α-Tocopheryl Succinate, the Most Effective Form of Vitamin E for Adjuvant Cancer Treatment: A Review

On the Existence of a Hitherto Unrecognized Dietary Factor Essential for Reproduction

1922 • 943 citations

Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: A p53-independent induction of p21WAF1/CIP1 via C/EBPβ

1997 • 340 citations

d-alpha-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties.

1995 • 290 citations

Induction of cancer cell apoptosis by α‐tocopheryl succinate: molecular pathways and structural requirements

2001 • 286 citations

Inhibition of NF-κB Activation by Vitamin E Derivatives

1993 • 243 citations

Selective cancer cell killing by α-tocopheryl succinate

2001 • 236 citations

THE ISOLATION FROM WHEAT GERM OIL OF AN ALCOHOL, α-TOCOPHEROL, HAVING THE PROPERTIES OF VITAMIN E

1936 • 226 citations

Effects of tocopherol (vitamin E) acid succinate on morphological alterations and growth inhibition in melanoma cells in culture.

1982 • 196 citations

Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo.

2002 • 186 citations

Selenium and vitamin E inhibit radiogenic and chemically induced transformation in vitro via different mechanisms.

1986 • 183 citations

Vitamin E succinate inhibits the function of androgen receptor and the expression of prostate-specific antigen in prostate cancer cells

2002 • 154 citations

Vitamin E Succinate Promotes Breast Cancer Tumor Dormancy

2000 • 153 citations

Vitamin E Succinate Induces Apoptosis in Human Prostate Cancer Cells: Role for Fas in Vitamin E Succinate-Triggered Apoptosis

2000 • 148 citations

Vitamin E succinate (VES) induces Fas sensitivity in human breast cancer cells: role for Mr 43,000 Fas in VES-triggered apoptosis.

1999 • 146 citations

The selective antiproliferative effects of alpha-tocopheryl hemisuccinate and cholesteryl hemisuccinate on murine leukemia cells result from the action of the intact compounds.

1994 • 137 citations

On the Constitution of α-Tocopherol

1938 • 136 citations

Vitamin E inhibits melanoma growth in mice

2002 • 135 citations

Vitamin E and cancer prevention: recent advances and future potentials.

1992 • 132 citations

Activation of extracellular signal-regulated kinase and c-Jun-NH(2)-terminal kinase but not p38 mitogen-activated protein kinases is required for RRR-alpha-tocopheryl succinate-induced apoptosis of human breast cancer cells.

2001 • 127 citations

α‐Tocopheryl succinate‐induced apoptosis in Jurkat T cells involves caspase‐3 activation, and both lysosomal and mitochondrial destabilisation

1999 • 125 citations

Vitamin E succinate induces Fas-mediated apoptosis in estrogen receptor-negative human breast cancer cells.

1997 • 123 citations

Vitamin E: Mechanisms of Action as Tumor Cell Growth Inhibitors

2001 • 115 citations

Growth inhibition and apoptosis of RL human B lymphoma cells by vitamin E succinate and retinoic acid: role for transforming growth factor beta.

1995 • 94 citations

Modification of the effect of tamoxifen,cis‐platin, DTIC, and interferon‐α2b on human melanoma cells in culture by a mixture of vitamins

1994 • 90 citations

Vitamin E Succinate Inhibits Colon Cancer Liver Metastases

2002 • 85 citations

Vitamin E inhibits experimental carcinogenesis and tumour angiogenesis

1996 • 84 citations

Vitamin E Enhances the Chemotherapeutic Effects of Adriamycin on Human Prostatic Carcinoma Cells in Vitro

1986 • 81 citations

RRR‐α‐Tocopheryl succinate inhibits proliferation and enhances secretion of transforming growth factor‐β (TGF‐β) by human breast cancer cells

1993 • 78 citations

Inhibition of Inflammatory Endothelial Responses by a Pathway Involving Caspase Activation and p65 Cleavage

2001 • 74 citations

Mechanism of α-tocopheryl succinate-induced apoptosis of promyelocytic leukemia cells

2000 • 74 citations

Does lack of tocopherols and tocotrienols put women at increased risk of breast cancer?

2002 • 73 citations

Evidence for role of transforming growth factor‐β in RRR‐a‐tocopheryl succinate‐induced apoptosis of human mda‐mb‐435 breast cancer cells

1997 • 72 citations

Inhibition of NF-kappa B DNA binding activity by alpha-tocopheryl succinate.

1993 • 72 citations

Regression by vitamin E of experimental oral cancer.

1987 • 69 citations

Role of Vitamin E in the Prophylaxis of Cancer

1991 • 69 citations

RRR‐α‐tocopheryl succinate inhibits el4 thymic lymphoma cell growth by inducing apoptosis and DNA synthesis arrest

1997 • 65 citations

Effect of individual and multiple antioxidant vitamins on growth and morphology of human nontumorigenic and tumorigenic parotid acinar cells in culture

1996 • 64 citations

D-Alpha-Tocopheryl Succinate (Vitamin E) Enhances Radiation-Induced Chromosomal Damage Levels in Human Cancer Cells, but Reduces it in Normal Cells

2002 • 63 citations

Lipoprotein-associated α-tocopheryl-succinate inhibits cell growth and induces apoptosis in human MCF-7 and HBL-100 breast cancer cells

2000 • 62 citations

Inhibition of NF‐_κB transcriptional activity by α‐tocopheryl succinate

1998 • 59 citations

c-Jun involvement in vitamin E succinate induced apoptosis of reticuloendotheliosis virus transformed avian lymphoid cells

1997 • 56 citations

Growth‐inhibitory effects of vitamin E succinate on retrovirus‐transformed tumor cellsin vitro

