virus Type 1 Viremia after Seroconversion and Proximal to AIDS in a Large Cohort of Homosexual Men

2000 • 355 citations

TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs

2005 • 339 citations

Cutting Edge: The Prevalence of Regulatory T Cells in Lymphoid Tissue Is Correlated with Viral Load in HIV-Infected Patients

2005 • 337 citations

HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS

2006 • 327 citations

HIV Infection of Naturally Occurring and Genetically Reprogrammed Human Regulatory T-cells

2004 • 308 citations

Genetically divergent strains of simian immunodeficiency virus use CCR5 as a coreceptor for entry

1997 • 307 citations

Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS

2005 • 256 citations

Premature Induction of an Immunosuppressive Regulatory T Cell Response during Acute Simian Immunodeficiency Virus Infection

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The extent of early viral replication is a critical determinant of the natural history of simian immunodeficiency virus infection

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The influence of cytokines, chemokines and their receptors on HIV‐1 replication in monocytes and macrophages

2002 • 187 citations

Sensitive and Robust One-Tube Real-Time Reverse Transcriptase-Polymerase Chain Reaction to Quantify SIV RNA Load: Comparison of One- versus Two-Enzyme Systems

2000 • 171 citations

Nonantigen specific CD8+ T suppressor lymphocytes originate from CD8+CD28− T cells and inhibit both T-Cell proliferation and CTL function

2004 • 163 citations

Foxp3 Expressing CD4+ CD25+ and CD8+CD28− T Regulatory Cells in the Peripheral Blood of Patients with Lung Cancer and Pleural Mesothelioma

2006 • 162 citations

HIV Antigens Can Induce TGF-β1-Producing Immunoregulatory CD8+ T Cells

2002 • 126 citations

Overlap between molecular markers expressed by naturally occurring CD4+CD25+ regulatory T cells and antigen specific CD4+CD25+ and CD8+CD28− T suppressor cells

2004 • 113 citations

Autoreactive human peripheral blood CD8⁺ T cells with a regulatory phenotype and function

2005 • 93 citations

Severe Depletion of CD4⁺CD25⁺Regulatory T Cells from the Intestinal Lamina Propria but Not Peripheral Blood or Lymph Nodes during Acute Simian Immunodeficiency Virus Infection

2007 • 81 citations

FOXP3 mRNA Levels are Decreased in Peripheral Blood CD4+ Lymphocytes From HIV-Positive Patients

2005 • 80 citations

Simian Immunodeficiency Virus (SIV) Infection Influences the Level and Function of Regulatory T Cells in SIV-Infected Rhesus Macaques but Not SIV-Infected Sooty Mangabeys

2007 • 71 citations

Loss of Naïve Cells Accompanies Memory CD4 ⁺ T-Cell Depletion during Long-Term Progression to AIDS in Simian Immunodeficiency Virus-Infected Macaques

2006 • 53 citations

Kinetics of Lymphocyte Proliferation during Primary Immune Response in Macaques Infected with Pathogenic Simian Immunodeficiency Virus SIVmac251: Preliminary Report of the Effect of Early Antiviral Therapy

2003 • 51 citations

HIV-Specific IL-10-Positive CD8+ T Cells Suppress Cytolysis and IL-2 Production by CD8+ T Cells

2007 • 47 citations

HIV-Specific IL-10-Positive CD8+ T Cells Are Increased in Advanced Disease and Are Associated with Decreased HIV-Specific Cytolysis

2006 • 38 citations

Do regulatory T-cells play a role in AIDS pathogenesis?

2006 • 35 citations

Memory CD4 ⁺ T-Lymphocyte Loss and Dysfunction during Primary Simian Immunodeficiency Virus Infection

2007 • 30 citations

Changes in Soluble Factor-Mediated CD8⁺Cell-Derived Antiviral Activity in Cynomolgus Macaques Infected with Simian Immunodeficiency Virus SIVmac251: Relationship to Biological Markers of Progression

2005 • 29 citations

Variation in virological parameters and antibody responses in macaques after atraumatic vaginal exposure to a pathogenic primary isolate of SIVmac251

1998 • 26 citations

CD8+ T-Cells Suppress Antigen-Specific and Allogeneic CD4+ T-Cell Responses to Herpes Simplex Virus Type 2–Infected Human Dendritic Cells

2005 • 14 citations