Vitamin E metabolism

Oxidative stress: oxidants and antioxidants

1997 • 4,454 citations

Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality

2005 • 2,499 citations

Simvastatin and Niacin, Antioxidant Vitamins, or the Combination for the Prevention of Coronary Disease

2001 • 1,999 citations

Continuous Monitoring ofin VztroOxidation of Human Low Density Lipoprotein

1989 • 1,824 citations

Drug Metabolism and Variability among Patients in Drug Response

2005 • 1,138 citations

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

2000 • 929 citations

The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma

1987 • 889 citations

Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidant or not?

2005 • 699 citations

Tocotrienols: Vitamin E beyond tocopherols

2006 • 694 citations

HYPOFERRÆMIA IN OBESE ADOLESCENTS

1962 • 650 citations

Absorption, lipoprotein transport, and regulation of plasma concentrations of vitamin E in humans.

1993 • 591 citations

Urinary sodium excretion and cardiovascular mortality in Finland: a prospective study

2001 • 588 citations

γ-Tocopherol traps mutagenic electrophiles such as NO _x and complements α-tocopherol: Physiological implications

1997 • 533 citations

γ-Tocopherol and its major metabolite, in contrast to α-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells

2000 • 512 citations

Cytochrome P450 ω-Hydroxylase Pathway of Tocopherol Catabolism

2002 • 447 citations

The Oxidative Modification Hypothesis of Atherosclerosis Does It Hold for Humans?

2001 • 435 citations

Gamma-tocopherol detoxification of nitrogen dioxide: superiority to alpha-tocopherol.

1993 • 337 citations

γ‐Tocopherol, but not α‐tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats

2003 • 318 citations

Preferential incorporation of alpha-tocopherol vs gamma-tocopherol in human lipoproteins

1989 • 301 citations

Novel urinary metabolite of alpha-tocopherol, 2,5,7,8-tetramethyl-2(2’-carboxyethyl)-6-hydroxychroman, as an indicator of an adequate vitamin E supply?

1995 • 245 citations

Vitamin E activates gene expression via the pregnane X receptor

2002 • 226 citations

Cytochrome P4503A-Dependent Metabolism of Tocopherols and Inhibition by Sesamin

2000 • 213 citations

Sebaceous Gland Secretion is a Major Physiologic Route of Vitamin E Delivery to Skin

1999 • 204 citations

Urinary excretion of 2,7,8-trimethyl-2-(β-carboxyethyl)-6-hydroxychroman is a major route of elimination of γ-tocopherol in humans

1999 • 199 citations

A new endogenous natriuretic factor: LLU-alpha.

1996 • 194 citations

Tocopherols are metabolized in HepG2 cells by side chain ω-oxidation and consecutive β-oxidation

2001 • 182 citations

α-Tocopherol Metabolism Is Abnormal in Scavenger Receptor Class B Type I (SR-BI)-Deficient Mice

2002 • 179 citations

Oxidative stress: new approaches to diagnosis and prognosis in atherosclerosis

2003 • 175 citations

Depletion of Human Stratum Corneum Vitamin E: An Early and Sensitive In Vivo Marker of UV Induced Photo-Oxidation

1998 • 175 citations

Mechanism of arylating quinone toxicity involving Michael adduct formation and induction of endoplasmic reticulum stress

2006 • 170 citations

Effects of Dietary Sesame Seeds on Plasma Tocopherol Levels

2001 • 168 citations

Gas Chromatography–Mass Spectrometry Analysis of Vitamin E and Its Oxidation Products

1996 • 160 citations

THE METABOLISM OF VITAMIN E

1956 • 153 citations

Sesame Ingestion Affects Sex Hormones, Antioxidant Status, and Blood Lipids in Postmenopausal Women

2006 • 148 citations

The effect of vitamin E on blood pressure in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial

2006 • 141 citations

Synthetic as compared with natural vitamin E is preferentially excreted as α‐CEHC in human urine: studies using deuterated α‐tocopheryl acetates

1998 • 133 citations

THE METABOLISM OF VITAMIN E

1956 • 132 citations

α‐ and γ‐tocotrienols are metabolized to carboxyethyl‐hydroxychroman derivatives and excreted in human urine

2001 • 129 citations

On the mechanism of the anticlotting action of vitamin E quinone.

1995 • 125 citations

The Nitration Product 5-Nitro-γ-tocopherol Is Increased in the Alzheimer Brain

2002 • 125 citations

Essential Nutrients: Food or Supplements?

