The Tat Protein of HIV-1 Induces Tumor Necrosis Factor-α Production

Basic Methods in Molecular Biology

1986 • 3,284 citations

Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation

1993 • 805 citations

Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis

1994 • 672 citations

Secretion of Neurotoxins by Mononuclear Phagocytes Infected with HIV-1

1990 • 628 citations

Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: implications for the neuropathogenesis of HIV disease.

1992 • 531 citations

Intracerebral cytokine messenger RNA expression in acquired immunodeficiency syndrome dememtia

1993 • 418 citations

Production of hemolymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-1 beta and tumor necrosis factor-alpha.

1992 • 402 citations

HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state.

1995 • 386 citations

Defining protective responses to pathogens: cytokine profiles in leprosy lesions

1991 • 375 citations

Clinical‐neuropathologic correlation in HIV‐associated dementia

1993 • 325 citations

Tumor Necrosis Factor α Inhibits Glutamate Uptake by Primary Human Astrocytes

1996 • 317 citations

Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic

1996 • 310 citations

Evidence for neurotoxic activity of tat from human immunodeficiency virus type 1

1991 • 305 citations

Tumor Necrosis Factor Alpha-Induced Apoptosis in Human Neuronal Cells: Protection by the Antioxidant N-Acetylcysteine and the Genes bcl-2 and crmA

1995 • 300 citations

In situ detection of polymerase chain reaction-amplified HIV-1 nucleic acids and tumor necrosis factor-alpha RNA in the central nervous system.

1994 • 283 citations

Human immunodeficiency virus type 1 tat activates non—N‐methyl‐<scp>D</scp>‐aspartate excitatory amino acid receptors and causes neurotoxicity

1995 • 277 citations

AIDS dementia complex and HIV‐1 brain infection: Clinical‐virological correlations

1995 • 254 citations

Persistent human immunodeficiency virus type 1 infection in human fetal glial cells reactivated by T-cell factor(s) or by the cytokines tumor necrosis factor alpha and interleukin-1 beta

1991 • 254 citations

TNF-Induced Activation of NF-κB

1995 • 240 citations

Effects of tumor necrosis factor, lipopolysaccharide, and IL-4 on the expression of vascular cell adhesion molecule-1 in vivo. Correlation with CD3+ T cell infiltration.

1992 • 227 citations

Induction of interleukin-1 and tumor necrosis factor alpha in brain cultures by human immunodeficiency virus type 1

1992 • 201 citations

Molecular determinants for cellular uptake of Tat protein of human immunodeficiency virus type 1 in brain cells

1997 • 200 citations

Neurotoxic Effects of Tumor Necrosis Factor Alpha in Primary Human Neuronal Cultures are Mediated by Activation of the Glutamate AMPA Receptor Subtype: Implications for AIDS Neuropathogenesis

1993 • 175 citations

TNF-alpha- and IFN-gamma-mediated signal transduction pathways: effects on glial cell gene expression and function.

1995 • 172 citations

Human immunodeficiency virus type 1–infected monocytic cells can destroy human neural cells after cell‐to‐cell adhesion

1992 • 166 citations

Human immunodeficiency virus type 1 Tat protein induces death by apoptosis in primary human neuron cultures

1997 • 149 citations

In vitro evidence for a dual role of tumor necrosis factor‐α in human immunodeficiency virus type 1 encephalopathy

1995 • 138 citations

The Basic Domain of the Lentiviral Tat Protein Is Responsible for Damages in Mouse Brain: Involvement of Cytokines

1994 • 138 citations

Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes

1996 • 127 citations

Tumor necrosis factor facilitates regeneration of injured central nervous system axons

1991 • 117 citations

Increased Expression of Tumor Necrosis Factor-α Receptors in the Brains of Patients With AIDS

1995 • 79 citations

Expression of Tumor Necrosis Factor α (TNFα) and Interleukin 6 (IL-6) mRNA in Adult Human Astrocytes

1996 • 75 citations

Neurotoxicity of the human immunodeficiency virus type 1 Tat transactivator to PC12 cells requires the Tat amino acid 49‐58 basic domain

1995 • 70 citations

Distinct HIV-1 env Sequences Are Associated with Neurotropism and Neurovirulence

1995 • 66 citations

Increased human immunodeficiency virus (HIV) expression in chronically infected U937 cells upon in vitro differentiation by hydroxyvitamin D3: roles of interferon and tumor necrosis factor in regulation of HIV production

1990 • 57 citations

Increased expression of Tα1 α-tubulin mRNA during collateral and NGF-induced sprouting of sympathetic neurons

1990 • 48 citations

Synergistic stimulatory effects of tumour necrosis factor α and interferon γ on replication of human immunodeficiency virus type 1 and on apoptosis of HIV‐1‐infected host cells

1996 • 47 citations

Release of granulocyte-macrophage colony-stimulating factor by alveolar macrophages in the lung of HIV-1-infected patients. A mechanism accounting for macrophage and neutrophil accumulation.

1992 • 42 citations

Astrocyte-conditioned medium stimulates HIV-1 expression in a chronically infected promonocyte clone

1990 • 36 citations

Induction of tumor necrosis factor alpha gene expression by lipoprotein lipase requires protein kinase C activation.

1994 • 29 citations

Lymphocyte Emperipolesis in Human Glial Cells

1993 • 20 citations

Anti-idiotypic antibodies to rubella virus

1989 • 14 citations

Simple protocol for rapid, direct sequencing of immunoglobulin variable-region genes.

1995 • 3 citations