Insulin and phorbol ester stimulate phosphorylation of acetyl‐CoA carboxylase at similar sites in isolated adipocytes

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Phorbol diester receptor copurifies with protein kinase C.

1983 • 1,185 citations

Molecular aspects of cellular regulation

1980 • 394 citations

Phorbol esters, phospholipase C, and growth factors rapidly stimulate the phosphorylation of a Mr 80,000 protein in intact quiescent 3T3 cells.

1983 • 377 citations

Growth factor-stimulated protein phosphorylation in 3T3-L1 cells. Evidence for protein kinase C-dependent and -independent pathways.

1985 • 351 citations

Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl‐CoA carboxylase

1988 • 285 citations

Purification to homogeneity of protein kinase C from bovine brain-identity with the phorbol ester receptor.

1984 • 283 citations

Protein kinase C-stimulated phosphorylation in vitro of a Mr 80,000 protein phosphorylated in response to phorbol esters and growth factors in intact fibroblasts. Distinction from protein kinase C and prominence in brain.

1986 • 277 citations

Protein kinase C phosphorylates pp60src at a novel site

1985 • 243 citations

Insulin and the regulation of adipose-tissue acetyl-coenzyme A carboxylase

1973 • 184 citations

Use of a novel rapid preparation of fat-cell plasma membranes employing Percoll to investigate the effects of insulin and adrenaline on membrane protein phosphorylation within intact fat-cells

1980 • 177 citations

The absence of myristic acid decreases membrane binding of p60src but does not affect tyrosine protein kinase activity

1986 • 174 citations

Molecular Aspects of Cellular Regulation

1986 • 168 citations

Lack of association of epidermal growth factor-, insulin-, and serum-induced mitogenesis with stimulation of phosphoinositide degradation in BALB/c 3T3 fibroblasts.

1986 • 156 citations

Activation of S6 kinase activity in 3T3-L1 cells by insulin and phorbol ester.

1985 • 155 citations

Effects of epinephrine and insulin on phosphopeptide metabolism in adipocytes.

1976 • 133 citations

Evidence that insulin activates fat-cell acetyl-CoA carboxylase by increased phosphorylation at a specific site

1982 • 117 citations

Glucagon inhibits fatty acid synthesis in isolated hepatocytes via phosphorylation of acetyl-CoA carboxylase by cyclic-AMP-dependent protein kinase

1984 • 95 citations

Stimulation of site-specific phosphorylation of acetyl coenzyme A carboxylase by insulin and epinephrine.

1983 • 87 citations

Cell Membranes Methods and Reviews

1983 • 84 citations

Inositol 1,4,5-trisphosphate and intracellular Ca2+ homeostasis in clonal pituitary cells (GH3). Translocation of Ca2+ into mitochondria from a functionally discrete portion of the nonmitochondrial store.

1986 • 80 citations

Tumour-promoting phorbol esters increase basal and inhibit insulin-stimulated lipogenesis in rat adipocytes without decreasing insulin binding

1985 • 77 citations

Both insulin and epidermal growth factor stimulate fatty acid synthesis and increase phosphorylation of acetyl‐CoA carboxylase and ATP‐citrate lyase in isolated hepatocytes

1985 • 76 citations

Tumor-promoting phorbol esters stimulate the phosphorylation of ribosomal protein S6 in quiescent Reuber H35 hepatoma cells.

1984 • 75 citations

In vitro phosphorylation and inactivation of rat liver acetyl-CoA carboxylase purified by avidin affinity chromatography

1982 • 75 citations

Insulin-stimulated phosphoinositide metabolism in isolated fat cells.

1985 • 71 citations

Fat cell protein phosphorylation. Identification of phosphoprotein-2 as ATP-citrate lyase.

1979 • 71 citations

Analysis of sites phosphorylated on acetyl‐CoA carboxylase in response to insulin in isolated adipocytes

1988 • 68 citations

Stoichiometry of contraction and Ca2+ mobilization by inositol 1,4,5-trisphosphate in isolated gastric smooth muscle cells.

1986 • 67 citations

Identification and subcellular distribution of adipocyte peptides and phosphopeptides.

1976 • 67 citations

Modification of glycogen synthase activity in isolated rat hepatocytes by tumor-promoting phorbol esters: evidence for differential regulation of glycogen synthase and phosphorylase.

1983 • 62 citations

Both insulin and epidermal growth factor stimulate lipogenesis and acetyl-CoA carboxylase activity in isolated adipocytes. Importance of homogenization procedure in avoiding artefacts in acetyl-CoA carboxylase assay

1986 • 56 citations

Studies on insulin-stimulated phosphorylation of acetyl-CoA carboxylase, ATP citrate lyase and other proteins in rat epididymal adipose tissue. Evidence for activation of a cyclic AMP-independent protein kinase

1984 • 55 citations

Cell membranes; Methods and reviews

1985 • 54 citations

Effect of insulin on the phosphorylation of adipose tissue protein

1974 • 53 citations

Regulation of acetyl‐CoA carboxylase: identity of sites phosphorylated in intact cells treated with adrenaline and in vitro by cyclic AMP‐dependent protein kinase

1980 • 50 citations

Liver isozyme of rabbit glycogen synthase. Amino acid sequences surrounding phosphorylation sites recognized by cyclic AMP-dependent protein kinase.

1986 • 45 citations

Isolation of three cyclic-AMP-independent acetyl-CoA carboxylase kinases from lactating rat mammary gland and characterization of their effects on enzyme activity

1984 • 43 citations

Evidence that activation of acetyl-CoA carboxylase by insulin in adipocytes is mediated by a low-Mr effector and not by increased phosphorylation

1986 • 36 citations

Evidence that glucagon-mediated inhibition of acetyl-CoA carboxylase in isolated adipocytes involves increased phosphorylation of the enzyme by cyclic AMP-dependent protein kinase

1985 • 35 citations

Reversibility of the insulin-stimulated phosphorylation of ATP citrate lyase and a cytoplasmic protein of subunit Mr 22000 in adipose tissue

1982 • 31 citations

Characterization of the phosphorylation of rat mammary ATP‐citrate lyase and acetyl‐CoA carboxylase by Ca²⁺ and calmodulin‐dependent multiprotein kinase and Ca²⁺ and phospholipid‐dependent protein kinase

1986 • 27 citations

Acute effects of tumor-promoting phorbol esters on hepatic intermediary metabolism

1985 • 16 citations

Fat and phosphorylation - the role of covalent enzyme modification in lipid synthesis

1981 • 16 citations

Stimulation by a tumor-promoting phorbol ester of acetyl-CoA carboxylase activity in isolated rat hepatocytes

1987 • 15 citations

Inhibition of catalase in vitro and in vivo by 4‐hydroxypyrazole, a metabolite of pyrazole

1980 • 12 citations