Increased Peroxynitrite Activity in AIDS Dementia Complex: Implications for the Neuropathogenesis of HIV-1 Infection

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1996 • 5,498 citations

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

1988 • 2,754 citations

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with Encephalopathy

1986 • 1,694 citations

The AIDS dementia complex: I. Clinical features

1986 • 1,679 citations

Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase

1992 • 1,499 citations

Molecular profile of reactive astrocytes—Implications for their role in neurologic disease

1993 • 1,436 citations

The AIDS Dementia Complex

1988 • 1,387 citations

The Brain in AIDS: Central Nervous System HIV-1 Infection and AIDS Dementia Complex

1988 • 1,244 citations

Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death

1992 • 939 citations

Secretion of Neurotoxins by Mononuclear Phagocytes Infected with HIV-1

1990 • 628 citations

Evidence of neuronal oxidative damage in Alzheimer's disease.

1996 • 602 citations

Astrocyte Responses to CNS Injury

1994 • 596 citations

Cytokine expression in the brain during the acquired immunodeficiency syndrome

1992 • 572 citations

Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: implications for the neuropathogenesis of HIV disease.

1992 • 531 citations

Brain glia release factors with opposing actions upon neuronal survival

1993 • 437 citations

Immunologic NO Synthase: Elevation in Severe AIDS Dementia and Induction by HIV-1 gp41

1996 • 422 citations

Human mononuclear phagocyte inducible nitric oxide synthase (iNOS): analysis of iNOS mRNA, iNOS protein, biopterin, and nitric oxide production by blood monocytes and peritoneal macrophages

1995 • 420 citations

Human immunodeficiency virus type 1 infection of the nervous system: Pathogenetic mechanisms

1993 • 367 citations

The macrophage in the persistence and pathogenesis of HIV infection

1989 • 365 citations

Induction of nitric oxide synthase activity in human astrocytes by interleukin-1β and interferon-γ

1993 • 355 citations

Lucigenin chemiluminescence in the assessment of neutrophil superoxide production

1987 • 354 citations

Regulation of nitric oxide synthase activity in human immunodeficiency virus type 1 (HIV-1)-infected monocytes: implications for HIV-associated neurological disease.

1995 • 337 citations

Tumor Necrosis Factor α Inhibits Glutamate Uptake by Primary Human Astrocytes

1996 • 317 citations

Macrophage- and astrocyte-derived transforming growth factor beta as a mediator of central nervous system dysfunction in acquired immune deficiency syndrome.

1991 • 295 citations

Microglia in human disease, with an emphasis on acquired immune deficiency syndrome.

1991 • 273 citations

Extracellular superoxide dismutase, nitric oxide, and central nervous system O2 toxicity.

1992 • 245 citations

Immunocytochemical Characterization of the Expression of Inducible and Constitutive Isoforms of Nitric Oxide Synthase in Demyelinating Multiple Sclerosis Lesions

1997 • 205 citations

Glia, cytokines, and neurotoxicity.

1995 • 178 citations

Expression of type II nitric oxide synthase in primary human astrocytes and microglia: role of IL-1beta and IL-1 receptor antagonist.

1996 • 174 citations

Study of Receptor-Mediated Neurotoxins Released by HIV-1-Infected Mononuclear Phagocytes Found in Human Brain

1996 • 165 citations

A regulatory role for astrocytes in HIV-1 encephalitis. An overexpression of eicosanoids, platelet-activating factor, and tumor necrosis factor-alpha by activated HIV-1-infected monocytes is attenuated by primary human astrocytes.

1995 • 137 citations

AIDS Dementia Is Associated with Massive, Activated HIV-1 Infection and Concomitant Expression of Several Cytokines

1996 • 128 citations

Interferon (IFN)-α Activation of Human Blood Mononuclear Cells In Vitro and In Vivo for Nitric Oxide Synthase (NOS) Type 2 mRNA and Protein Expression: Possible Relationship of Induced NOS2 to the Anti–Hepatitis C Effects of IFN-α In Vivo

1997 • 121 citations

Brain macrophages: neurotoxic or neurotrophic effector cells?

1994 • 113 citations

Oxidative stress, mutant SOD1, and neurofilament pathology in transgenic mouse models of human motor neuron disease.

1997 • 113 citations

Unraveling the neuroimmune mechanisms for the HIV-1-associated cognitive/motor complex

1995 • 113 citations

In Vivo Aspects of Nitric Oxide (NO) Chemistry: Does Peroxynitrite (^-OONO) Play a Major Role in Cytotoxicity?

1997 • 99 citations

HIV, AIDS, And the Brain

1994 • 88 citations

Co-expression of mRNA for Neurotrophic Factors in Human Neurons and Glial Cells in Culture

1994 • 77 citations

Overexpression of copper-zinc superoxide dismutase in trisomy 21

1996 • 76 citations

Endogenous nitric oxide activates prostaglandin F2 alpha production in human microglial cells but not in astrocytes: a study of interactions between eicosanoids, nitric oxide, and superoxide anion (O2-) regulatory pathways.

1996 • 62 citations

Investigation of the Uncatalyzed Hydration of CO 2 and First Approximations to the Active Site of Carbonic Anhydrase - A Combined Ab initio and DFT Study -

1996 • 47 citations

Cytokine expression and pathogenesis in AIDS brain.

1994 • 46 citations

Human mononuclear phagocyte inducible nitric oxide synthase (iNOS): analysis of iNOS mRNA, iNOS protein, biopterin, and nitric oxide production by blood monocytes and peritoneal macrophages

1995 • 43 citations

Amplification of superoxide anion generation in phagocytic cells by HIV‐1 infection

1993 • 39 citations

Cellular aspects of HIV-1 infection of macrophages leading to neuronal dysfunction in in vitro models for HIV-1 encephalitis

1997 • 32 citations

A continuing enigma: the role of cells of macrophage lineage in the development of HIV disease

1997 • 29 citations

Down-Regulation of Human Immunodeficiency Virus Type I (HIV-1) Production after Stimulation of Monocyte-Derived Macrophages Infected with HIV-1

1993 • 14 citations

Cu, Zn superoxide dismutase in patients with dementia of the Alzheimer type

2009 • 14 citations

N-acetyl-L-cysteine-induced up-regulation of HIV-1 gene expression in monocyte-derived macrophages correlates with increased NF-κB DNA binding activity

1997 • 8 citations

Cu/Zn superoxide dismutase in patients with non-familial Alzheimer’s disease

1995 • 8 citations