Regulation of fatty acid synthesis via phosphorylation of acetyl-CoA carboxylase

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids.

1979 • 1,139 citations

Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

1989 • 848 citations

Protein Phosphatases: Properties and Role in Cellular Regulation

1983 • 645 citations

A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis

1987 • 569 citations

Purification of cyclic 3',5'-nucleotide phosphodiesterase inhibitory protein by affinity chromatography on activator protein coupled to sepharose

1978 • 463 citations

Casein Kinases—Multipotential Protein Kinases

1982 • 454 citations

The Mammary gland : development, regulation, and function

1987 • 396 citations

Regulation of Hepatic Metabolism

1986 • 394 citations

Insulin-Stimulated Hydrolysis of a Novel Glycolipid Generates Modulators of cAMP Phosphodiesterase

1986 • 383 citations

Growth factor-stimulated protein phosphorylation in 3T3-L1 cells. Evidence for protein kinase C-dependent and -independent pathways.

1985 • 351 citations

Regulation of Hepatic Acetyl Coenzyme A Carboxylase by Phosphorylation and Dephosphorylation

1973 • 337 citations

Hormone-Sensitive Lipase: Sequence, Expression, and Chromosomal Localization to 19 cent-q13.3

1988 • 305 citations

Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl‐CoA carboxylase

1988 • 285 citations

Purification to homogeneity of protein kinase C from bovine brain-identity with the phorbol ester receptor.

1984 • 283 citations

Phosphorylation of bovine hormone‐sensitive lipase by the AMP‐activated protein kinase

1989 • 269 citations

The protein phosphatases involved in cellular regulation

1985 • 261 citations

Substrate specificity of a multifunctional calmodulin-dependent protein kinase.

1985 • 243 citations

Purification of Glycogen Synthase Kinase 3 from Rabbit Skeletal Muscle.. Copurification with the Activating Factor (FA)of the (Mg-ATP) Dependent Protein Phosphatase.

1981 • 241 citations

Acetyl Coenzyme A Carboxylase System of Escherichia coli

1974 • 204 citations

Site specificity of casein kinase‐2 (TS) from rat liver cytosol

1986 • 193 citations

The Protein Phosphatases Involved in Cellular Regulation. 5. Purification and Properties of a Ca2+ /Calmodulin-Dependent Protein Phosphatase (2B) from Rabbit Skeletal Muscle

1983 • 186 citations

Insulin and the regulation of adipose-tissue acetyl-coenzyme A carboxylase

1973 • 184 citations

Reconstitution of a Mg‐ATP‐dependent protein phosphatase and its activation through a phosphorylation mechanism

1982 • 183 citations

The protein phosphatases involved in cellular regulation

1985 • 163 citations

Complete Primary Structure of Protein Phosphatase Inhibitor‐1 from Rabbit Skeletal Muscle

1982 • 163 citations

The catalytic subunits of protein phosphatase‐1 and protein phosphatase 2A are distinct gene products

1984 • 160 citations

The structure of the B subunit of calcineurin

1984 • 156 citations

Characterisation of a Reconstituted Mg‐ATP‐Dependent Protein Phosphatase

1983 • 154 citations

The low activity of acetyl‐CoA car☐ylase in basal and glucagon‐stimulated hepatocytes is due to phosphorylation by the AMP‐activated protein kinase and not cyclic AMP‐dependent protein kinase

1988 • 147 citations

Lipogenesis in Rat Hepatocytes

1974 • 147 citations

Modulation of hydroxymethylglutaryl-CoA reductase activity, reductase kinase activity, and cholesterol synthesis in rat hepatocytes in response to insulin and glucagon.

1979 • 143 citations

Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl coenzyme a reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation

1978 • 142 citations

From Dietary Glucose to Liver Glycogen: The Full Circle Round

1987 • 140 citations

Evidence for a role of insulin in the regulation of lipogenesis in lactating rat mammary gland. Measurements of lipogenesis in vivo and plasma hormone concentrations in response to starvation and refeeding

1978 • 134 citations

Inhibition of Rat-Liver Acetyl-Coenzyme-A Carboxylase by Palmitoyl-Coenzyme A. Formation of Equimolar Enzyme-Inhibitor Complex

1978 • 126 citations

Multisite Phosphorylation of Glycogen Synthase from Rabbit Skeletal Muscle

1982 • 123 citations

Evidence that insulin activates fat-cell acetyl-CoA carboxylase by increased phosphorylation at a specific site

1982 • 117 citations

Activation of rat liver cytosolic 3-hydroxy-3-methylglutaryl Coenzyme A reductase kinase by adenosine 5′-monophosphate

1985 • 116 citations

Primary structure of chicken liver acetyl-CoA carboxylase deduced from cDNA sequence.

