Stem Cells and Pattern Formation in the Nervous System

Neurogenesis in the adult human hippocampus

1998 • 6,181 citations

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

Generation of Neurons and Astrocytes from Isolated Cells of the Adult Mammalian Central Nervous System

1992 • 5,296 citations

Mammalian Neural Stem Cells

2000 • 4,689 citations

Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain

1999 • 3,822 citations

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

1999 • 3,805 citations

More hippocampal neurons in adult mice living in an enriched environment

1997 • 3,476 citations

Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation

1996 • 3,079 citations

Purification and Characterization of Mouse Hematopoietic Stem Cells

1988 • 2,856 citations

Running enhances neurogenesis, learning, and long-term potentiation in mice

1999 • 2,829 citations

Purified hematopoietic stem cells can differentiate into hepatocytes in vivo

2000 • 2,366 citations

Long-Distance Neuronal Migration in the Adult Mammalian Brain

1994 • 2,291 citations

Learning enhances adult neurogenesis in the hippocampal formation

1999 • 2,134 citations

Neuronal specification in the spinal cord: inductive signals and transcriptional codes

2000 • 2,051 citations

Neurons derived from radial glial cells establish radial units in neocortex

2001 • 1,932 citations

Identification of a Neural Stem Cell in the Adult Mammalian Central Nervous System

1999 • 1,872 citations

Direct isolation of human central nervous system stem cells

2000 • 1,822 citations

Vascular niche for adult hippocampal neurogenesis

2000 • 1,805 citations

Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone

1993 • 1,799 citations

Stem Cells

2000 • 1,783 citations

A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes

1992 • 1,514 citations

Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb

1969 • 1,471 citations

Turning Brain into Blood: A Hematopoietic Fate Adopted by Adult Neural Stem Cells in Vivo

1999 • 1,437 citations

Neural stem cells in the adult mammalian forebrain: A relatively quiescent subpopulation of subependymal cells

1994 • 1,400 citations

Clonal and Population Analyses Demonstrate That an EGF-Responsive Mammalian Embryonic CNS Precursor Is a Stem Cell

1996 • 1,366 citations

Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia.

1993 • 1,319 citations

Neurogenesis in the Neocortex of Adult Primates

1999 • 1,268 citations

Multipotent CNS Stem Cells Are Present in the Adult Mammalian Spinal Cord and Ventricular Neuroaxis

1996 • 1,209 citations

Induction of neurogenesis in the neocortex of adult mice

2000 • 1,201 citations

Single factors direct the differentiation of stem cells from the fetal and adult central nervous system.

1996 • 1,164 citations

Patterning the Vertebrate Neuraxis

1996 • 1,151 citations

Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage

2000 • 1,108 citations

Multiple new phenotypes induced in and 3T3 cells treated with 5-azacytidine

1979 • 1,101 citations

The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells

1989 • 1,097 citations

The Adult Rat Hippocampus Contains Primordial Neural Stem Cells

1997 • 1,080 citations

A Homeodomain Protein Code Specifies Progenitor Cell Identity and Neuronal Fate in the Ventral Neural Tube

2000 • 1,077 citations

Noggin Antagonizes BMP Signaling to Create a Niche for Adult Neurogenesis

2000 • 1,064 citations

Regulatory Mechanisms in Stem Cell Biology

1997 • 1,060 citations

Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor

1996 • 1,027 citations

Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain.

1995 • 1,014 citations

Cell replacement therapies for central nervous system disorders

2000 • 948 citations

Are New Neurons Formed in the Brains of Adult Mammals?

