Peripheral antigen-expressing cells and autoimmunity

Regulatory T Cells

2000 • 1,827 citations

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

2001 • 1,043 citations

The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

1997 • 931 citations

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

1997 • 806 citations

Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus

1995 • 749 citations

A Polymorphic Locus Near the Human Insulin Gene Is Associated with Insulin-dependent Diabetes Melliitus

1984 • 744 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis.

1996 • 653 citations

Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells

2001 • 615 citations

Dendritic cells in the T‐cell areas of lymphoid organs

1997 • 572 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

Early expression of antiinsulin autoantibodies of humans and the NOD mouse: Evidence for early determination of subsequent diabetes

2000 • 456 citations

Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells

2000 • 399 citations

Development of CD8α-Positive Dendritic Cells from a Common Myeloid Progenitor

2000 • 398 citations

The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription

1995 • 383 citations

Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility

1991 • 378 citations

Generation of Functional Thymocytes in the Human Adult

1999 • 370 citations

The Roles of Costimulation and Fas in T Cell Apoptosis and Peripheral Tolerance

1996 • 367 citations

Molecular Cloning and Identification of a Receptor-Type Protein Tyrosine Phosphatase, IA-2, from Human Insulinoma

1994 • 317 citations

Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases.

1994 • 308 citations

Identification of a Thymic Epithelial Cell Subset Sharing Expression of the Class Ib HLA-G Molecule with Fetal Trophoblasts

1997 • 296 citations

Autoimmune Regulator Is Expressed in the Cells Regulating Immune Tolerance in Thymus Medulla

1999 • 293 citations

HUMAN TYPE 1 DIABETES AND THE INSULIN GENE: Principles of Mapping Polygenes

1996 • 291 citations

High Frequency of Autoreactive Myelin Proteolipid Protein–Specific T Cells in the Periphery of Naive Mice

2000 • 275 citations

Relationship of the 37,000- and 40,000-M(r) tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512).

1995 • 257 citations

ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules.

1996 • 251 citations

Transgenic Expression of Mouse Proinsulin II Prevents Diabetes in Nonobese Diabetic Mice

1997 • 248 citations

Definition of Dendritic Cell Subpopulations Present in the Spleen, Peyer’s Patches, Lymph Nodes, and Skin of the Mouse

1999 • 244 citations

Identification of protein tyrosine phosphatase-like IA2 (islet cell antigen 512) as the insulin-dependent diabetes-related 37/40K autoantigen and a target of islet-cell antibodies.

1995 • 239 citations

Acetylcholine receptors in human thymic myoid cells in situ: An immunohistological study

1987 • 226 citations

T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus.

1994 • 223 citations

T-Cell Epitopes in Type 1 Diabetes Autoantigen Tyrosine Phosphatase IA-2: Potential for Mimicry with Rotavirus and Other Environmental Agents

1998 • 213 citations

A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin

2001 • 210 citations

A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus

1984 • 205 citations

Intrathymic and extrathymic clonal deletion of T cells

1995 • 201 citations

Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis.

1996 • 196 citations

Endogenous Myelin Basic Protein Inactivates the High Avidity T Cell Repertoire

1998 • 188 citations

Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity

1998 • 188 citations

Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance

1997 • 183 citations

The Neuroendocrine Thymus: Coexistence of Oxytocin and Neurophysin in the Human Thymus

1986 • 183 citations

Differential Tolerance Is Induced in T Cells Recognizing Distinct Epitopes of Myelin Basic Protein

1998 • 182 citations

Transcription of a Broad Range of Self-Antigens in Human Thymus Suggests a Role for Central Mechanisms in Tolerance Toward Peripheral Antigens

1998 • 173 citations

Self-antigen–presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs

2001 • 171 citations

IDDM2-VNTR-encoded Susceptibility to Type 1 Diabetes: Dominant Protection and Parental Transmission of Alleles of the Insulin Gene-linked Minisatellite Locus

1996 • 165 citations

Thymic dendritic cells

1997 • 163 citations

Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4

1999 • 159 citations

Intrathymic Expression of Genes Involved in Organ Specific Autoimmune Disease

1998 • 155 citations

Role of CD8α+ and CD8α− dendritic cells in the induction of primary immune responses in vivo

1999 • 151 citations

Expression of acetylcholine receptor genes in human thymic epithelial cells: implications for myasthenia gravis.

1996 • 139 citations

Autoreactive T cell Responses in Insulin-dependent (Type 1) Diabetes Mellitus. Report of the First International Workshop for Standardization of T cell assays

1999 • 130 citations

Intrathymic presentation of circulating non-MHC antigens by medullary dendritic cells. An antigen-dependent microenvironment for T cell differentiation.

1986 • 126 citations

Promiscuous expression of tissue antigens in the thymus: a key to T-cell tolerance and autoimmunity?

