Molecules and mechanisms of the graft-versus-leukaemia effect

Effectiveness of Donor Natural Killer Cell Alloreactivity in Mismatched Hematopoietic Transplants

2002 • 3,274 citations

Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes

2002 • 2,781 citations

Graft-versus-leukemia reactions after bone marrow transplantation

1990 • 2,781 citations

Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia [see comments]

1995 • 2,026 citations

Reconstitution of Cellular Immunity against Cytomegalovirus in Recipients of Allogeneic Bone Marrow by Transfer of T-Cell Clones from the Donor

1995 • 1,828 citations

Antileukemic Effect of Graft-versus-Host Disease in Human Recipients of Allogeneic-Marrow Grafts

1979 • 1,538 citations

Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation.

1997 • 1,290 citations

Frequency of Major Molecular Responses to Imatinib or Interferon Alfa plus Cytarabine in Newly Diagnosed Chronic Myeloid Leukemia

2003 • 1,253 citations

Restoration of Viral Immunity in Immunodeficient Humans by the Adoptive Transfer of T Cell Clones

1992 • 1,227 citations

Adoptive T cell therapy using antigen-specific CD8⁺T cell clones for the treatment of patients with metastatic melanoma:In vivopersistence, migration, and antitumor effect of transferred T cells

2002 • 1,187 citations

HSV-TK Gene Transfer into Donor Lymphocytes for Control of Allogeneic Graft-Versus-Leukemia

1997 • 1,180 citations

Reliable prediction of T‐cell epitopes using neural networks with novel sequence representations

2003 • 1,064 citations

Regression of Metastatic Renal-Cell Carcinoma after Nonmyeloablative Allogeneic Peripheral-Blood Stem-Cell Transplantation

2000 • 1,029 citations

The HLA System

2000 • 881 citations

Long–term restoration of immunity against Epstein–Barr virus infection by adoptive transfer of gene–modified virus–specific T lymphocytes

1996 • 852 citations

T-cell depletion of HLA-identical transplants in leukemia

1991 • 771 citations

Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia

2000 • 679 citations

Adoptive-cell-transfer therapy for the treatment of patients with cancer

2003 • 656 citations

The Chemokine Receptor CXCR-4 Is Expressed on CD34+Hematopoietic Progenitors and Leukemic Cells and Mediates Transendothelial Migration Induced by Stromal Cell-Derived Factor-1

1998 • 642 citations

Stable Mixed Hematopoietic Chimerism in DLA-Identical Littermate Dogs Given Sublethal Total Body Irradiation Before and Pharmacological Immunosuppression After Marrow Transplantation

1997 • 633 citations

Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15

2003 • 630 citations

Mismatches of Minor Histocompatibility Antigens between HLA-Identical Donors and Recipients and the Development of Graft-Versus-Host Disease after Bone Marrow Transplantation

1996 • 603 citations

T–cell mediated rejection of gene–modified HIV–specific cytotoxic T lymphocytes in HIV–infected patients

1996 • 581 citations

Graft-versus-host disease after nonmyeloablative versus conventional hematopoietic stem cell transplantation

2003 • 555 citations

Acute graft-versus-host disease does not require alloantigen expression on host epithelium

2002 • 534 citations

Understanding dendritic cell and T‐lymphocyte traffic through the analysis of chemokine receptor expression

2000 • 526 citations

Treatment of Murine Leukaemia with X Rays and Homologous Bone Marrow

1956 • 449 citations

The Minor Histocompatibility Antigen HA-1: A Diallelic Gene with a Single Amino Acid Polymorphism

1998 • 434 citations

Identification of a Graft Versus Host Disease-Associated Human Minor Histocompatibility Antigen

1995 • 429 citations

Memory CD4+ T cells do not induce graft-versus-host disease

2003 • 426 citations

Isolation of High Avidity Melanoma-Reactive CTL from Heterogeneous Populations Using Peptide-MHC Tetramers

1999 • 423 citations

The Genetic Program of Hematopoietic Stem Cells

2000 • 422 citations

Allografting with nonmyeloablative conditioning following cytoreductive autografts for the treatment of patients with multiple myeloma

2003 • 421 citations

Selective elimination of leukemic CD34+ progenitor cells by cytotoxic T lymphocytes specific for WT1

2000 • 420 citations

Hematopoiesis-restricted minor histocompatibility antigens HA-1- or HA-2-specific T cells can induce complete remissions of relapsed leukemia

2003 • 420 citations

Aberrant Overexpression of the Wilms Tumor Gene (WT1) in Human Leukemia

1997 • 375 citations

Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer

2001 • 373 citations

Nonablative allogeneic hematopoietic transplantation as adoptive immunotherapy for indolent lymphoma: low incidence of toxicity, acute graft-versus-host disease, and treatment-related mortality

