Understanding pathogenesis and treatment of HIV dementia: a role for magnetic resonance?

Hudson et al.

1977 • 2,560 citations

Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with Encephalopathy

1986 • 1,694 citations

The AIDS Dementia Complex

1988 • 1,387 citations

Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types

1993 • 997 citations

N-Acetyl-L-Aspartic acid: A literature review of a compound prominent in 1H-NMR spectroscopic studies of brain

1989 • 775 citations

Dementia in AIDS patients

1993 • 671 citations

HIV-associated neurologic disease incidence changes:

2001 • 597 citations

HIV-associated cognitive impairment before and after the advent of combination therapy

2002 • 585 citations

Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia

1998 • 568 citations

Early viral brain invasion in iatrogenic human immunodeficiency virus infection

1992 • 557 citations

Specific Expression of N‐Acetylaspartate in Neurons, Oligodendrocyte‐Type‐2 Astrocyte Progenitors, and Immature Oligodendrocytes In Vitro

1992 • 504 citations

Early penetration of the blood-brain-barrier by HIV.

1988 • 444 citations

Proton magnetic resonance spectroscopy studies on human brain Myo-inositol in hypo-osmolarity and hepatic encephalopathy

1994 • 413 citations

Cellular reservoirs of HIV-1 in the central nervous system of infected individuals

1996 • 412 citations

Acquired Immunodeficiency Syndrome

1983 • 410 citations

Inflammatory CNS demyelination: histopathologic correlation with in vivo quantitative proton MR spectroscopy.

1999 • 402 citations

HIV‐1 infection of subcortical astrocytes in the pediatric central nervous system

1994 • 402 citations

Overexpression of nef as a marker for restricted HIV‐1 infection of astrocytes in postmortem pediatric central nervous tissues

1994 • 365 citations

Transient Exposure to HIV-1 Tat Protein Results in Cytokine Production in Macrophages and Astrocytes

1999 • 351 citations

Metabolic disorders of the brain in chronic hepatic encephalopathy detected with H-1 MR spectroscopy.

1992 • 347 citations

?-Chemokines MCP-1 and RANTES are selectively increased in cerebrospinal fluid of patients with human immunodeficiency virus-associated dementia

1998 • 331 citations

Role of Mononuclear Phagocytes in the Pathogenesis of Human Immunodeficiency Virus Infection

1990 • 277 citations

Blood‐brain barrier abnormalities in acquired immunodeficiency syndrome: Immunohistochemical localization of serum proteins in postmortem brain

1992 • 275 citations

Low prevalence of neurological and neuropsychological abnormalities in otherwise healthy HIV‐1–infected individuals: Results from the multicenter AIDS cohort study

1989 • 267 citations

HIV-1 Tat Induces Monocyte Chemoattractant Protein-1-Mediated Monocyte Transmigration Across a Model of the Human Blood-Brain Barrier and Up-Regulates CCR5 Expression on Human Monocytes

1999 • 266 citations

Synergistic neurotoxicity by human immunodeficiency virus proteins Tat and gp120: Protection by memantine

2000 • 259 citations

AIDS dementia complex and HIV‐1 brain infection: Clinical‐virological correlations

1995 • 254 citations

Cerebral metabolite abnormalities correlate with clinical severity of HIV-1 cognitive motor complex

1999 • 238 citations

Neurobiological aspects of human immunodeficiency virus infection:Neurotoxic mechanisms

1998 • 231 citations

Highly active antiretroviral therapy reverses brain metabolite abnormalities in mild HIV dementia

1999 • 231 citations

The Tat Protein of HIV-1 Induces Tumor Necrosis Factor-α Production

1997 • 220 citations

Detection of the human immunodeficiency virus regulatory proteintatin CNS tissues

2000 • 214 citations

Morphology and distribution of HIV-1 gp41-positive microglia in subacute AIDS encephalitis

1990 • 212 citations

White matter abnormalities in HIV-1 infection: A diffusion tensor imaging study

2001 • 203 citations

Reduced brain N ‐acetylaspartate suggests neuronal loss in cognitively impaired human immunodeficiency virus‐seropositive individuals

1993 • 197 citations

Neuronal apoptosis induced by HIV-1 Tat protein and TNF-α: potentiation of neurotoxicity mediated by oxidative stress and implications for HIV-1 dementia

1998 • 189 citations

The proton NMR spectrum in acute EAE: The significance of the change in the Cho:Cr ratio

1993 • 187 citations

Spectroscopic imaging of stroke in humans

1992 • 182 citations

HIV-1 Tat Induces Neuronal Death via Tumor Necrosis Factor-α and Activation of Non-N-methyl-d-aspartate Receptors by a NFκB-Independent Mechanism

1998 • 177 citations

Induction of the Chemokines Interleukin-8 and IP-10 by Human Immunodeficiency Virus Type 1 Tat in Astrocytes

2000 • 170 citations

Elevated subcortical choline metabolites in cognitively and clinically asymptomatic HIV patients

1999 • 167 citations

Patterns of cerebral atrophy in HIV–1–infected individuals

1992 • 164 citations

Suppression of Inflammatory Neurotoxins by Highly Active Antiretroviral Therapy in Human Immunodeficiency Virus‐Associated Dementia

1998 • 162 citations

Increased Peroxynitrite Activity in AIDS Dementia Complex: Implications for the Neuropathogenesis of HIV-1 Infection

1999 • 158 citations

Proton spectroscopy of the brain in HIV infection: correlation with clinical, immunologic, and MR imaging findings.