1988 • 115 citations

Inhibition of rat liver acetyl coenzyme A carboxylase by long chain acyl coenzyme A and fatty acid. Modulation by fatty acid-binding protein.

1977 • 111 citations

Reversible Phosphorylation and Inactivation of Acetyl‐CoA Carboxylase from Lactating Rat Mammary Gland by Cyclic AMP‐Dependent Protein Kinase

1980 • 111 citations

Liver Acetyl Coenzyme A Carboxylase

1968 • 108 citations

Primary structure of the site on bovine hormone‐sensitive lipase phosphorylated by cyclic AMP‐dependent protein kinase

1988 • 104 citations

Glucagon regulation of protein phosphorylation. Identification of acetyl coenzyme A carboxylase as a substrate.

1979 • 104 citations

Acetyl Coenzyme A Carboxylase from Rat Liver

1972 • 102 citations

Analysis of the in vivo phosphorylation state of rabbit skeletal muscle glycogen synthase by fast‐atom‐bombardment mass spectrometry

1988 • 101 citations

Synthesis of fatty acids in the perfused mouse liver

1974 • 100 citations

Inactivation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in vitro. An adenine nucleotide-dependent reaction catalyzed by a factor in human fibroblasts.

1975 • 98 citations

Acyl-CoA-binding protein from cow. Binding characteristics and cellular and tissue distribution

1987 • 98 citations

Adrenaline and the regulation of acetyl-coenzyme A carboxylase in rat epididymal adipose tissue. Inactivation of the enzyme is associated with phosphorylation and can be reversed on dephosphorylation

1979 • 97 citations

Fatty acid synthase — an example of protein evolution by gene fusion

1984 • 95 citations

Glucagon inhibits fatty acid synthesis in isolated hepatocytes via phosphorylation of acetyl-CoA carboxylase by cyclic-AMP-dependent protein kinase

1984 • 95 citations

The protein phosphatases involved in cellular regulation

1985 • 94 citations

Stimulation of site-specific phosphorylation of acetyl coenzyme A carboxylase by insulin and epinephrine.

1983 • 87 citations

The glycogen‐binding subunit of protein phosphatase‐1_g from rabbit skeletal muscle

1989 • 85 citations

Acetyl-CoA carboxylase. Evidence for polymeric filament to protomer transition in the intact avian liver cell.

1978 • 85 citations

Phosphorylation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and modulation of its enzymic activity by calcium-activated and phospholipid-dependent protein kinase.

1985 • 78 citations

Inhibitory effects of long‐chain acyl coenzyme a analogues on rat liver acetyl coenzyme a carboxylase

1979 • 78 citations

Characterization of a Mg2+-dependent phosphatase from turkey gizzard smooth muscle.

1983 • 77 citations

Both insulin and epidermal growth factor stimulate fatty acid synthesis and increase phosphorylation of acetyl‐CoA carboxylase and ATP‐citrate lyase in isolated hepatocytes

1985 • 76 citations

Regulation of acetyl-coenzyme A carboxylase. I. Purification and properties of two forms of acetyl-coenzyme A carboxylase from rat liver.

1988 • 76 citations

Kinetics of activation of acetyl-CoA carboxylase by citrate. Relationship to the rate of polymerization of the enzyme.

1983 • 76 citations

In vitro phosphorylation and inactivation of rat liver acetyl-CoA carboxylase purified by avidin affinity chromatography

1982 • 75 citations

The regulation of fatty acid biosynthesis

1978 • 73 citations

The Protein Phosphatases Involved in Cellular Regulation. 3. Fatty Acid Synthesis, Cholesterol Synthesis and Glycolysis/Gluconeogenesis

1983 • 69 citations

The pathway of adenine nucleotide catabolism and its control in isolated rat hepatocytes subjected to anoxia

1982 • 68 citations

Analysis of sites phosphorylated on acetyl‐CoA carboxylase in response to insulin in isolated adipocytes

1988 • 68 citations

Identification of two isoenzymes of protein phosphatase 2C in both rabbit skeletal muscle and liver

1987 • 66 citations

Purification and properties of a kinase which phosphorylates and inactivates acetyl-CoA carboxylase.

