Tocopherol (Vitamin E) in Alzheimer???s Disease and Other Neurodegenerative Disorders

Pharmacological interventions for somatoform disorders in adults

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A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease

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The Cochrane Database of Systematic Reviews

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MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20 536 high-risk individuals: a randomised placebo-controlled trial

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Practice guideline for the treatment of patients with schizophrenia. American Psychiatric Association

1997 • 1,357 citations

Effects of Tocopherol and Deprenyl on the Progression of Disability in Early Parkinson's Disease

1993 • 1,208 citations

Dietary Intake of Antioxidants and Risk of Alzheimer Disease

2002 • 1,068 citations

MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20536 high-risk individuals: a randomised placebo-controlled trial

2002 • 1,028 citations

Oxidative stress and the pathogenesis of Parkinson's disease

1996 • 967 citations

Role of oxygen free radicals in carcinogenesis and brain ischemia

1990 • 885 citations

Antioxidants, Oxidative Stress, and Degenerative Neurological Disorders

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Brain Regional Correspondence Between Alzheimer's Disease Histopathology and Biomarkers of Protein Oxidation

1995 • 784 citations

γ-Tocopherol, the major form of vitamin E in the US diet, deserves more attention

2001 • 757 citations

Reduced Risk of Alzheimer Disease in Users of Antioxidant Vitamin Supplements

2004 • 725 citations

Review: Alzheimer's Amyloid β-Peptide-Associated Free Radical Oxidative Stress and Neurotoxicity

2000 • 714 citations

Dietary Intake of Antioxidant Nutrients and the Risk of Incident Alzheimer Disease in a Biracial Community Study

2002 • 680 citations

The antioxidant paradox

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Evidence of neuronal oxidative damage in Alzheimer's disease.

1996 • 602 citations

Nitric oxide and oxygen radicals: a question of balance

1995 • 568 citations

Vitamin E in Humans: Demand and Delivery

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Polyunsaturated Fatty Acids, Antioxidants, and Cognitive Function in Very Old Men

1997 • 458 citations

Autopsy Samples of Alzheimer's Cortex Show Increased Peroxidation In Vitro

1990 • 456 citations

Antioxidant Vitamin Intake and Risk of Alzheimer Disease

2003 • 416 citations

An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration

1999 • 393 citations

Protective Effects of Grape Seed Proanthocyanidins and Selected Antioxidants against TPA-Induced Hepatic and Brain Lipid Peroxidation and DNA Fragmentation, and Peritoneal Macrophage Activation in Mice

1998 • 380 citations

Oxidative injury in diseases of the central nervous system: focus on alzheimer’s disease

2000 • 378 citations

FAT-SOLUBLE VITAMINS

1934 • 377 citations

Impact of deprenyl and tocopherol treatment on Parkinson's disease in DATATOP patients requiring levodopa

1996 • 353 citations

β-Amyloid-Associated Free Radical Oxidative Stress and Neurotoxicity: Implications for Alzheimer's Disease

1997 • 350 citations

Vitamin E and Cognitive Decline in Older Persons

2002 • 342 citations

Vitamin E and Vitamin C Supplement Use and Risk of Incident Alzheimer Disease

1998 • 337 citations

Association of vitamin E and C supplement use with cognitive function and dementia in elderly men

2000 • 318 citations

Cypermethrin-induced oxidative stress in rat brain and liver is prevented by Vitamin E or allopurinol

2001 • 314 citations

Principles and Practice of Geriatric Medicine

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Vitamin E

1995 • 309 citations

Safety of oral intake of vitamin E

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Dietary lipids and antioxidants in Parkinson's disease: A population‐based, case‐control study

1996 • 295 citations

Vitamin E and Alzheimer disease: the basis for additional clinical trials

2000 • 263 citations

Dietary Antioxidants and Cognitive Function in a Population-based Sample of Older Persons: The Rotterdam Study

1996 • 254 citations

Lipid Peroxidation and Free Radical Scavengers in Alzheimer’s Disease

1989 • 250 citations

MPTP-induced parkinsonism in human and non-human primates--clinical and experimental aspects.

1984 • 250 citations

Protective effects of idebenone and α‐tocopherol on β‐amyloid‐(1–42)‐induced learning and memory deficits in rats: implication of oxidative stress in β‐amyloid‐induced neurotoxicity in vivo

1999 • 240 citations

Association of Antioxidants with Memory in a Multiethnic Elderly Sample Using the Third National Health and Nutrition Examination Survey

1999 • 239 citations

Tolerance and safety of vitamin E: A toxicological position report

1992 • 237 citations

Dietary Antioxidants and Parkinson Disease

1997 • 235 citations

Intakes of vitamins E and C, carotenoids, vitamin supplements, and PD risk

2002 • 231 citations

High-dose antioxidant supplements and cognitive function in community-dwelling elderly women

