N-Acetyl-L-Aspartic acid: A literature review of a compound prominent in 1H-NMR spectroscopic studies of brain

THE EXCITATION AND DEPRESSION OF SPINAL NEURONES BY STRUCTURALLY RELATED AMINO ACIDS

1960 • 853 citations

Aspartoacylase deficiency and N‐acetylaspartic aciduria in patients with canavan disease

1988 • 400 citations

SPECIFICITY OF AMINO ACID ACYLASES

1952 • 349 citations

N‐Acetyl‐Aspartyl‐Glutamate: Regional Levels in Rat Brain and the Effects of Brain Lesions as Determined by a New HPLC Method

1984 • 344 citations

N-ACETYL-l-ASPARTIC ACID IN BRAIN

1956 • 325 citations

Synthesis of N-acetyl-<scp>l</scp>-aspartate by rat brain mitochondria and its involvement in mitochondrial/cytosolic carbon transport

1979 • 293 citations

STUDIES ON THE DISTRIBUTION OF N-ACETYL-l-ASPARTIC ACID IN BRAIN

1957 • 292 citations

High-resolution 1H nuclear magnetic resonance study of cerebral hypoxia in vivo.

1983 • 283 citations

N‐ACETYL‐<scp>l</scp>‐ASPARTIC ACID CONTENT OF HUMAN NEURAL TUMOURS AND BOVINE PERIPHERAL NERVOUS TISSUES

1972 • 213 citations

Olfactory and hormonal influences on the basal forebrain of the male rat

1969 • 184 citations

A Gas Chromatographic Method for the Determination of N‐Acetyl‐<scp>l</scp>‐Aspartic Acid, N‐Acetyl‐α‐ Aspartylglutamic Acid and β‐Citryl‐<scp>l</scp>‐Glutamic Acid and Their Distributions in the Brain and Other Organs of Various Species of Animals

1981 • 181 citations

PRECURSORS IN VIVO OF GLUTAMATE, ASPARTATE AND THEIR DERIVATIVES OF RAT BRAIN

1966 • 177 citations

FREE AMINO ACIDS AND RELATED COMPOUNDS IN DOG BRAIN: POST‐MORTEM AND ANOXIC CHANGES, EFFECTS OF AMMONIUM CHLORIDE INFUSION, AND LEVELS DURING SEIZURES INDUCED BY PICROTOXIN AND BY PENTYLENETETRAZOL*

1963 • 168 citations

COMPARATIVE NEUROCHEMISTRY

1965 • 166 citations

ACETATE METABOLISM IN THE NERVOUS SYSTEM. N‐ACETYL‐<scp>l</scp>‐ASPARTIC ACID AND THE BIOSYNTHESIS OF BRAIN LIPIDS*

1966 • 159 citations

Effect of Hypoglycemic Encephalopathy upon Amino Acids, High‐Energy Phosphates, and pH_i in the Rat Brain In Vivo: Detection by Sequential ¹H and ³¹P NMR Spectroscopy

1985 • 156 citations

N‐Acetylation of L‐Aspartate in the Nervous System: Differential Distribution of a Specific Enzyme

1985 • 136 citations

DISTRIBUTION OF N‐ACETYL‐ASPARTIC AND N‐ACETYL‐ASPARTYL‐GLUTAMIC ACIDS IN NERVOUS TISSUE*

1965 • 129 citations

N‐acetylaspartic aciduria due to aspartoacylase deficiency — a new aetiology of childhood leukodystrophy

1986 • 120 citations

Acetyl transport mechanisms. Involvement of N-Acetyl aspartic acid in de novo fatty acid biosynthesis in the developing rat brain

1968 • 119 citations

Immunohistochemistry and Biosynthesis of N‐Acetylaspartylglutamate in Spinal Sensory Ganglia

1987 • 116 citations

In vivo solvent-suppressed localized hydrogen nuclear magnetic resonance spectroscopy: a window to metabolism?