1982 • 64 citations

kinetic Studies on the Reaction Mechanism and the Citrate Activation or Liver Acetyl Coenzyme A Carboxylase

1971 • 63 citations

The polymerization of acetyl-CoA carboxylase.

1983 • 59 citations

Transport and metabolism of glucose by rat small intestine

1983 • 58 citations

Reevaluation of properties of acetyl-CoA carboxylase from rat liver.

1981 • 58 citations

Both insulin and epidermal growth factor stimulate lipogenesis and acetyl-CoA carboxylase activity in isolated adipocytes. Importance of homogenization procedure in avoiding artefacts in acetyl-CoA carboxylase assay

1986 • 56 citations

Resolution of the ATP‐Mg‐dependent phosphorylase phosphatase from liver into a two protein component system

1979 • 56 citations

Putative mediators of insulin action regulate hepatic acetyl CoA carboxylase activity

1983 • 55 citations

Partial structure and hormonal regulation of rabbit liver inhibitor-1; distribution of inhibitor-1 and inhibitor-2 in rabbit and rat tissues

1989 • 55 citations

Studies on insulin-stimulated phosphorylation of acetyl-CoA carboxylase, ATP citrate lyase and other proteins in rat epididymal adipose tissue. Evidence for activation of a cyclic AMP-independent protein kinase

1984 • 55 citations

Fatty Acid, 3‐β‐Hydroxysterol, and Ketone Synthesis in the Perfused Rat Liver

1978 • 55 citations

Regulation of acetyl‐CoA carboxylase: identity of sites phosphorylated in intact cells treated with adrenaline and in vitro by cyclic AMP‐dependent protein kinase

1980 • 50 citations

Negative interactions between phosphorylation of acetyl‐CoA carboxylase by the cyclic AMP‐dependent and AMP‐activated protein kinases

1988 • 50 citations

Hormonal regulation of protein dephosphorylation. Identification and hormonal regulation of protein phosphatase inhibitor-1 in rat adipose tissue.

1983 • 49 citations

Inactivation of hepatic acetyl-CoA carboxylase by catecholamine and its agonists through the alpha-adrenergic receptors.

1981 • 48 citations

Regulation of acetyl-CoA carboxylase in rat mammary gland. Effects of starvation and of insulin and prolactin deficiency on the fraction of the enzyme in the active form in vivo

1982 • 47 citations

An autocrine factor from Reuber hepatoma cells that stimulates DNA synthesis and acetyl-CoA carboxylase. Characterization of biologic activity and evidence for a glycan structure.

1988 • 47 citations

Regulation of lactating-rat mammary-gland lipogenesis by insulin and glucagon in vivo. The role and site of action of insulin in the transition to the starved state

1984 • 47 citations

Purification and subunit structure of rat mammary gland acetyl coenzyme A carboxylase.

1978 • 47 citations

Calmodulin‐dependent multifunctional protein kinase

1986 • 45 citations

Phosphorylation and modulation of the enzymic activity of native and protease-cleaved purified hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase by a calcium/calmodulin-dependent protein kinase.

1987 • 43 citations

Muteins of human interleukin‐1 that show enhanced bioactivities

1987 • 43 citations

Isolation of three cyclic-AMP-independent acetyl-CoA carboxylase kinases from lactating rat mammary gland and characterization of their effects on enzyme activity

1984 • 43 citations

The subunit structure and function of the propionyl coenzyme A carboxylase of Mycobacterium smegmatis.

1982 • 40 citations

Multiple phosphorylation of acetyl-CoA carboxylase in chick liver cells. A cyclic AMP-independent process

1978 • 40 citations

Specific Casein Phosphorylation by a Casein Kinase from Lactating Bovine Mammary Gland

1977 • 40 citations

Coenzyme A activation of acetyl-CoA carboxylase.

1981 • 40 citations

Allosteric activation of rat liver cytosolic 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase by nucleoside diphosphates.

1984 • 39 citations

Purification and properties of acetyl-CoA carboxylase phosphatase.

1981 • 39 citations

Phosphorylation of acetyl-coenzyme A carboxylase by casein kinase I and casein kinase II

1983 • 38 citations

Impaired lipogenesis in mammary glands of lactating rats fed on a cafeteria diet. Reversal of inhibition of glucose metabolism in vitro by insulin

1980 • 37 citations

Evidence that changes in hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity are required partly to maintain a constant rate of sterol synthesis.