2003 • 216 citations

A pilot trial of high-dose alpha-tocopherol and ascorbate in early Parkinson's disease

1992 • 214 citations

Oxidative Mechanisms and Tardive Dyskinesia

2003 • 208 citations

Effect of dietary vitamin E on expiration of pentane and ethane by the rat

1977 • 206 citations

Plasma Concentrations of Vitamins A and E and Carotenoids in Alzheimer's Disease

1992 • 201 citations

Increased lipoprotein oxidation in alzheimer’s disease

2000 • 196 citations

Diet and Parkinson's disease II

1996 • 191 citations

Chronic antioxidant treatment improves the cognitive performance of aged rats

1995 • 186 citations

Alzheimer’s and Parkinson’s disease

1991 • 186 citations

Protective effect of α-tocopherol on ischemic neuronal damage in the gerbil hippocampus

1990 • 180 citations

Low plasma vitamin C in Alzheimer patients despite an adequate diet

1998 • 160 citations

Vitamin E and human health: Rationale for determining recommended intake levels

1997 • 154 citations

Induction of NF-κB Activity during Haloperidol-Induced Oxidative Toxicity in Clonal Hippocampal Cells: Suppression of NF-κB and Neuroprotection by Antioxidants

1998 • 153 citations

Lipofuscin as an Indicator of Oxidative Stress and Aging

1990 • 137 citations

Antioxidant Therapy in Neurologic Disease

2000 • 134 citations

Trial of d-alpha-tocopherol in Huntington's disease

1995 • 132 citations

The Nitration Product 5-Nitro-γ-tocopherol Is Increased in the Alzheimer Brain

2002 • 125 citations

Vitamin E for neuroleptic-induced tardive dyskinesia

2011 • 121 citations

Vitamin E Treatment for Tardive Dyskinesia

1999 • 118 citations

Case-Control Study of Early Life Dietary Factors in Parkinson's Disease

1988 • 116 citations

Current Status of Antioxidant Therapy for Alzheimer's Disease

1998 • 116 citations

The antioxidant vitamin E modulates amyloid beta-peptide-induced creatine kinase activity inhibition and increased protein oxidation: implications for the free radical hypothesis of Alzheimer's disease.

1999 • 111 citations

Effects of dietary vitamin E, selenium, and polyunsaturated fats on in vivo lipid peroxidation in the rat as measured by pentane production

1978 • 110 citations

Vitamin E in the Treatment of Tardive Dyskinesia: The Possible Involvement of Free Radical Mechanisms

1988 • 108 citations

Oxidative biochemical markers; clues to understanding aging in long-lived species

2001 • 107 citations

Oxidative stress protection and vulnerability in aging: putative nutritional implications for intervention

2000 • 107 citations

Cerebrospinal fluid levels of alpha-tocopherol (vitamin E) in Alzheimer's disease

1997 • 105 citations

Vitamin E and Other Antioxidants in Neuroprotection

1999 • 104 citations

A double-blind placebo-controlled study of vitamin E treatment of tardive dyskinesia.

1996 • 104 citations

Dietary antioxidants and other dietary factors in the etiology of Parkinson's disease

1997 • 101 citations

Neurotoxicity of 24-hydroxycholesterol, an important cholesterol elimination product of the brain, may be prevented by vitamin E and estradiol-17β

2001 • 99 citations

Evaluation of antioxidants, protein, and lipid oxidation products in blood from sporadic amyotrophic lateral sclerosis patients.

1997 • 98 citations

Oxidative Injury of Synapse and Alteration of Antioxidative Defense Systems in Rats, and Its Prevention by Vitamin E

1997 • 95 citations

High doses of vitamin E in the treatment of disorders of the central nervous system in the aged

1999 • 93 citations

Increased Susceptibility of Alzheimer's Disease Temporal Cortex to Oxygen Free Radical-Mediated Processes

1997 • 91 citations

Case‐control study of idiopathic Parkinson's disease and dietary vitamin E intake

1996 • 91 citations

Melatonin and vitamin E limit nitric oxide-induced lipid peroxidation in rat brain homogenates

1997 • 90 citations

Time-Level Relationship for Lipid Peroxidation and the Protective Effect of α-Tocopherol in Experimental Mild and Severe Brain Injury

1998 • 90 citations

Dietary antioxidant supplementation reverses age-related neuronal changes

1998 • 86 citations

Long-term treatment effects of vitamin E for tardive dyskinesia

1998 • 84 citations

Vitamin E for Alzheimer's disease and mild cognitive impairment

2000 • 80 citations

Alpha-tocopherol in the ventricular cerebrospinal fluid of Parkinson's disease patients

1996 • 79 citations

Vitamin E protects neurons against oxidative cell death in vitro more effectively than 17-β estradiol and induces the activity of the transcription factor NF-κB

2000 • 78 citations

Vitamin E protects against Alzheimer's amyloid peptide (25–35)-induced changes in neocortical synaptosomal membrane lipid structure and composition

1998 • 78 citations

Vitamin E prevents apoptosis in hippocampal neurons caused by cerebral ischemia and reperfusion in stroke-prone spontaneously hypertensive rats.

