The Caveolin genes: from cell biology to medicine

Lipid rafts and signal transduction

2000 • 6,079 citations

FUNCTIONS OF LIPID RAFTS IN BIOLOGICAL MEMBRANES

1998 • 2,942 citations

Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice

2001 • 1,517 citations

Caveolin-1 Null Mice Are Viable but Show Evidence of Hyperproliferative and Vascular Abnormalities

2001 • 1,144 citations

Caveolae: From Cell Biology to Animal Physiology

2002 • 977 citations

Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells

1993 • 961 citations

Identification of Peptide and Protein Ligands for the Caveolin-scaffolding Domain

1997 • 909 citations

VIP21/caveolin is a cholesterol-binding protein.

1995 • 892 citations

Dissecting the Interaction between Nitric Oxide Synthase (NOS) and Caveolin

1997 • 808 citations

Src Tyrosine Kinases, Gα Subunits, and H-Ras Share a Common Membrane-anchored Scaffolding Protein, Caveolin

1996 • 770 citations

Dynamin-mediated Internalization of Caveolae

1998 • 750 citations

Molecular Cloning of Caveolin-3, a Novel Member of the Caveolin Gene Family Expressed Predominantly in Muscle

1996 • 737 citations

Expression of Caveolin-3 in Skeletal, Cardiac, and Smooth Muscle Cells

1996 • 692 citations

Dynamin at the Neck of Caveolae Mediates Their Budding to Form Transport Vesicles by GTP-driven Fission from the Plasma Membrane of Endothelium

1998 • 657 citations

Direct Interaction of Endothelial Nitric-oxide Synthase and Caveolin-1 Inhibits Synthase Activity

1997 • 647 citations

Caveolae, caveolin and caveolin-rich membrane domains: a signalling hypothesis

1994 • 646 citations

Caveolin-1 Regulates Transforming Growth Factor (TGF)-β/SMAD Signaling through an Interaction with the TGF-β Type I Receptor

2001 • 638 citations

Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion

2003 • 631 citations

Reciprocal Regulation of Endothelial Nitric-oxide Synthase by Ca2+-Calmodulin and Caveolin

1997 • 610 citations

Mutations in the caveolin-3 gene cause autosomal dominant limb-girdle muscular dystrophy

1998 • 590 citations

Multiple Functions of Caveolin-1

2002 • 579 citations

Emerging Themes in Lipid Rafts and Caveolae

2001 • 567 citations

Identification, sequence, and expression of caveolin-2 defines a caveolin gene family.

1996 • 566 citations

Caveolin-1-deficient Mice Are Lean, Resistant to Diet-induced Obesity, and Show Hypertriglyceridemia with Adipocyte Abnormalities

2002 • 557 citations

VIP21, a 21-kD membrane protein is an integral component of trans-Golgi-network-derived transport vesicles.

1992 • 544 citations

Cell-type and Tissue-specific Expression of Caveolin-2

1997 • 524 citations

Reduction of caveolin and caveolae in oncogenically transformed cells.

1995 • 505 citations

A Role for Caveolin in Transport of Cholesterol from Endoplasmic Reticulum to Plasma Membrane

1996 • 496 citations

Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade

1998 • 473 citations

Caveolin-3 Null Mice Show a Loss of Caveolae, Changes in the Microdomain Distribution of the Dystrophin-Glycoprotein Complex, and T-tubule Abnormalities

2001 • 450 citations

Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells

1998 • 435 citations

Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice

2002 • 434 citations

Induction of caveolin during adipogenesis and association of GLUT4 with caveolin-rich vesicles.

1994 • 413 citations

Recombinant Expression of Caveolin-1 in Oncogenically Transformed Cells Abrogates Anchorage-independent Growth

1997 • 377 citations

Murine SR-BI, a High Density Lipoprotein Receptor That Mediates Selective Lipid Uptake, Is N-Glycosylated and Fatty Acylated and Colocalizes with Plasma Membrane Caveolae

1997 • 375 citations

Caveolin‐mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo

1998 • 371 citations

Endothelial Caveolae Have the Molecular Transport Machinery for Vesicle Budding, Docking, and Fusion Including VAMP, NSF, SNAP, Annexins, and GTPases

1995 • 370 citations

Sequence and expression of caveolin, a protein component of caveolae plasma membrane domains phosphorylated on tyrosine in Rous sarcoma virus-transformed fibroblasts.

1992 • 369 citations

Localization of the insulin receptor in caveolae of adipocyte plasma membrane

1999 • 364 citations

Tyrosine Phosphorylation of a 22-kDa Protein Is Correlated with Transformation by Rous Sarcoma Virus

1989 • 363 citations

Caveolin Isoforms Differ in Their N-terminal Protein Sequence and Subcellular Distribution. IDENTIFICATION AND EPITOPE MAPPING OF AN ISOFORM-SPECIFIC MONOCLONAL ANTIBODY PROBE

1995 • 362 citations

Purification and characterization of smooth muscle cell caveolae.