1962 • 930 citations

Fibroblast Growth Factor-2 Activates a Latent Neurogenic Program in Neural Stem Cells from Diverse Regions of the Adult CNS

1999 • 916 citations

Autoradiographic and histological studies of postnatal neurogenesis. I. A longitudinal investigation of the kinetics, migration and transformation of cells incoorporating tritiated thymidine in neonate rats, with special reference to postnatal neurogenesis in some brain regions

1966 • 904 citations

Oligodendrocyte Precursor Cells Reprogrammed to Become Multipotential CNS Stem Cells

2000 • 869 citations

Sonic Hedgehog–Regulated Oligodendrocyte Lineage Genes Encoding bHLH Proteins in the Mammalian Central Nervous System

2000 • 839 citations

Timing of CNS Cell Generation

2000 • 825 citations

Identification of neurogenin, a Vertebrate Neuronal Determination Gene

1996 • 821 citations

Distinct Neural Stem Cells Proliferate in Response to EGF and FGF in the Developing Mouse Telencephalon

1999 • 807 citations

Hippocampal neurogenesis in adult Old World primates

1999 • 804 citations

Isolation of a stem cell for neurons and glia from the mammalian neural crest

1992 • 796 citations

Alternative Neural Crest Cell Fates Are Instructively Promoted by TGFβ Superfamily Members

1996 • 785 citations

Neurogenin Promotes Neurogenesis and Inhibits Glial Differentiation by Independent Mechanisms

2001 • 785 citations

Engraftable human neural stem cells respond to development cues, replace neurons, and express foreign genes

1998 • 776 citations

The Biology of Hematopoietic Stem Cells

1995 • 775 citations

Stem Cells

2000 • 767 citations

Continuation of neurogenesis in the hippocampus of the adult macaque monkey

1999 • 765 citations

Cleavage orientation and the asymmetric inheritance of notchl immunoreactivity in mammalian neurogenesis

1995 • 764 citations

Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells

1994 • 749 citations

Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system

1993 • 744 citations

Prospective Identification, Isolation by Flow Cytometry, and In Vivo Self-Renewal of Multipotent Mammalian Neural Crest Stem Cells

1999 • 738 citations

neurogenin1 Is Essential for the Determination of Neuronal Precursors for Proximal Cranial Sensory Ganglia

1998 • 731 citations

Cell Cycle Dependence of Laminar Determination in Developing Neocortex

1991 • 718 citations

Radial Glial Identity Is Promoted by Notch1 Signaling in the Murine Forebrain

2000 • 716 citations

Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain

2000 • 716 citations

Transient Notch Activation Initiates an Irreversible Switch from Neurogenesis to Gliogenesis by Neural Crest Stem Cells

2000 • 715 citations

Diversity and Pattern in the Developing Spinal Cord

1996 • 714 citations

Adult Spinal Cord Stem Cells Generate Neurons after Transplantation in the Adult Dentate Gyrus

2000 • 697 citations

FGF-2-Responsive Neuronal Progenitors Reside in Proliferative and Quiescent Regions of the Adult Rodent Brain

1995 • 691 citations

Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation

2001 • 687 citations

Bone Morphogenetic Proteins Promote Astroglial Lineage Commitment by Mammalian Subventricular Zone Progenitor Cells

1996 • 681 citations

Wnt signalling required for expansion of neural crest and CNS progenitors

1997 • 669 citations

bFGF regulates the proliferative fate of unipotent (neuronal) and bipotent (neuronal/astroglial) EGF-generated CNS progenitor cells

1993 • 651 citations

Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo

1996 • 626 citations

Genetic influence on neurogenesis in the dentate gyrus of adult mice

1997 • 624 citations

A self-renewing multipotential stem cell in embryonic rat cerebral cortex

1994 • 578 citations

Environmental Determination of Autonomic Neurotransmitter Functions

1978 • 550 citations

THE SPECIFICATION OF DORSAL CELL FATES IN THE VERTEBRATE CENTRAL NERVOUS SYSTEM

1999 • 536 citations

De novo generation of neuronal cells from the adult mouse brain.

1992 • 535 citations

rax, Hes1, and notch1 Promote the Formation of Müller Glia by Postnatal Retinal Progenitor Cells

2000 • 519 citations

Glial growth factor restricts mammalian neural crest stem cells to a glial fate

1994 • 496 citations

Progression from Extrinsic to Intrinsic Signaling in Cell Fate Specification

1999 • 495 citations

Skeletal myogenic potential of human and mouse neural stem cells

2000 • 485 citations

Asymmetric Localization of a Mammalian Numb Homolog during Mouse Cortical Neurogenesis

1996 • 479 citations

Proliferation, differentiation, and long-term culture of primary hippocampal neurons.

