CD4+ and CD8+ Regulatory T Cells Generated Ex Vivo with IL-2 and TGF-β Suppress a Stimulatory Graft-versus-Host Disease with a Lupus-Like Syndrome

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

REGULATION OF IMMUNE RESPONSES BY TGF-β

1998 • 1,908 citations

CD4+CD25high Regulatory Cells in Human Peripheral Blood

2001 • 1,882 citations

Regulatory T Cells in Autoimmmunity

2000 • 1,267 citations

Manual of Clinical Laboratory Immunology

1992 • 1,243 citations

Regulatory T cells in the control of immune pathology

2001 • 1,197 citations

Donor-type CD4+CD25+ Regulatory T Cells Suppress Lethal Acute Graft-Versus-Host Disease after Allogeneic Bone Marrow Transplantation

2002 • 1,117 citations

The infusion of ex vivo activated and expanded CD4+CD25+ immune regulatory cells inhibits graft-versus-host disease lethality

2002 • 1,061 citations

CD4+CD25+ T Cells Inhibit Both the Induction and Effector Function of Autoreactive T Cells and Represent a Unique Lineage of Immunoregulatory Cells

1998 • 893 citations

"Infectious" Transplantation Tolerance

1993 • 890 citations

CD4 Regulatory T Cells Prevent Lethal Autoimmunity in IL-2Rβ-Deficient Mice

2002 • 783 citations

CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses

2002 • 766 citations

Cutting Edge: Control of CD8+ T Cell Activation by CD4+CD25+ Immunoregulatory Cells

2001 • 743 citations

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering.

1992 • 734 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 709 citations

Infectious Tolerance

2002 • 614 citations

IFN-α and IL-10 Induce the Differentiation of Human Type 1 T Regulatory Cells

2001 • 610 citations

Activation of natural killer T cells by α-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes

2001 • 605 citations

A Role for TGF-β in the Generation and Expansion of CD4+CD25+ Regulatory T Cells from Human Peripheral Blood

2001 • 540 citations

Human CD4+CD25+ Regulatory, Contact-dependent T Cells Induce Interleukin 10–producing, Contact-independent Type 1-like Regulatory T Cells

2002 • 484 citations

Generation Ex Vivo of TGF-β-Producing Regulatory T Cells from CD4+CD25− Precursors

2002 • 461 citations

Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE).

1983 • 453 citations

Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus.

1982 • 421 citations

Oral tolerance: immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cells

2001 • 392 citations

Both CD4+CD25+ and CD4+CD25− Regulatory Cells Mediate Dominant Transplantation Tolerance

2002 • 372 citations

Characterization of human CD25⁺ CD4⁺ T cells in thymus, cord and adult blood

2002 • 232 citations

IL-10 and TGF- induce alloreactive CD4+CD25- T cells to acquire regulatory cell function

2003 • 185 citations

Transforming Growth Factor β1 Inhibits Fas Ligand Expression and Subsequent Activation-induced Cell Death in T Cells via Downregulation of c-Myc

1999 • 177 citations

Role of cytotoxic T lymphocytes in the prevention of lupus-like disease occurring in a murine model of graft-vs-host disease.

1987 • 169 citations

Control of CD4 effector fate: transforming growth factor beta 1 and interleukin 2 synergize to prevent apoptosis and promote effector expansion.

1995 • 168 citations

TGF-β1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression

2000 • 158 citations

The effect of TGF-β1 on immune responses of naïve versus memory CD4+ Th1/Th2 T cells

2000 • 154 citations

Decreased production of TGF-beta by lymphocytes from patients with systemic lupus erythematosus.

1998 • 153 citations

The role of transforming growth factor beta in the generation of suppression: an interaction between CD8+ T and NK cells.

1994 • 147 citations

Decreased Production of TGF-β by Lymphocytes from Patients with Systemic Lupus Erythematosus

1998 • 128 citations

CD8+ Lymphocytes from patients with systemic lupus erythematosus sustain, rather than suppress, spontaneous polyclonal IgG production and synergize with CD4+ cells to support autoantibody synthesis

1990 • 120 citations

Requirement for Transforming Growth Factor β1 in Controlling T Cell Apoptosis

2001 • 116 citations

Differential expression of Fas and Fas ligand in acute and chronic graft-versus-host disease: up-regulation of Fas and Fas ligand requires CD8+ T cell activation and IFN-gamma production.

1998 • 106 citations

Generation of an inhibitory circuit involving CD8+ T cells, IL-2, and NK cell-derived TGF-beta: contrasting effects of anti-CD2 and anti-CD3.

1998 • 99 citations

Fas- and activation-induced apoptosis are reduced in human T cells preactivated in the presence of TGF-beta 1.

1996 • 94 citations

Differential Expression of Fas and Fas Ligand in Acute and Chronic Graft-Versus-Host Disease: Up-Regulation of Fas and Fas Ligand Requires CD8+ T Cell Activation and IFN-γ Production

1998 • 87 citations

TGF-beta 1 is a potent inducer of human effector T cells.

1994 • 85 citations

Allosuppressor and allohelper T cells in acute and chronic graft-vs-host disease. I. Alloreactive suppressor cells rather than killer T cells appear to be the decisive effector cells in lethal graft-vs.-host disease.

1982 • 67 citations

The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases.

2002 • 66 citations

Progression from Acute to Chronic Disease in a Murine Parent-into-F1 Model of Graft-Versus-Host Disease

2000 • 59 citations

CD4+CD25+ CELLS REGULATE CD8 CELL ANERGY IN NEONATAL TOLERANT MICE1,2

1999 • 55 citations