Thymic expression of insulin-related genes in an animal model of autoimmune type 1 diabetes

The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

1997 • 931 citations

Insulin-Dependent Diabetes Mellitus as an Autoimmune Disease

1994 • 818 citations

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

1997 • 806 citations

Somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues.

1986 • 531 citations

Measurement of serum ferritin by a 2-site immunoradiometric assay

1974 • 502 citations

Developmental regulation of insulin-like growth factor II mRNA in different rat tissues.

1986 • 322 citations

Expression of the insulin-like growth factor II gene in the choroid plexus and the leptomeninges of the adult rat central nervous system.

1988 • 262 citations

Oral insulin administration and residual (β-cell function in recent-onset type 1 diabetes: a multicentre randomised controlled trial

2000 • 239 citations

Autoimmune diabetes mellitus in the BB rat

1992 • 223 citations

T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus.

1994 • 223 citations

No effect of oral insulin on residual beta-cell function in recent-onset Type I diabetes (the IMDIAB VII)

2000 • 211 citations

Rat insulin-like growth factor II gene

1986 • 192 citations

IDDM2-VNTR-encoded Susceptibility to Type 1 Diabetes: Dominant Protection and Parental Transmission of Alleles of the Insulin Gene-linked Minisatellite Locus

1996 • 165 citations

Tissue-Specific and Developmentally Regulated Transcription of the Insulin-Like Growth Factor 2 Gene

1987 • 161 citations

Intrathymic Expression of Genes Involved in Organ Specific Autoimmune Disease

1998 • 155 citations

Developmental and tissue-specific expression of a family of transcripts related to rat insulin-like growth factor II mRNA

1985 • 155 citations

The INS 5′ Variable Number of Tandem Repeats Is Associated with IGF2 Expression in Humans

1998 • 141 citations

Structure and expression of the rat insulin-like growth factor II (rIGF-II) gene. rIGF-II RNAs are transcribed from two promoters.

1986 • 122 citations

Insulin-Like Growth Factor Gene Expression during Rat Embryonic Development*

1987 • 118 citations

Thymus epithelium induces tissue-specific tolerance.

1993 • 111 citations

Murine macrophages express abundant insulin-like growth factor-I class I Ea and Eb transcripts.

1993 • 105 citations

Similar peptides from two beta cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes.

1995 • 103 citations

Analysis of the Spontaneous T Cell Response to Insulin in NOD Mice

1994 • 101 citations

Preproinsulin I and II mRNAs and insulin electron microscopic immunoreaction are present within the rat fetal nervous system

1996 • 92 citations

Similar Peptides from Two β Cell Autoantigens, Proinsulin and Glutamic Acid Decarboxylase, Stimulate T Cells of Individuals at Risk for Insulin-Dependent Diabetes

1995 • 86 citations

Involvement of Insulin-Like Growth Factors in Early T Cell Development: A Study Using Fetal Thymic Organ Cultures¹

2000 • 79 citations

Pancreatic Hormone Expression in the Murine Thymus: Localization in Dendritic Cells and Macrophages

1998 • 78 citations

Coordinate developmental regulation of high and low molecular weight mRNAs for rat insulin-like growth factor II.

1986 • 77 citations

Evidence that insulin-like growth factor 2 (IGF2) is the dominant thymic peptide of the insulin superfamily.

1993 • 76 citations

The thymic repertoire of neuroendocrine self-antigens: physiological implications in T-cell life and death

1996 • 70 citations

Central Tolerance of T Cells

1995 • 61 citations

The BB/Wor Rat and the Balance Hypothesis of Autoimmunity

1996 • 59 citations

Pulsatile Secretion of Gonadotropin-Releasing Hormone by Rat Hypothalamic Explants of GnRH Neurons without Cell Bodies

1997 • 58 citations

The BB/Wor Rat and the Balance Hypothesis of Autoimmunity

1996 • 57 citations

Non-major histocompatibility complex-linked diabetes susceptibility loci on chromosomes 4 and 13 in a backcross of the DP-BB/Wor rat to the WF rat.

1999 • 50 citations

Diabetes-prone and diabetes-resistant BB rats share a common major diabetes susceptibility locus, iddm4: additional evidence for a "universal autoimmunity locus" on rat chromosome 4.

1999 • 48 citations

Divergence between Genetic Determinants ofIGF2Transcription Levels in Leukocytes and ofIDDM2-Encoded Susceptibility to Type 1 Diabetes¹

1998 • 40 citations

Characterization of the Insulin‐Like Growth Factor Axis in the Human Thymus

1999 • 35 citations

Mapping of Novel Genes Predisposing or Protecting Diabetes Development in the BB/OK Rat

1998 • 32 citations

Thymic epithelial defects and predisposition to autoimmune disease in BB rats.

1994 • 32 citations

Experimental autoimmune insulitis. Induction by T lymphocytes specific for a peptide of proinsulin.

1995 • 31 citations

Review Article Thymic Expression of Neuroendocrine Self‐Peptide Precursors: Role in T Cell Survival and Self‐Tolerance

1998 • 26 citations

The intrathymic expression of insulin-related genes: implications for pathophysiology and prevention of Type 1 diabetes

1998 • 25 citations

Expression of insulin-like growth factor II (IGF-II) and histological changes in the thymus and spleen of transgenic mice overexpressing IGF-II

1997 • 22 citations

Recapitulation of Normal and Abnormal BioBreeding Rat T Cell Development in Adult Thymus Organ Culture

1999 • 20 citations

The lymphopenia (lyp ) gene controls the intrathymic cytokine ratio in congenic BioBreeding rats

1997 • 18 citations

Processing and presentation of insulin. III. Insulin degrading enzyme: a neutral metalloendoproteinase that is non-homologous to classical endoproteinases mediates the processing of insulin epitopes for helper T cells

1992 • 12 citations

No effect of oral insulin on residual beta-cell function in recent onset type 1 diabetes

2000 • 5 citations

Deleted Work

1955 • 0 citations

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