1990 • 54 citations

Apoptosis induced at different dose rates: implication for the shoulder region of cell survival curves

1994 • 53 citations

α-Tocopheryl succinate epitomizes a compound with a shift in biological activity due to pro-vitamin-to-vitamin conversion

2002 • 50 citations

Suppression of X-ray induced transformation by vitamin E in mouse C3H/10T12 cells

1986 • 44 citations

Decreased expressions of c-myc and H-ras oncogenes in vitamin E succinate induced morphologically differentiated murine B-16 melanoma cells in culture

1990 • 44 citations

Inhibitory effects of RRR-α-tocopheryl succinate on benzo(a)pyrene (B(a)P)-induced forestomach carcinogenesis in female mice

2001 • 42 citations

Vitamin E Increases the Growth Inhibitory and Differentiating Effects of Tumor Therapeutic Agents on Neuroblastoma and Glioma Cells in Culture

1980 • 41 citations

Vitamin E (d-a-Tocopheryl Succinate) Decreases Mitotic Accumulation in g-Irradiated Human Tumor, but Not in Normal, Cells

1999 • 41 citations

Modification of radiosensitivity and recovery from X ray damage in vitro by retinoic acid

1989 • 41 citations

p53 in the anticancer mechanism of vitamin E

1993 • 40 citations

Study on the Specificity of -Tocopheryl (Vitamin E) Acid Succinate Effects on Melanoma, Glioma and Neuroblastoma Cells in Culture

1983 • 40 citations

RRR-α-tocopheryl succinate inhibits human gastric cancer SGC-7901 cell growth by inducing apoptosis and DNA synthesis arrest

2002 • 37 citations

RRR‐α‐tocopheryl succinate inhibits DNA synthesis and enhances the production and secretion of biologically active transforming growth factor‐β by avian retrovirus‐transformed lymphoid cells

1995 • 37 citations

Potentiation of the Effect of Paclitaxel and Carboplatin by Antioxidant Mixture on Human Lung Cancer H520 Cells

2002 • 36 citations

Effect of vitamin E succinate and a cAMP‐Stimulating agent on the expression of c‐myc, N‐myc and H‐ras in murine neuroblastoma cells

1991 • 33 citations

Modification of the expression of adenosine 3′,5′-cyclic monophosphate-induced differentiated functions in neuroblastoma cells by beta-carotene and D-alpha-tocopheryl succinate.

1994 • 31 citations

Peptide YY Augments Gross Inhibition by Vitamin E Succinate of Human Pancreatic Cancer Cell Growth

2000 • 28 citations

Vitamin E Induces Morphological Differentiation and Increases the Effect of Ionizing Radiation on Neuroblastoma Cells in Culture

1979 • 27 citations

Vitamin E and Human Neuroblastoma

2015 • 25 citations

Effect of alpha tocopheryl succinate on adenylate cyclase activity in murine neuroblastoma cells in culture.

1988 • 25 citations

Effect of vitamin E succinate on expression of TGF-β₁, c-Jun and JNK1 in human gastric cancer SGC-7901 cells

2001 • 23 citations

Alpha tocopheryl succinate inhibits melanocyte-stimulating hormone (MSH)-sensitive adenylate cyclase activity in melanoma cells

1987 • 22 citations

Vitamin E and the Y4 Agonist BA-129 Decrease Prostate Cancer Growth and Production of Vascular Endothelial Growth Factor

2002 • 22 citations

Vitamin E Succinate Inhibits Protein Kinase C: Correlation with its Unique Inhibitory Effects on Cell Growth and Transformation

1995 • 21 citations

Effect of alpha tocopheryl succinate on cyclic AMP-dependent protein kinase activity in murine B-16 melanoma cells in culture

1988 • 21 citations

dl- -Tocopheryl Succinate Enhances the Effect of -lrradiation on Neuroblastoma Cells in Culture

1984 • 19 citations

Alpha-Tocopherol Succinate Inhibits Growth of Gastric Cancer Cells in Vitro

2001 • 18 citations

Effects of DL‐alpha‐tocopheryl succinate in combination with sodium butyrate and camp stimulating agent on neuroblastoma cells in culture

1984 • 17 citations

Clinical development plan: Vitamin E

1994 • 16 citations

Effect of hyperthemia in combination with vitamin E and cyclic amp on neuroblastoma cells in culture

1984 • 14 citations

Induction of differentiated phenotypes in melanoma cells by a combination of an adenosine 3′,5′-cyclic monophosphate stimulating agent and D-alpha tocopheryl succinate

1989 • 14 citations

Combined effect of adenosine 3′, 5′-cyclic monophosphate stimulating agents, vitamin e succinate, and heat on the survival of murine b-16 melanoma cells in culture

1988 • 13 citations

Biphasic action of vitamin E on the growth of human oral squamous carcinoma cells.

1999 • 12 citations

Alpha Tocopheryl Succinate, Retinoic Acid and Polar Carotenoids Enhanced the Growth-Inhibitory Effect of a Cholesterol-Lowering Drug on Immortalized and Transformed Nerve Cells in Culture

2001 • 11 citations

Retinoic Acid and Vitamin E Modulate Expression and Release of CD178 in Carcinoma Cells: Consequences for Induction of Apoptosis in CD95-Sensitive Cells

2001 • 10 citations

Vitamins Induce Cell Differentiation, Growth Inhibition and Enhance the Effect of Tumor Therapeutic Agents on Some Cancer Cells in Vitro

1995 • 7 citations

Increased sensitivity of EBNA2-transformed rat fibroblasts to ionizing radiation

1996 • 6 citations