1993 • 157 citations

AIDS dementia complex: evaluation with proton MR spectroscopic imaging.

1995 • 147 citations

Brain choline-containing compounds are elevated in HIV-positive patients before the onset of AIDS dementia complex

1996 • 143 citations

Neurological outcomes in late HIV infection: adverse impact of neurological impairment on survival and protective effect of antiviral therapy

1999 • 142 citations

HIV-related metabolic abnormalities in the brain: depiction with proton MR spectroscopy with short echo times.

1996 • 131 citations

Expression of HIV regulatory and structural mRNA in the central nervous system

1996 • 129 citations

HIV Dementia and the Basal Ganglia

1997 • 125 citations

Multislice proton magnetic resonance spectroscopic imaging in X‐linked adrenoleukodystrophy

1994 • 122 citations

Biochemical changes in the frontal lobe of HIV-infected individuals detected by magnetic resonance spectroscopy

1997 • 120 citations

Mechanisms of leukocyte trafficking into the CNS.

2000 • 119 citations

Pathobiology of Human Immunodeficiency Virus Dementia

1999 • 117 citations

Regional Gray and White Matter Metabolite Differences in Subjects With AD, With Subcortical Ischemic Vascular Dementia, and Elderly Controls With 1H Magnetic Resonance Spectroscopic Imaging

1996 • 96 citations

Cerebrovascular changes in the basal ganglia with HIV dementia

2000 • 90 citations

Quantitative Proton Magnetic Resonance Spectroscopy of Childhood Adrenoleukodystrophy

1998 • 90 citations

Acquired Immunodeficiency Syndrome

1988 • 89 citations

Organic osmolytes in acute hyponatremia

1993 • 88 citations

Clinical and spectroscopic improvement in HIV-associated cognitive impairment

2001 • 82 citations

Brain Proton Magnetic Resonance Spectroscopy in HIV-Related Encephalopathy: Identification of Evolving Metabolic Patterns in Relation to Dementia and Therapy

1997 • 81 citations

Chemokine receptors and virus entry in the central nervous system

1999 • 72 citations

HIV infection of choroid plexus in AIDS and asymptomatic HIV-infected patients suggests that the choroid plexus may be a reservoir of productive infection

1999 • 70 citations

N-acetylaspartate reductions measured by 1H MRSI in cognitively impaired HIV-seropositive individuals

1994 • 67 citations

Effects of Chronic Alcohol Abuse and HIV Infection on Brain Phosphorus Metabolites

1995 • 66 citations

Increased cerebral blood volume in HIV‐positive patients detected by functional MRI

1998 • 65 citations

Proton MRS and quantitative MRI assessment of the short term neurological response to antiretroviral therapy in AIDS

1997 • 62 citations

Cortical and subcortical chemical pathology in Alzheimer's disease as assessed by multislice proton magnetic resonance spectroscopic imaging

1996 • 60 citations

HIV Type 1 Infection of Human Astrocytes Is Restricted by Inefficient Viral Entry

2001 • 57 citations

Progress in Clinical Neurosciences: The Neuropathogenesis of HIV Infection: Host-Virus Interaction and the Impact of Therapy

2002 • 56 citations

A Multicenter Proton Magnetic Resonance Spectroscopy Study of Neurological Complications of AIDS

1996 • 53 citations

Review: Neuronal injury in HIV infection

1999 • 42 citations

Frequency and topographical distribution of CD68-positive macrophages and HIV-1 core proteins in HIV-associated brain lesions.

1993 • 41 citations

Cerebral Metabolic Alterations in Human Immunodeficiency Virus-Related Encephalopathy Detected by Proton Magnetic Resonance Spectroscopy

1997 • 34 citations

Serial MRI and MRS studies with unusual findings in Rasmussen’s encephalitis

2000 • 29 citations

Changes in N-acetylaspartate and myo-inositol detected in the cerebral cortex of hamsters with Creutzfeldt-Jakob disease

1998 • 22 citations

Proton MR Spectroscopy and MR Imaging in Acute and Chronic Multiple Sclerosis — Ringlike Appearances in Acute Plaques

1996 • 19 citations

Proton MR Spectroscopy and MR Imaging in Acute and Chronic Multiple Sclerosis — Ringlike Appearances in Acute Plaques

1996 • 7 citations

Molecular and Functional Magnetic Resonance Neuroimaging for the Study of Dementiaa

1996 • 6 citations