1993 • 461 citations

FGF2 Concentration Regulates the Generation of Neurons and Glia from Multipotent Cortical Stem Cells

1997 • 455 citations

Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat schwann cell precursors

1995 • 449 citations

Stem cells in the adult mammalian central nervous system

1999 • 439 citations

Culture in Reduced Levels of Oxygen Promotes Clonogenic Sympathoadrenal Differentiation by Isolated Neural Crest Stem Cells

2000 • 406 citations

Multiple Routes to Astrocytic Differentiation in the CNS

1998 • 389 citations

Notch1 and Notch3 Instructively Restrict bFGF-Responsive Multipotent Neural Progenitor Cells to an Astroglial Fate

2001 • 387 citations

Endothelial Trophic Support of Neuronal Production and Recruitment from the Adult Mammalian Subependyma

1999 • 384 citations

Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines

2000 • 382 citations

Cloning and growth of multipotential neural precursors: Requirements for proliferation and differentiation

1993 • 381 citations

Progressive restriction in fate potential by neural progenitors during cerebral cortical development

2000 • 372 citations

Isolation of Lineage-Restricted Neuronal Precursors from Multipotent Neuroepithelial Stem Cells

1997 • 369 citations

Monoclonal antibodies identify blastemal cells derived from dedifferentiating muscle in newt limb regeneration

1984 • 353 citations

Response Diversity and the Timing of Progenitor Cell Maturation Are Regulated by Developmental Changes in EGFR Expression in the Cortex

1997 • 329 citations

Graded sonic hedgehog signaling and the specification of cell fate in the ventral neural tube.

1997 • 323 citations

Induction and Dorsoventral Patterning of the Telencephalon

2000 • 314 citations

Neurons, astrocytes, and oligodendrocytes of the rat cerebral cortex originate from separate progenitor cells: an ultrastructural analysis of clonally related cells

1993 • 311 citations

Otx2, Gbx2 and Fgf8 interact to position and maintain a mid–hindbrain organizer

2000 • 303 citations

FGF-2-Responsive Neural Stem Cell Proliferation Requires CCg, a Novel Autocrine/Paracrine Cofactor

2000 • 302 citations

Molecular and Cellular Approaches to Neural Development

1998 • 300 citations

Bone Morphogenetic Proteins Are Required In Vivo for the Generation of Sympathetic Neurons

1999 • 297 citations

Widespread Integration and Survival of Adult-Derived Neural Progenitor Cells in the Developing Optic Retina

1998 • 296 citations

Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats

1998 • 295 citations

Glial-Restricted Precursors Are Derived from Multipotent Neuroepithelial Stem Cells

1997 • 287 citations

Neuronal Differentiation of Precursors in the Neocortical Ventricular Zone Is Triggered by BMP

1998 • 277 citations

Glial cell fate specification modulated by the bHLH gene Hes5in mouse retina

2000 • 269 citations

Sonic hedgehog signaling is required during the appearance of spinal cord oligodendrocyte precursors

1999 • 266 citations

The combined action of two intercellular signaling pathways specifies three cell fates during vulval induction in C. elegans

1989 • 249 citations

Changes in retinal cell fate induced by overexpression of EGF receptor

1995 • 248 citations

Fate determination of neural crest cells by NOTCH-mediated lateral inhibition and asymmetrical cell division during gangliogenesis

2000 • 245 citations

Intrinsic programs of patterned cell lineages in isolated vertebrate CNS ventricular zone cells

1998 • 243 citations

Cloned multipotential precursors from the mouse cerebrum require FGF-2, whereas glial restricted precursors are stimulated with either FGF-2 or EGF