1985 • 110 citations

Studies on the Role of N-Acetylaspartic Acid in Mammalian Brain

1959 • 94 citations

Combined ¹H and ³¹P nuclear magnetic resonance spectroscopic studies of bicuculline‐induced seizures in vivo

1986 • 93 citations

The occurrence of N‐acetylaspartate amidohydrolase (Aminoacylase II) in the developing rat¹

1973 • 92 citations

STUDIES ON FREE AMINO ACIDS IN HUMAN BRAIN

1960 • 92 citations

SUBCELLULAR LOCALIZATION OF N‐ACETYL‐ASPARTYL‐GLUTAMATE, N‐ACETYL‐GLUTAMATE AND GLUTATHIONE IN BRAIN

1969 • 88 citations

STUDIES ON THE FUNCTION OF N‐ACETYL ASPARTIC ACID IN BRAIN

1965 • 87 citations

HISTAMINE‐DEPENDENT FORMATION OF N‐ACETYL‐ASPARTYL PEPTIDES IN MOUSE BRAIN

1973 • 80 citations

The Enzymatic Synthesis of N-Acetyl-L-aspartic Acid by Subcellular Preparations of Rat Brain

1969 • 80 citations

AMIDOHYDROLASES OF BRAIN;¹ ENZYMATIC HYDROLYSIS OF N‐ACETYL‐<scp>l</scp>‐ASPARTATE AND OTHER N‐ACYL‐<scp>l</scp>‐AMINO ACIDS

1976 • 79 citations

Hydrolysis of the Brain Dipeptide N‐Acetyl‐l‐Aspartyl‐l‐Glutamate: Subcellular and Regional Distribution, Ontogeny, and the Effect of Lesions on N‐Acetylated‐α‐Linked Acidic Dipeptidase Activity

1988 • 77 citations

N-Acetylaspartic aciduria in a child with a progressive cerebral atrophy

1986 • 75 citations

Neurochemical and Immunocytochemical Studies on the Distribution of N‐Acetyl‐Aspartylglutamate and N‐Acetyl‐Aspartate in Rat Spinal Cord and Some Peripheral Nervous Tissues

1987 • 70 citations

ACETYLATED AND PEPTIDE BOUND GLUTAMATE AND ASPARTATE IN BRAIN

1967 • 68 citations

Biosynthesis of N-Acetyl-l-aspartic Acid

1959 • 65 citations

Developmental Changes of N‐Acetyl‐L‐Aspartic Acid, N‐Acetyl‐α‐Aspartylglutamic Acid and β‐Citryl‐L‐Glutamic Acid in Different Brain Regions and Spinal Cords of Rat and Guinea Pig

1981 • 61 citations

METABOLISM OF THE ASPARTYL MOIETY OF N‐ACETYL‐<scp>l</scp>‐ASPARTIC ACID IN THE RAT BRAIN

1972 • 58 citations

THE MEASUREMENT OF FREE AND N‐ACETYLATED ASPARTIC ACIDS IN THE NERVOUS SYSTEM*

1966 • 55 citations

EFFECT OF DRUGS ON AMINO ACID LEVELS IN THE RAT BRAIN: HYPOGLYCEMIC AGENTS

1961 • 51 citations

Acetyl transport mechanisms Metabolism of acid in the non-nervous tissues of the rat

1968 • 49 citations

Lipogenesis in the brain of suckling rats. Studies on the mechanism of mitochondrial-cytosolic carbon transfer

1980 • 49 citations

The Enzymatic Synthesis of N-Acetyl-l-aspartic Acid by a Water-insoluble Preparation of a Cat Brain Acetone Powder

1967 • 48 citations

Purification and Characterization of the Heat-Stable Factors Essential for the Conversion of Lignoceric Acid to Cerebronic Acid and Glutamic Acid: Identification of N-Acetyl-l-Aspartic Acid

1983 • 48 citations

In vivo ³¹P and in vitro ¹H nuclear magnetic resonance study of hypoglycemia during neonatal seizure

1987 • 44 citations

Synaptosomal Transport of Radiolabel from N‐Acetyl‐Aspartyl‐[³H]Glutamate Suggests a Mechanism of Inactivation of an Excitatory Neuropeptide

1986 • 43 citations

Ontogenesis of N-acetyl-aspartate and N-acetyl-aspartyl-glutamate in rat brain

1984 • 42 citations

Excitatory action of N-acetylaspartylglutamate on Purkinje cells in guinea pig cerebellar slices: an intrasomatic study

1987 • 42 citations

A RELATIONSHIP OF N‐ACETYLASPARTATE BIOSYNTHESIS TO NEURONAL PROTEIN SYNTHESIS¹²

1975 • 41 citations

ISOLATION OF HYDROPHOBIC PROTEINS BINDING AMINO ACIDS: <scp>l</scp>‐ASPARTIC ACID‐BINDING PROTEIN FROM THE RAT CEREBRAL CORTEX