2000 • 117 citations

Evidence That a Peptide Spanning the B-C Junction of Proinsulin Is an Early Autoantigen Epitope in the Pathogenesis of Type 1 Diabetes

2001 • 116 citations

Differential Splicing of the IA-2 mRNA in Pancreas and Lymphoid Organs as a Permissive Genetic Mechanism for Autoimmunity Against the IA-2 Type 1 Diabetes Autoantigen

2001 • 102 citations

Somatostatin gene expression in the thymus gland.

1989 • 95 citations

Cellular and peptide requirements for in vitro clonal deletion of immature thymocytes.

1992 • 90 citations

The uniqueness of the imprinting mechanism

2000 • 83 citations

Involvement of Insulin-Like Growth Factors in Early T Cell Development: A Study Using Fetal Thymic Organ Cultures¹

2000 • 79 citations

Pancreatic Hormone Expression in the Murine Thymus: Localization in Dendritic Cells and Macrophages

1998 • 78 citations

Evidence that insulin-like growth factor 2 (IGF2) is the dominant thymic peptide of the insulin superfamily.

1993 • 76 citations

Characterization of Insulin Autoantibodies in Relatives of Patients With Type I Diabetes

1993 • 74 citations

T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes.

2000 • 74 citations

Evidence of IgG Autoantibodies Against Human Proinsulin in Patients With IDDM Before Insulin Treatment

1988 • 73 citations

Thymic nurse cells are sites of thymocyte apoptosis.

1994 • 66 citations

Molecular evidence for the expression of nicotinic acetylcholine receptor alpha-chain in mouse thymus.

1992 • 60 citations

Escape of Thymocytes and Mature T Cells from Clonal Deletion Due to Limiting Tolerogen Expression Levels

1994 • 57 citations

T-cell tolerance

1993 • 55 citations

Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice

1997 • 55 citations

Proteins with epitopes of the acetylcholine receptor in epithelial cell cultures of thymomas in myasthenia gravis.

1989 • 50 citations

It's Insulin

2000 • 49 citations

Colocalization of immunoreactive oxytocin, vasopressin and interleukin-1 in human thymic epithelial neuroendocrine cells

1991 • 49 citations

An acetylcholine receptor alpha subunit promoter confers intrathymic expression in transgenic mice. Implications for tolerance of a transgenic self-antigen and for autoreactivity in myasthenia gravis.

1998 • 49 citations

Thymic expression of insulin-related genes in an animal model of autoimmune type 1 diabetes

2001 • 46 citations

The Paternally Inherited Insulin Gene B Allele (1,428 FokI site) Confers Protection from Insulin-dependent Diabetes in Families

1994 • 41 citations

Evidence of IgG autoantibodies against human proinsulin in patients with IDDM before insulin treatment

1988 • 41 citations

Aberrant Expression of Tissue‐Specific Proteins in the Thymus: A Hypothesis for the Development of Central Tolerance

1998 • 39 citations

Mice resistant to experimental autoimmune encephalomyelitis have increased thymic expression of myelin basic protein and increased MBP specific T cell tolerance

2001 • 38 citations

Parental imprinting effect at the INS-IGF2 diabetes susceptibility locus

1995 • 37 citations

Neoplastic epithelial cells express α‐subunit of muscle nicotinic acetylcholine receptor in thymomas from patients with myasthenia gravis

1991 • 36 citations

Characterization of the Insulin‐Like Growth Factor Axis in the Human Thymus

1999 • 35 citations

Pancreatic Hormone Expression in the Murine Thymus: Localization in Dendritic Cells and Macrophages

1998 • 29 citations

Humoral autoreactivity to an alternatively spliced variant of ICA512/IA-2 in Type I diabetes

2000 • 29 citations

Characterization of insulin autoantibodies in relatives of patients with type I diabetes

1993 • 26 citations

Paternally TransmittedIDDM2Influences Diabetes Susceptibility Despite Biallelic Expression of the Insulin Gene in Human Pancreas

1996 • 25 citations

The intrathymic expression of insulin-related genes: implications for pathophysiology and prevention of Type 1 diabetes

1998 • 25 citations

Involvement of Insulin-Like Growth Factors in Early T Cell Development: A Study Using Fetal Thymic Organ Cultures

2000 • 21 citations

Autoantibodies to Insulin and to Proinsulin in Type 1 Diabetic Patients and in At-Risk Probands Differentiate Only Little between Both Antigens

1995 • 20 citations

Natural and induced apoptosis during lymphocyte development in the axolotl

1999 • 18 citations

T-cell mediated autoimmunity to the insulinoma-associated protein 2 islet tyrosine phosphatase in type 1 diabetes mellitus

1999 • 16 citations

Thymic Neuroendocrine Self‐Antigens: Role in T‐Cell Development and Central T‐Cell Self‐Tolerance

2000 • 13 citations

Proliferative responses to selected peptides of IA-2 in identical twins discordant for Type 1 diabetes

2000 • 7 citations

Thymic neuroendocrine self-antigens. Role in T-cell development and central T-cell self-tolerance

1999 • 7 citations

Deleted Work

1955 • 0 citations