1984 • 37 citations

Evidence that activation of acetyl-CoA carboxylase by insulin in adipocytes is mediated by a low-Mr effector and not by increased phosphorylation

1986 • 36 citations

Evidence that glucagon-mediated inhibition of acetyl-CoA carboxylase in isolated adipocytes involves increased phosphorylation of the enzyme by cyclic AMP-dependent protein kinase

1985 • 35 citations

Polymer-protomer transition of acetyl-CoA carboxylase occurs in vivo and varies with nutritional conditions.

1980 • 35 citations

Insulin and phorbol ester stimulate phosphorylation of acetyl‐CoA carboxylase at similar sites in isolated adipocytes

1988 • 34 citations

Evidence for phosphorylation and activation of acetyl CoA carboxylase by a membrane‐associated cyclic AMP‐independent protein kinase

1981 • 34 citations

The purification and properties of a protein kinase and the partial purification of a phosphoprotein phosphatase that inactivate and activate acetyl-CoA carboxylase

1981 • 33 citations

A cold-clamping technique for the rapid sampling of rat liver for studies on enzymes in separate cell fractions. Suitability for the study of enzymes regulated by reversible phosphorylation-dephosphorylation

1984 • 33 citations

The role of acetyl-CoA carboxylase phosphorylation in the control of mammary gland fatty acid synthesis during the starvation and re-feeding of lactating rats

1986 • 31 citations

A new method for the isolation of rat liver acetyl-CoA carboxylase.

1981 • 30 citations

Acute change in the cyclic AMP content of rat mammary acini in vitro. Influence of physiological and pharmacological agents

1985 • 30 citations

Phosphorylation state of acetyl-coenzyme A carboxylase. II. Variation with nutritional condition.

1987 • 29 citations

Phosphorylation state of acetyl-coenzyme A carboxylase. I. Linear inverse relationship to activity ratios at different citrate concentrations.

1987 • 28 citations

Characterization of the phosphorylation of rat mammary ATP‐citrate lyase and acetyl‐CoA carboxylase by Ca²⁺ and calmodulin‐dependent multiprotein kinase and Ca²⁺ and phospholipid‐dependent protein kinase

1986 • 27 citations

Purification and characterization of a protein phosphatase from rat liver acting on key enzymes of glucose metabolism

1984 • 27 citations

Acute effects of starvation and treatment of rats with anti-insulin serum, glucagon and catecholamines on the state of phosphorylation of hepatic 3-hydroxy-3-methylglutaryl-CoA reductase in vivo

1987 • 24 citations

Insulin activation of lipogenesis in isolated mammary acini from lactating rats fed on a high-fat diet. Evidence that acetyl-CoA carboxylase is a site of action

1987 • 23 citations

Phosphorylation and activation of acetyl-coenzyme A carboxylase kinase by the catalytic subunit of cyclic AMP-dependent protein kinase

1983 • 21 citations

Regulation of acetyl-CoA carboxylase in rat mammary gland. Effects of incubation with Ca2+, Mg2+ and ATP on enzyme activity in tissue extracts

1981 • 19 citations

Regulation of acetyl-CoA carboxylase by guanine nucleotides.

1981 • 18 citations

Isolation of Enzymically Active Fragments Formed by Limited Proteolysis of ATP Citrate Lyase

1982 • 14 citations

Fatty Acid Synthesis and Metabolite Fluctuations in Meal-Fed Rats

1977 • 14 citations

Regulation of purified rat liver acetyl CoA carboxylase by phosphorylation

1983 • 13 citations

Modulation of intracellular cyclic AMP content and rate of lipogenesis in mammary acini in vitro

1986 • 13 citations

Isolation of a cyclic-AMP-independent protein kinase from rat liver and its effect on the enzymic activity of acetyl-CoA carboxylase

1986 • 11 citations

Studies on the substrate for hepatic lipogenesis in the rat

1984 • 10 citations

Protein phosphorylation in rat mammary acini and in cytosol preparations in vitro Phosphorylation of acetyl-CoA carboxylase is unaffected by cyclic AMP

1987 • 10 citations

Evidence for the operation of the extrahepatic lipoprotein receptor system in vivo in rats. Effect of dietary cholesterol and orotic acid, alone or in combination, on the rate of synthesis of cholesterol and fatty acid in various tissues, measured by using 3H2O

1979 • 8 citations

Proteolysis of liver acetyl coenzyme A carboxylase by cathepsin B

1985 • 5 citations

Insulin activation of acetyl-CoA carboxylase in isolated mammary acini from lactating rats fed a high-fat diet

1986 • 2 citations