1976 • 40 citations

A COMPARISON BETWEEN THE INCORPORATION OF ¹⁴C FROM GLUCOSE INTO N‐ACETYG‐<scp>l</scp>‐ASPARTIC ACID AND ASPARTIC ACID IN BRAIN PERFUSION EXPERIMENTS

1960 • 37 citations

METABOLISM OFN-ACETYL-<scp>L</scp>-ASPARTIC ACID IN MICE

1966 • 36 citations

N-acetylaspartic acid in G-actin

1966 • 36 citations

The Influences of Insulin Hypoglycaemic Coma, Repeated Electroshocks, and Chlorpromazine or β-Phenylisopropylmethylamine Administration on the Free Amino Acids in the Brain

1959 • 35 citations

Chemical concomitants of convulsive activity in the cerebrum

1960 • 31 citations

Studies on the Free Amino Acids and Related Compounds in the Brains of Fish, Amphibia, Reptile, Aves and Mammal by ion Exchange Chromatography

1959 • 30 citations

THE PARTICIPATION OF N‐ACETYL‐L‐ASPARTIC ACID IN BRAIN METABOLISM

1965 • 29 citations

N-ACETYLASPARTIC ACID. EXPERIMENTS ON BIOSYNTHESIS AND FUNCTION

1964 • 26 citations

Function of N-Acetyl Aspartic Acid in the Brain : Effects of Certain Drugs

1964 • 25 citations

N-Acetylaspartylglutamate

1988 • 23 citations

POSTNATAL CHANGES IN BRAIN N‐ACETYL‐<scp>l</scp>‐ASPARTIC ACID CONTENT OF NORMAL AND HYPOTHYROID SUCKLING RATS

1967 • 22 citations

DISTRIBUTION OF AMINO ACIDS IN THE BRAIN IN DIFFERENT SPECIES

1964 • 22 citations

Nonedited ¹H NMR lactate/n‐acetyl aspartate ratios and the in vivo determination of lactate concentration in brain

1988 • 20 citations

A method for the gas-chromatographic analysis of N-acetylaspartic acid in brain

1966 • 20 citations

Decrease in N–acetyl–<scp>l</scp>–aspartic acid in brain of aggressive mice*

1968 • 20 citations

DISTRIBUTION OF N-ACETYL-l-ASPARTIC ACID IN RAT BRAIN

1966 • 19 citations

N-Acetyl-L-aspartic acid, acid and β-citryl-l-glutamic acid in human urine

1982 • 17 citations

EFFECTS OF AMINES ON THE LEVEL OF N‐ACETYL‐ASPARTATE AND N‐ACETYL‐ ASPARTYL‐GLUTAMATE IN MOUSE BRAIN TISSUE SLICES

1971 • 16 citations

N-Acetyl aspartic, aspartic and glutamic acid brain levels in aggressive mice

1969 • 16 citations

Decrease in N‐Acetyl‐<scp>l</scp>‐Aspartic Acid in Brain of Myodystrophic Mice

1984 • 13 citations

Effects of N‐Acetyl Aspartate, Aspartate, and Glutamate on cAMP and cGMP Levels in Developing Rat Cerebral Cortex

1982 • 12 citations

Biosynthesis of N-acetyl-<scp>L</scp>-aspartic acid in vivo and in brain homogenates

1970 • 11 citations

In vivo Assessment of Focal Brain Lactate Alterations with NMR Proton Spectroscopy

1988 • 11 citations

N-acetylaspartylglutamate. A neuropeptide in the human visual system

1988 • 11 citations

Isolation and Determination of N-Acetyl-l-Aspartic Acid and Related Compounds in Brain

1974 • 11 citations

Brain level of N‐acetyl‐<scp>l</scp>‐aspartate in different strains of mouse and rat

1969 • 10 citations

Metabolism of acetate and N‐acetylaspartate in isolated perfused rat brain¹

1973 • 10 citations

Specific alterations in the levels of N-acetyl-aspartyl-glutamate in the nervous system of the dystrophic mouse

1987 • 10 citations

Inhibition by N-acetyl-aspartate of aspartate binding to a proteolipid fraction from rat cerebral cortex

1984 • 6 citations

Action of L-aspartic, methyl aspartic and acetyl aspartic acids on GABA transaminase histochemical activity in nervous tissue.

1984 • 5 citations

BRAIN AMINO ACID UPTAKE

1967 • 5 citations