Tocopherol-Associated Protein Suppresses Prostate Cancer Cell Growth by Inhibition of the Phosphoinositide 3-Kinase Pathway

The fundamental role of epigenetic events in cancer

2002 • 5,532 citations

The Phosphoinositide 3-Kinase Pathway

2002 • 5,427 citations

The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers

1994 • 4,626 citations

PI3K/Akt signalling pathway and cancer

2003 • 2,157 citations

Androgen Receptor in Prostate Cancer

2004 • 1,679 citations

Generation and characterization of androgen receptor knockout (ARKO) mice: An in vivo model for the study of androgen functions in selective tissues

2002 • 632 citations

Forkhead Transcription Factors Are Critical Effectors of Cell Death and Cell Cycle Arrest Downstream of PTEN

2000 • 569 citations

Role of PML in Cell Growth and the Retinoic Acid Pathway

1998 • 522 citations

Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor

2001 • 397 citations

Expression of estrogen receptor (ER)-alpha and ER-beta in normal and malignant prostatic epithelial cells: regulation by methylation and involvement in growth regulation.

2000 • 358 citations

Loss of the Tumor Suppressor PML in Human Cancers of Multiple Histologic Origins

2004 • 326 citations

Mutation of the gene encoding cellular retinaldehyde–binding protein in autosomal recessive retinitis pigmentosa

1997 • 323 citations

The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC–Cdc20 complex

2004 • 311 citations

The phosphatidylinositol 3'-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells.

1999 • 241 citations

Inhibition of constitutively activated Stat3 signaling pathway suppresses growth of prostate cancer cells.

2000 • 212 citations

Ligand Specificity in the CRAL-TRIO Protein Family

2003 • 194 citations

A Novel Human Tocopherol-associated Protein

2000 • 175 citations

The RASSF1A tumor suppressor gene is inactivated in prostate tumors and suppresses growth of prostate carcinoma cells.

2002 • 161 citations

Cancer genetics

2002 • 155 citations

Vitamin E succinate inhibits the function of androgen receptor and the expression of prostate-specific antigen in prostate cancer cells

2002 • 154 citations

Vitamin E Succinate Induces Apoptosis in Human Prostate Cancer Cells: Role for Fas in Vitamin E Succinate-Triggered Apoptosis

2000 • 148 citations

Antiapoptotic signaling in LNCaP prostate cancer cells: a survival signaling pathway independent of phosphatidylinositol 3'-kinase and Akt/protein kinase B.

1999 • 144 citations

Mutations in a novel gene encoding a CRAL-TRIO domain cause human Cayman ataxia and ataxia/dystonia in the jittery mouse

2003 • 144 citations

Developmental estrogenization and prostatic neoplasia

1994 • 137 citations

Vitamin E succinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery

2003 • 122 citations

Synergy between selenium and vitamin E in apoptosis induction is associated with activation of distinctive initiator caspases in human prostate cancer cells.

2003 • 117 citations

α-Tocopherol transfer protein stimulates the secretion of α-tocopherol from a cultured liver cell line through a brefeldin A-insensitive pathway

1997 • 117 citations

Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis

2001 • 106 citations

Differential Expression of Interleukin-8 and Its Receptors in the Neuroendocrine and Non-Neuroendocrine Compartments of Prostate Cancer

2005 • 104 citations

Tocopherol-Associated Protein Is a Ligand-Dependent Transcriptional Activator

2001 • 100 citations

Serun -Tecopherol Status in the United States Population: Findings from The Third National Health and Nutrition Examination Survey

1999 • 95 citations

Prognostic significance of Gleason pattern in patients with Gleason score 7 prostate carcinoma

2003 • 93 citations

Modulation of Cell Proliferation and Cell Cycle Regulators by Vitamin E in Human Prostate Carcinoma Cell Lines

2002 • 90 citations

Cloning of novel human SEC14p-like proteins: ligand binding and functional properties

2003 • 88 citations

Postmortem study of ataxia with retinitis pigmentosa by mutation of the alpha -tocopherol transfer protein gene

2000 • 88 citations

RRR‐α‐tocopheryl succinate inhibits the proliferation of human prostatic tumor cells with defective cell cycle/differentiation pathways

1995 • 86 citations

Expression of ERα and ERβ in prostate cancer

2003 • 84 citations

Vitamin E and other antioxidants inhibit human prostate cancer cells through apoptosis

2000 • 77 citations

Increased manganese superoxide dismutase (SOD-2) is part of the mechanism for prostate tumor suppression by Mac25/insulin-like growth factor binding-protein-related protein-1

2003 • 73 citations

RRR-α-tocopheryl succinate inhibits human prostate cancer cell invasiveness

2004 • 72 citations

Mammary carcinoma suppression by cellular retinoic acid binding protein-II.

2003 • 72 citations

Crystal Structure of the Human Supernatant Protein Factor

2002 • 66 citations

Mitogen Activated Protein kinase signal transduction pathways in the prostate.

2004 • 61 citations

Supernatant Protein Factor in Complex with RRR-α-Tocopherylquinone: A Link Between Oxidized Vitamin E and Cholesterol Biosynthesis

2003 • 56 citations

Adenovirus-mediated expression of PML suppresses growth and tumorigenicity of prostate cancer cells.

1997 • 51 citations

Stable expression of constitutively-activated STAT3 in benign prostatic epithelial cells changes their phenotype to that resembling malignant cells.

2005 • 50 citations

Regulation of interleukin‐6‐mediated PI3K activation and neuroendocrine differentiation by androgen signaling in prostate cancer LNCaP cells

2004 • 42 citations

α-tocopheryl succinate protects hepatocytes from chemical-induced toxicity under physiological calcium conditions

1989 • 33 citations

Update on hormone-refractory prostate cancer

2004 • 33 citations

Effect of vitamin E deficiency on the growth and secretory function of the rat prostatic complex

2003 • 31 citations

The α-tocopherol, β-carotene cancer prevention study

1997 • 29 citations

Modulation of Cell Proliferation and Cell Cycle Regulators by Vitamin E in Human Prostate Carcinoma Cell Lines

2002 • 18 citations

Tissue Microarrays

2004 • 10 citations