2001 • 373 citations

Human H-Y: a Male-Specific Histocompatibility Antigen Derived from the SMCY Protein

1995 • 358 citations

WT1 proteins: functions in growth and differentiation

2001 • 351 citations

HLA class I-restricted lysis of leukemia cells by a CD8+ cytotoxic T-lymphocyte clone specific for WT1 peptide

2000 • 351 citations

HLA-matched unrelated donor hematopoietic cell transplantation after nonmyeloablative conditioning for patients with hematologic malignancies

2003 • 350 citations

Targeted T-cell therapy for human leukemia: cytotoxic T lymphocytes specific for a peptide derived from proteinase 3 preferentially lyse human myeloid leukemia cells

1996 • 341 citations

In vivo migration and function of transferred HIV-1-specific cytotoxic T cells

1999 • 341 citations

In situ dissection of the graft-versus-host activities of cytotoxic T cells specific for minor histocompatibility antigens

2002 • 306 citations

The HLA-A*0201-Restricted H-Y Antigen Contains a Posttranslationally Modified Cysteine That Significantly Affects T Cell Recognition

1997 • 294 citations

Tetrameric HLA class I–minor histocompatibility antigen peptide complexes demonstrate minor histocompatibility antigen-specific cytotoxic T lymphocytes in patients with graft-versus-host disease

1999 • 277 citations

Transfer of allogeneic CD62L– memory T cells without graft-versus-host disease

2003 • 259 citations

Spontaneous cytotoxic T-cell responses against survivin-derived MHC class I-restricted T-cell epitopes in situ as well as ex vivo in cancer patients.

2001 • 258 citations

Female donors contribute to a selective graft-versus-leukemia effect in male recipients of HLA-matched, related hematopoietic stem cell transplants

2003 • 249 citations

Cytotoxic T Lymphocytes Specific for a Nonpolymorphic Proteinase 3 Peptide Preferentially Inhibit Chronic Myeloid Leukemia Colony-Forming Units

1997 • 245 citations

Cytotoxic T-Lymphocyte–Defined Human Minor Histocompatibility Antigens With a Restricted Tissue Distribution

1998 • 238 citations

A Human Minor Histocompatibility Antigen Specific for B Cell Acute Lymphoblastic Leukemia

1999 • 235 citations

Redirection of antileukemic reactivity of peripheral T lymphocytes using gene transfer of minor histocompatibility antigen HA-2-specific T-cell receptor complexes expressing a conserved alpha joining region

2003 • 226 citations

Chronic myelogenous leukemia shapes host immunity by selective deletion of high-avidity leukemia-specific T cells

2003 • 219 citations

Functional leukemia-associated antigen-specific memory CD8+ T cells exist in healthy individuals and in patients with chronic myelogenous leukemia before and after stem cell transplantation

2003 • 219 citations

CD8 ⁺ minor histocompatibility antigen-specific cytotoxic T lymphocyte clones eliminate human acute myeloid leukemia stem cells

1999 • 215 citations

A Human Minor Histocompatibility Antigen Resulting from Differential Expression due to a Gene Deletion

2003 • 202 citations

Pathogenesis and Treatment of Graft-Versus-Host Disease After Bone Marrow Transplant

2003 • 201 citations

A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease

2001 • 200 citations

Harnessing graft-versus-malignancy: non-myeloablative preparative regimens for allogeneic haematopoietic transplantation, an evolving strategy for adoptive immunotherapy

2000 • 199 citations

The Immunogenicity of a New Human Minor Histocompatibility Antigen Results from Differential Antigen Processing

2001 • 188 citations

Adoptive transfer of minor histocompatibility antigen-specific T lymphocytes eradicates leukemia cells without causing graft-versus-host disease

2001 • 179 citations

The Human UTY Gene Encodes a Novel HLA-B8-Restricted H-Y Antigen

2000 • 177 citations

A PR1-human leukocyte antigen-A2 tetramer can be used to isolate low-frequency cytotoxic T lymphocytes from healthy donors that selectively lyse chronic myelogenous leukemia.

1999 • 177 citations

Transfer of Specificity for Human Immunodeficiency Virus Type 1 into Primary Human T Lymphocytes by Introduction of T-Cell Receptor Genes

2000 • 169 citations

The DBY gene codes for an HLA-DQ5–restricted human male-specific minor histocompatibility antigen involved in graft-versus-host disease

2002 • 158 citations

Alloreactive killer cells: hindrance and help for haematopoietic transplants

2003 • 155 citations

Adoptive tumor therapy with T lymphocytes enriched through an IFN-γ capture assay

2001 • 152 citations

UTY gene codes for an HLA-B60–restricted human male-specific minor histocompatibility antigen involved in stem cell graft rejection: characterization of the critical polymorphic amino acid residues for T-cell recognition

2000 • 151 citations

Cutting Edge: The HLA-A*0101-Restricted HY Minor Histocompatibility Antigen Originates fromDFFRYand Contains a Cysteinylated Cysteine Residue as Identified by a Novel Mass Spectrometric Technique

1999 • 150 citations

Identification of a Polymorphic Gene, BCL2A1, Encoding Two Novel Hematopoietic Lineage-specific Minor Histocompatibility Antigens

2003 • 148 citations

The Current Status of Hematopoietic Cell Transplantation

2003 • 146 citations

Growth inhibition of clonogenic leukemic precursor cells by minor histocompatibility antigen-specific cytotoxic T lymphocytes.

