The role of acetyl-CoA carboxylase phosphorylation in the control of mammary gland fatty acid synthesis during the starvation and re-feeding of lactating rats

Evidence for a role of insulin in the regulation of lipogenesis in lactating rat mammary gland. Measurements of lipogenesis in vivo and plasma hormone concentrations in response to starvation and refeeding

1978 • 134 citations

Evidence that insulin activates fat-cell acetyl-CoA carboxylase by increased phosphorylation at a specific site

1982 • 117 citations

Reversible Phosphorylation and Inactivation of Acetyl‐CoA Carboxylase from Lactating Rat Mammary Gland by Cyclic AMP‐Dependent Protein Kinase

1980 • 111 citations

Glucagon inhibits fatty acid synthesis in isolated hepatocytes via phosphorylation of acetyl-CoA carboxylase by cyclic-AMP-dependent protein kinase

1984 • 95 citations

Effects of Streptozotocin on Carbohydrate and Lipid Metabolism in the Rat

1971 • 94 citations

Stimulation of site-specific phosphorylation of acetyl coenzyme A carboxylase by insulin and epinephrine.

1983 • 87 citations

The mode of regulation of pyruvate dehydrogenase of lactating rat mammary gland. Effects of starvation and insulin

1978 • 77 citations

Both insulin and epidermal growth factor stimulate fatty acid synthesis and increase phosphorylation of acetyl‐CoA carboxylase and ATP‐citrate lyase in isolated hepatocytes

1985 • 76 citations

In vitro phosphorylation and inactivation of rat liver acetyl-CoA carboxylase purified by avidin affinity chromatography

1982 • 75 citations

Purification and Physicochemical Properties of ATP Citrate (pro‐3S) Lyase from Lactating Rat Mammary Gland and Studies of Its Reversible Phosphorylation

1981 • 73 citations

The Protein Phosphatases Involved in Cellular Regulation. 3. Fatty Acid Synthesis, Cholesterol Synthesis and Glycolysis/Gluconeogenesis

1983 • 69 citations

Diurnal variations in food intake and in lipogenesis in mammary gland and liver of lactating rats

1983 • 61 citations

Dephosphorylation and activation of Acetyl‐CoA‐carboxylase from lactating rabbit mammary gland

1979 • 59 citations

Monosaccharide transport in the mammary gland of the intact lactating rat

1984 • 50 citations

Regulation of acetyl‐CoA carboxylase: identity of sites phosphorylated in intact cells treated with adrenaline and in vitro by cyclic AMP‐dependent protein kinase

1980 • 50 citations

Role of pyruvate dehydrogenase and insulin in the regulation of lipogenesis in the lactating mammary gland of the rat during the starved-refed transition

1981 • 48 citations

Regulation of acetyl-CoA carboxylase in rat mammary gland. Effects of starvation and of insulin and prolactin deficiency on the fraction of the enzyme in the active form in vivo

1982 • 47 citations

Regulation of lactating-rat mammary-gland lipogenesis by insulin and glucagon in vivo. The role and site of action of insulin in the transition to the starved state

1984 • 47 citations

Short-term dietary regulation of lipogenesis in the lactating mammary gland of the rat

1983 • 47 citations

Lactose and fatty acid synthesis in lactating-rat mammary gland. Effects of starvation, re-feeding, and administration of insulin, adrenaline, streptozotocin and 2-bromo-α-ergocryptine

1984 • 43 citations

Isolation of three cyclic-AMP-independent acetyl-CoA carboxylase kinases from lactating rat mammary gland and characterization of their effects on enzyme activity

1984 • 43 citations

Regulation of peripheral lipogenesis by glucagon. Inability of the hormone to inhibit lipogenesis in rat mammary acini in vitro in the presence or absence of agents which alter its effects on adipocytes

1984 • 41 citations

Biochemical basis of dietary influences on the synthesis of the macronutrients of rat milk.

1984 • 36 citations

Evidence that glucagon-mediated inhibition of acetyl-CoA carboxylase in isolated adipocytes involves increased phosphorylation of the enzyme by cyclic AMP-dependent protein kinase

1985 • 35 citations

Effects of starvation, insulin or prolactin deficiency on the activity of acetyl‐CoA carboxylase in mammary gland and liver of lactating rats

1982 • 31 citations

Acute change in the cyclic AMP content of rat mammary acini in vitro. Influence of physiological and pharmacological agents

1985 • 30 citations

Alterations in mammary-gland blood flow and glucose metabolism in the lactating rat induced by short-term starvation and refeeding

1984 • 25 citations

Regulation of acetyl-CoA carboxylase in rat mammary gland. Effects of incubation with Ca2+, Mg2+ and ATP on enzyme activity in tissue extracts

1981 • 19 citations

Cited By (0)

Loading...