2005 • 124 citations

α-Tocopherol transfer protein stimulates the secretion of α-tocopherol from a cultured liver cell line through a brefeldin A-insensitive pathway

1997 • 117 citations

The effect of α- and γ-tocopherol and their carboxyethyl hydroxychroman metabolites on prostate cancer cell proliferation

2004 • 112 citations

Corn and Sesame Oils Increase Serum γ-Tocopherol Concentrations in Healthy Swedish Women

2001 • 101 citations

Products of γ-tocopherol reaction with NO2 and their formation in rat insulinoma (RINm5F) cells

1995 • 101 citations

Quantification of the α- and γ-Tocopherol Metabolites 2,5,7,8-Tetramethyl-2-(2′-carboxyethyl)-6-hydroxychroman and 2,7,8-Trimethyl-2-(2′-carboxyethyl)-6-hydroxychroman in Human Serum

1999 • 96 citations

Vitamin E Oxidation in Human Atherosclerotic Lesions

2002 • 93 citations

Anti-inflammatory effects of tocopherol metabolites

2004 • 89 citations

Dietary Sesame Seed and Its Lignans Inhibit 2,7,8-Trimethyl- 2(2′-carboxyethyl)-6-hydroxychroman Excretion into Urine of Rats Fed γ-Tocopherol

2002 • 87 citations

Gas chromatography mass spectrometry analysis of carboxyethyl-hydroxychroman metabolites of α- and γ-tocopherol in human plasma

2002 • 86 citations

α-Tocopheryl hydroquinone is an efficient multifunctional inhibitor of radical-initiated oxidation of low density lipoprotein lipids

1997 • 84 citations

The Absorption of α-Tocopherol in Control Subjects and in Patients with Intestinal Malabsorption

1970 • 79 citations

A rapid method for the extraction and determination of vitamin E metabolites in human urine

2000 • 78 citations

Urinary α-tocopherol metabolites in α-tocopherol transfer protein-deficient patients

2000 • 75 citations

Comparison of Gas Chromatography–Mass Spectrometry and Liquid Chromatography–Tandem Mass Spectrometry Methods to Quantify α-Tocopherol and α-Tocopherolquinone Levels in Human Plasma

2002 • 73 citations

Synthesis and analysis of conjugates of the major vitamin E metabolite, α-CEHC

2002 • 69 citations

A Novel 5′-Carboxychroman Metabolite of γ-Tocopherol Secreted by HepG2 Cells and Excreted in Human Urine

2000 • 69 citations

Modulation of Cyp3a11 mRNA expression by α-tocopherol but not γ-tocotrienol in mice

2004 • 68 citations

Biliary Secretion of α-Tocopherol and the Role of the mdr2 P-Glycoprotein in Rats and Mice

1998 • 68 citations

The absorption of α-tocopherol in man

1970 • 68 citations

Endogenous natriuretic factors 7: biospecificity of a natriuretic gamma-tocopherol metabolite LLU-alpha.

1997 • 67 citations

Is α-tocopherol a reservoir for α-tocopheryl hydroquinone?

1995 • 64 citations

Dietary flavonoids with a catechol structure increase α-tocopherol in rats and protect the vitamin from oxidation in vitro

2006 • 63 citations

5-nitro-γ-tocopherol increases in human plasma exposed to cigarette smoke in vitro and in vivo

2003 • 61 citations

Evidence for the nitration of γ-tocopherol in vivo: 5-nitro-γ-tocopherol is elevated in the plasma of subjects with coronary heart disease

2002 • 52 citations

Antioxidant and cytotoxic tocopheryl quinones in normal and cancer cells

1995 • 49 citations

A New Method for the Analysis of Urinary Vitamin E Metabolites and the Tentative Identification of a Novel Group of Compounds

2000 • 47 citations

Simultaneous determination of homologues of vitamin E and coenzyme Q and products of α-tocopherol oxidation

1998 • 46 citations

Effects of antioxidant supplementation on blood cyclosporin A and glomerular filtration rate in renal transplant recipients

2005 • 42 citations

γ-Tocotrienol, a vitamin E homolog, is a natriuretic hormone precursor

2003 • 41 citations

Supplementation with mixed tocopherols increases serum and blood cell γ-tocopherol but does not alter biomarkers of platelet activation in subjects with type 2 diabetes

2006 • 39 citations

Mutagenicity of Tocopheryl Quinones: Evolutionary Advantage of Selective Accumulation of Dietary a-Tocopherol

2002 • 37 citations

Effect of 6 weeks of vitamin E administration on renal haemodynamic alterations following a single dose of neoral in healthy volunteers

2001 • 35 citations

Dietary (+)-Catechin and BHT Markedly Increase α-Tocopherol Concentrations in Rats by a Tocopherol-ω-Hydroxylase–Independent Mechanism

2003 • 32 citations

α-Tocopheryl Quinone is Converted into Vitamin E in Man

1997 • 32 citations

The Effect of α-Tocopherol, α-Tocopherylhydroquinone and Their Esters on Experimental Muscular Dystrophy in the Rat

1959 • 15 citations

Nitration of γ-tocopherol prevents its oxidative metabolism by HepG2 cells

2005 • 9 citations