1991 • 141 citations

Interferon-α, but not the ABL-kinase inhibitor imatinib (STI571), induces expression of myeloblastin and a specific T-cell response in chronic myeloid leukemia

2002 • 140 citations

Minor histocompatibility antigens in human stem cell transplantation

2003 • 137 citations

Graft-versus-leukemia effects in T lineage and B lineage acute lymphoblastic leukemia

1998 • 133 citations

The HA-2 Minor Histocompatibility Antigen Is Derived from a Diallelic Gene Encoding a Novel Human Class I Myosin Protein

2001 • 124 citations

Identification of HLA class II-restricted H-Y-specific T-helper epitope evoking CD4+ T-helper cells in H-Y-mismatched transplantation

2003 • 124 citations

Expression of cutaneous lymphocyte-associated antigen by CD8+ T cells specific for a skin-tropic virus

2002 • 124 citations

Identification of human telomerase reverse transcriptase–derived peptides that induce HLA-A24–restricted antileukemia cytotoxic T lymphocytes

2001 • 117 citations

Epitopes on proteinase-3 recognized by antibodies from patients with Wegener's granulomatosis.

1994 • 109 citations

The minor histocompatibility antigen HA-3 arises from differential proteasome–mediated cleavage of the lymphoid blast crisis (Lbc) oncoprotein

2003 • 107 citations

Recognition of a B cell leukemia-associated minor histocompatibility antigen by CTL.

1997 • 107 citations

Immunocytochemical and flow cytometric detection of proteinase 3 (myeloblastin) in normal and leukaemic myeloid cells

1995 • 107 citations

Abnormal expression of apoptosis‐related genes in haematological malignancies: overexpression of MYC is poor prognostic sign in mantle cell lymphoma

2003 • 105 citations

Expression of cutaneous lymphocyte-associated antigen by CD8+ T cells specific for a skin-tropic virus

2002 • 104 citations

Generation of bcr-abl specific cytotoxic T-lymphocytes by using dendritic cells pulsed with bcr-abl (b3a2) peptide: its applicability for donor leukocyte transfusions in marrow grafted CML patients

1999 • 95 citations

The shared tumor-associated antigen cytochrome P450 1B1 is recognized by specific cytotoxic T cells

2003 • 87 citations

Identification of a Novel HLA-B60-Restricted T Cell Epitope of the Minor Histocompatibility Antigen HA-1 Locus

2002 • 79 citations

Induction of cytotoxic T-cell responses against the oncofetal antigen-immature laminin receptor for the treatment of hematologic malignancies

2003 • 74 citations

Interleukin 15 promotes antigen-independent in vitro expansion and long-term survival of antitumor cytotoxic T lymphocytes.

2002 • 71 citations

Pharmacologically regulated Fas-mediated death of adoptively transferred T cells in a nonhuman primate model

2003 • 61 citations

Induction of HA‐1‐specific cytotoxic T‐cell clones parallels the therapeutic effect of donor lymphocyte infusion

2002 • 61 citations

Identification of a novel WT1‐derived peptide which induces human leucocyte antigen‐A24‐restricted anti‐leukaemia cytotoxic T lymphocytes

2002 • 60 citations

Bi-directional allelic recognition of the human minor histocompatibility antigen HB-1 by cytotoxic T lymphocytes

2002 • 60 citations

Human cytotoxic T lymphocytes specific for Wilms’ tumor antigen-1 inhibit engraftment of leukemia-initiating stem cells in non-obese diabetic-severe combined immunodeficient recipients

2003 • 56 citations

Disparity for a newly identified minor histocompatibility antigen, HA‐8, correlates with acute graft‐versus‐host disease after haematopoietic stem cell transplantation from an HLA‐identical sibling

2003 • 50 citations

Efficient induction of minor histocompatibility antigen HA-1-specific cytotoxic T-cells using dendritic cells retrovirally transduced with HA-1-coding cDNA

2002 • 42 citations

Dendritic cells stimulate the expansion of PML-RAR alpha specific cytotoxic T-lymphocytes: its applicability for antileukemia immunotherapy.

1999 • 34 citations

No significant association between HA-1 incompatibility and incidence of acute graft-versus-host disease after HLA-identical sibling bone marrow transplantation in Japanese patients.

2000 • 30 citations