Vascular Permeability and Pathological Angiogenesis in Caveolin-1-Null Mice

STUDIES ON INFLAMMATION

1961 • 1,539 citations

Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice

2001 • 1,517 citations

Caveolin-1 Null Mice Are Viable but Show Evidence of Hyperproliferative and Vascular Abnormalities

2001 • 1,144 citations

Role of Caveolae and Caveolins in Health and Disease

2004 • 882 citations

ENDOTHELIAL CONTRACTION INDUCED BY HISTAMINE-TYPE MEDIATORS

1969 • 841 citations

Molecular Cloning of Caveolin-3, a Novel Member of the Caveolin Gene Family Expressed Predominantly in Muscle

1996 • 737 citations

Vascular permeability, vascular hyperpermeability and angiogenesis

2008 • 577 citations

Vascular endothelial growth factor C induces angiogenesis in vivo

1998 • 558 citations

eNOS at a glance

2004 • 547 citations

Transport of macromolecules across microvascular walls: the two-pore theory

1994 • 537 citations

STUDIES ON BLOOD CAPILLARIES

1968 • 449 citations

STRUCTURAL MODULATIONS OF PLASMALEMMAL VESICLES

1968 • 427 citations

Heterogeneity of the Angiogenic Response Induced in Different Normal Adult Tissues by Vascular Permeability Factor/Vascular Endothelial Growth Factor

2000 • 421 citations

VEGF-A and the Induction of Pathological Angiogenesis

2007 • 400 citations

The Caveolin genes: from cell biology to medicine

2004 • 368 citations

Caveolin, Caveolae, and Endothelial Cell Function

2003 • 363 citations

Microvascular Hyperpermeability in Caveolin-1 (−/−) Knock-out Mice

2002 • 311 citations

Caveolae and Caveolins in the Cardiovascular System

2004 • 310 citations

Vesiculo-vacuolar organelles and the regulation of venule permeability to macromolecules by vascular permeability factor, histamine, and serotonin.

1996 • 280 citations

Cellular aspects of transcapillary exchange

1983 • 277 citations

Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis

2007 • 276 citations

The Vesiculo–Vacuolar Organelle (VVO): A New Endothelial Cell Permeability Organelle

2001 • 271 citations

The vesiculo-vacuolar organelle (VVO): a distinct endothelial cell structure that provides a transcellular pathway for macromolecular extravasation

1996 • 266 citations

Caveolae: mining little caves for new cancer targets

2003 • 260 citations

Caveolin-1 Expression Is Critical for Vascular Endothelial Growth Factor–Induced Ischemic Hindlimb Collateralization and Nitric Oxide–Mediated Angiogenesis

2004 • 224 citations

Caveolin-1/3 Double-Knockout Mice Are Viable, but Lack Both Muscle and Non-Muscle Caveolae, and Develop a Severe Cardiomyopathic Phenotype

2002 • 204 citations

Pathways of macromolecular tracer transport across venules and small veins. Structural basis for the hyperpermeability of tumor blood vessels.

1992 • 191 citations

Vascular Endothelial Growth Factor-A Promotes Peritumoral Lymphangiogenesis and Lymphatic Metastasis

2005 • 182 citations

Pathways of Macromolecular Extravasation Across Microvascular Endothelium in Response to VPF/VEGF and Other Vasoactive Mediators

1999 • 180 citations

Angiogenesis Activators and Inhibitors Differentially Regulate Caveolin-1 Expression and Caveolae Formation in Vascular Endothelial Cells

1999 • 163 citations

Caveolins and the regulation of endothelial nitric oxide synthase in the heart

2006 • 159 citations

Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis

2004 • 158 citations

Orphan nuclear receptor TR3/Nur77 regulates VEGF-A–induced angiogenesis through its transcriptional activity

2006 • 155 citations

VEGF-induced permeability increase is mediated by caveolae.

1999 • 154 citations

A role for caveolae in cell migration

2004 • 152 citations

Role of caveolin-1 in the regulation of lipoprotein metabolism

2008 • 148 citations

Caveolin-1–Deficient Mice Have Increased Tumor Microvascular Permeability, Angiogenesis, and Growth

2007 • 147 citations

Endothelial gaps: time course of formation and closure in inflamed venules of rats

1997 • 145 citations

Caveolae and transcytosis in endothelial cells: role in atherosclerosis

2008 • 141 citations

Caveolin-1 Knockout Mice Show an Impaired Angiogenic Response to Exogenous Stimuli

2003 • 131 citations

Endothelial stomatal and fenestral diaphragms in normal vessels and angiogenesis

2007 • 124 citations

Caveolin-1 Deficiency Increases Cerebral Ischemic Injury

2007 • 124 citations

Reinterpretation of endothelial cell gaps induced by vasoactive mediators in guinea‐fig, mouse and rat: many are transcellular pores

1997 • 120 citations

Ultrastructural Localization of the Vascular Permeability Factor/Vascular Endothelial Growth Factor (VPF/VEGF) Receptor-2 (FLK-1, KDR) in Normal Mouse Kidney and in the Hyperpermeable Vessels Induced by VPF/VEGF-expressing Tumors and Adenoviral Vectors

2000 • 119 citations

Permeability properties of tumor surrogate blood vessels induced by VEGF-A

2006 • 109 citations

Different Pathways of Macromolecule Extravasation from Hyperpermeable Tumor Vessels

2000 • 100 citations

Caveolin-1-Deficient Mice Show Defects in Innate Immunity and Inflammatory Immune Response during Salmonella enterica Serovar Typhimurium Infection

2006 • 92 citations

Caveolin-1 and caveolae in atherosclerosis: differential roles in fatty streak formation and neointimal hyperplasia

2004 • 89 citations

Knockdown of Caveolin-1 by Antisense Oligonucleotides Impairs Angiogenesis in Vitro and in Vivo

2000 • 87 citations

Openings Through Endothelial Cells Associated with Increased Microvascular Permeability

1999 • 79 citations

Caveolin-1(−/−)- and Caveolin-2(−/−)-Deficient Mice Both Display Numerous Skeletal Muscle Abnormalities, with Tubular Aggregate Formation

2007 • 69 citations

Procedural guide to specimen handling for the ultrastructural pathology service laboratory

1987 • 67 citations

Transvascular protein transport in mice lacking endothelial caveolae

2006 • 63 citations

Ultrastructural Localization of Platelet Endothelial Cell Adhesion Molecule (PECAM-1, CD31) in Vascular Endothelium

2004 • 63 citations

Antitumor effects of in vivo caveolin gene delivery are associated with the inhibition of the proangiogenic and vasodilatory effects of nitric oxide

2004 • 47 citations

Caveolin-1 Is Critical for the Maturation of Tumor Blood Vessels through the Regulation of Both Endothelial Tube Formation and Mural Cell Recruitment

2007 • 46 citations

Openings Through Endothelial Cells Associated with Increased Microvascular Permeability

1999 • 44 citations

Expression of caveolin‐1 in lymphocytes induces caveolae formation and recruitment of phosphofructokinase to the plasma membrane

2005 • 26 citations

Chapter 3 The Adenoviral Vector Angiogenesis/Lymphangiogenesis Assay

2008 • 22 citations

Electron Microscopic–Facilitated Understanding of Endothelial Cell Biology: Contributions Established during the 1950s and 1960s

2007 • 3 citations