1999 • 78 citations

IRFI 042, a novel dual vitamin E-like antioxidant, inhibits activation of nuclear factor-κB and reduces the inflammatory response in myocardial ischemia–reperfusion injury

2000 • 75 citations

Vitamin E: the radical protector

1998 • 74 citations

THE EFFECT OF VITAMIN E ON WARFARIN‐INDUCED VITAMIN K DEFICIENCY*

1982 • 67 citations

Vitamin E and other endogenous antioxidants in the central nervous system.

1998 • 66 citations

Concentrations of α-tocopherol and its quinone derivative in cerebrospinal fluid from patients with vascular dementia of the Binswanger type and Alzheimer type dementia

1994 • 65 citations

Practice guideline for the treatment of patients with Alzheimer's disease and other dementias of late life. American Psychiatric Association [published erratum appears in Am J Psychiatry 1997 Aug;154(8):1180]

1997 • 64 citations

Effect of vitamin E intake on levels of vitamins E and C in the central nervous system and peripheral tissues: implications for health recommendations

1999 • 63 citations

The role of vitamin E in the nutrition of premature infants

1981 • 62 citations

Vitamin E concentrations in human brain of patients with Alzheimer's disease, fetuses with Down's syndrome, centenarians, and controls

1989 • 61 citations

Glutathione peroxidase in amyotrophic lateral sclerosis: the effects of selenium supplementation.

1998 • 58 citations

Vitamin E and Neurologic Deficits

1990 • 55 citations

Vitamin E and neurologic deficits.

1990 • 54 citations

A double-blind trial of vitamin E in angina pectoris1,2

1974 • 53 citations

Vitamin E for neuroleptic-induced tardive dyskinesia

2001 • 47 citations

Advanced glycation endproducts cause lipid peroxidation in the human neuronal cell line SH-SY5Y

2003 • 46 citations

Effects of vitamin E on ozone-induced memory deficits and lipid peroxidation in rats

1999 • 45 citations

Peripheral markers of oxidative stress in Parkinson’s disease. the role of L-DOPA

1999 • 45 citations

A double-blind trial of vitamin E in angina pectoris

1974 • 43 citations

Vitamin E (alpha-tocopherol) in the treatment of tardive dyskinesia: a statistical meta-analysis.

1998 • 42 citations

Vitamin E (α-Tocopherol) in the Treatment of Tardive Dyskinesia: A Statistical Meta-Analysis

1998 • 42 citations

Calcium channel blockers for neuroleptic-induced tardive dyskinesia

2000 • 40 citations

Free radicals and lipid peroxidation do not mediate β-amyloid-induced neuronal cell death

1999 • 38 citations

Oral Vitamin E Supplementation for the Prevention of Anemia in Premature Infants: A Controlled Trial

1987 • 36 citations

Effect of dietary vitamin E on lipofuscin accumulation with age in the rat brain

1994 • 36 citations

Treatment of Amyotrophic Lateral Sclerosis

1999 • 30 citations

Essential Fatty Acids in Alzheimer's Diseasea

1991 • 30 citations

Will antioxidants fulfill their expectations for the treatment of Alzheimer disease?

2000 • 28 citations

The effect of vitamin E addition to acute neuroleptic treatment on the emergence of extrapyramidal side effects in schizophrenic patients: An open label study

1999 • 26 citations

Pharmacological treatment of cognitive deficits in Alzheimer's disease

2001 • 24 citations

Vitamin E protects the brain against oxidative injury stimulated by excessive aluminum intake

1998 • 23 citations

Vitamin E in the Treatment of Tardive Dyskinesia

1999 • 18 citations

Comparison of the Clinical Courses in Patients with Juvenile Neuronal Ceroid Lipofuscinosis Receiving Antioxidant Treatment and Those without Antioxidant Treatment

1990 • 17 citations

The Role of Vitamin E Therapy in High-Risk Neonates

1988 • 14 citations

The coming of age of vitamin E

1989 • 13 citations

Antioxidant vitamins and cardiovascular disease: Dr Jekyll or Mr Hyde?

1999 • 11 citations

Lack of effect of vitamin E on serum creatine phosphokinase in patients with long-term tardive dyskinesia

1997 • 9 citations

Can vitamin supplements prevent cognitive decline and dementia in old age?

2003 • 8 citations

Vitamin E Treatment in Tardive Dystonia

1997 • 7 citations

Drugs for the prevention and treatment of Alzheimer's disease

1997 • 7 citations

Oestrogen shields brain from ageing

1999 • 6 citations

Antioxidants are useful in preventing cardiovascular disease: a debate. Pro antioxidants.

1999 • 3 citations

Gene study links iron with cardiovascular disease risk

1999 • 1 citations