1995 • 238 citations

Specification of dopaminergic and serotonergic neurons in the vertebrate CNS

1999 • 227 citations

Purification and Characterization of Adult Oligodendrocyte Precursor Cells from the Rat Optic Nerve

1998 • 217 citations

Developmental Changes in Progenitor Cell Responsiveness to Bone Morphogenetic Proteins Differentially Modulate Progressive CNS Lineage Fate

2000 • 207 citations

Regulation of Neuronal Birth, Migration and Death in the Rat Dentate Gyrus

1996 • 195 citations

rough, a Drosophila homeobox gene required in photoreceptors R2 and R5 for inductive interactions in the developing eye

1988 • 189 citations

Lineage of radial glia in the chicken optic tectum

1992 • 187 citations

BMP and FGF regulate the development of EGF-responsive neural progenitor cells

2000 • 187 citations

A PDGF-Regulated Immediate Early Gene Response Initiates Neuronal Differentiation in Ventricular Zone Progenitor Cells

1997 • 185 citations

Evidence for multiple precursor cell types in the embryonic rat cerebral cortex

1995 • 182 citations

Maggot's hair and bug's eye: Role of cell interactions and intrinsic factors in cell fate specification

1995 • 180 citations

Molecular control of neural crest formation, migration and differentiation

2000 • 175 citations

Endothelin 3 induces the reversion of melanocytes to glia through a neural crest-derived glial-melanocytic progenitor

2000 • 173 citations

Postmigratory neural crest cells expressing c-RET display restricted developmental and proliferative capacities

1995 • 169 citations

Multiple restricted lineages in the embryonic rat cerebral cortex

1993 • 166 citations

Mammalian NUMB is an evolutionarily conserved signaling adapter protein that specifies cell fate

1996 • 159 citations

Discussion point Stem cells of the central nervous system

1998 • 156 citations

Induction of oligodendrocyte progenitors in the trunk neural tube by ventralizing signals: effects of notochord and floor plate grafts, and of sonic hedgehog

1996 • 141 citations

Integration of multiple instructive cues by neural crest stem cells reveals cell-intrinsic biases in relative growth factor responsiveness

1997 • 135 citations

Neural Crest Stem Cells Undergo Cell-Intrinsic Developmental Changes in Sensitivity to Instructive Differentiation Signals

2001 • 133 citations

Control of Cell Divisions in the Nervous System: Symmetry and Asymmetry

2000 • 128 citations

Generation of Tyrosine Hydroxylase-Producing Neurons from Precursors of the Embryonic and Adult Forebrain

1999 • 125 citations

Stem cell potential: Can anything make anything?

2001 • 125 citations

Lineage commitment of hemopoietic progenitor cells in developing blast cell colonies: influence of colony-stimulating factors.

1991 • 117 citations

Up a Notch

2000 • 114 citations

A New Role for Glia

1999 • 108 citations

Lineage Diversification of the Neural Crest: In Vitro Investigations

1993 • 108 citations

Identification of dividing, determined sensory neuron precursors in the mammalian neural crest

1999 • 101 citations

Postnatal mouse subventricular zone neuronal precursors can migrate and differentiate within multiple levels of the developing neuraxis

1997 • 99 citations

Isolated rat cortical progenitor cells are maintained in division in vitro by membrane-associated factors

1994 • 95 citations

Bipotent Cortical Progenitor Cells Process Conflicting Cues for Neurons and Glia in a Hierarchical Manner

1999 • 69 citations

In vivo transplantation of mammalian neural crest cells into chick hosts reveals a new autonomic sublineage restriction

1999 • 66 citations

Patterning the hindbrain

1996 • 54 citations

Embryonic Stem Cells Go Dopaminergic

2000 • 51 citations

Chasing fate and function of new neurons in adult brains

2000 • 37 citations

Young neurons for old brains?

1998 • 37 citations

Inductive signals and the assignment of cell fate in the spinal cord and hindbrain

1998 • 27 citations

Differentiation of neuron-like cells in cultured rat optic nerves: A neuron or common neuron-glia progenitor?

1989 • 26 citations