1994 • 347 citations

Caveolin-1-deficient mice show insulin resistance and defective insulin receptor protein expression in adipose tissue

2003 • 344 citations

Cholesterol Depletion Disrupts Caveolae and Insulin Receptor Signaling for Metabolic Control via Insulin Receptor Substrate-1, but Not for Mitogen-activated Protein Kinase Control

2001 • 339 citations

Caveolae-deficient Endothelial Cells Show Defects in the Uptake and Transport of Albumin in Vivo

2001 • 325 citations

Caveolin-2-Deficient Mice Show Evidence of Severe Pulmonary Dysfunction without Disruption of Caveolae

2002 • 318 citations

Microvascular Hyperpermeability in Caveolin-1 (−/−) Knock-out Mice

2002 • 311 citations

Role of Caveolin-1 in the Modulation of Lipolysis and Lipid Droplet Formation

2004 • 303 citations

Caveolin Is an Activator of Insulin Receptor Signaling

1998 • 297 citations

Caveolin-3 Knock-out Mice Develop a Progressive Cardiomyopathy and Show Hyperactivation of the p42/44 MAPK Cascade

2002 • 283 citations

Caveolin-1 inhibits anchorage-independent growth, anoikis and invasiveness in MCF-7 human breast cancer cells

2002 • 267 citations

Caveolin-1 Expression Negatively Regulates Cell Cycle Progression by Inducing G₀/G₁Arrest via a p53/p21^WAF1/Cip1-dependent Mechanism

2001 • 267 citations

Two sterol regulatory element-like sequences mediate up-regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol

1997 • 256 citations

M‐caveolin, a muscle‐specific caveolin‐related protein

1996 • 238 citations

Caveolin-3 in muscular dystrophy

1998 • 230 citations

Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts

2003 • 229 citations

Genes encoding human caveolin‐1 and ‐2 are co‐localized to the D7S522 locus (7q31.1), a known fragile site (FRA7G) that is frequently deleted in human cancers

1998 • 227 citations

Up-regulation of Caveolin Attenuates Epidermal Growth Factor Signaling in Senescent Cells

2000 • 226 citations

Invasion activating caveolin-1 mutation in human scirrhous breast cancers.

2001 • 225 citations

The sequence of human caveolin reveals identity with VIP21, a component of transport vesicles

1992 • 223 citations

Expression and Characterization of Recombinant Caveolin

1996 • 223 citations

Expression of Caveolin-1 Is Required for the Transport of Caveolin-2 to the Plasma Membrane

1999 • 205 citations

Mutations in CAV3 cause mechanical hyperirritability of skeletal muscle in rippling muscle disease

2001 • 205 citations

Caveolin-1/3 Double-Knockout Mice Are Viable, but Lack Both Muscle and Non-Muscle Caveolae, and Develop a Severe Cardiomyopathic Phenotype

2002 • 204 citations

Caveolin-3 Directly Interacts with the C-terminal Tail of β-Dystroglycan

2000 • 202 citations

M‐caveolin, a muscle‐specific caveolin‐related protein

1995 • 188 citations

Caveolin-1 Interacts with the Insulin Receptor and Can Differentially Modulate Insulin Signaling in Transfected Cos-7 Cells and Rat Adipose Cells

1999 • 188 citations

Caveolin-1 Mutations (P132L and Null) and the Pathogenesis of Breast Cancer

2002 • 188 citations

Caveolinopathies

2004 • 184 citations

Caveolin-3 deficiency causes muscle degeneration in mice

2000 • 168 citations

p42/44 MAP Kinase-dependent and -independent Signaling Pathways Regulate Caveolin-1 Gene Expression

1999 • 167 citations

Caveolin-1 Expression Enhances Endothelial Capillary Tubule Formation

2002 • 166 citations

Phenotypic Behavior of Caveolin-3 Mutations That Cause Autosomal Dominant Limb Girdle Muscular Dystrophy (LGMD-1C)

1999 • 158 citations

Mutation in the CAV3 gene causes partial caveolin-3 deficiency and persistent elevated levels of serum creatine kinase

2000 • 157 citations

Lipid rafts are required for GLUT4 internalization in adipose cells

2001 • 155 citations

Transgenic overexpression of caveolin-3 in skeletal muscle fibers induces a Duchenne-like muscular dystrophy phenotype

2000 • 154 citations

Identification and functional analysis of a caveolin-3 mutation associated with familial hypertrophic cardiomyopathy

2003 • 152 citations

Caveolin-1 Null (−/−) Mice Show Dramatic Reductions in Life Span

2003 • 150 citations

The Cyclin D1 Gene Is Transcriptionally Repressed by Caveolin-1

2000 • 145 citations

Loss of Caveolin-1 Gene Expression Accelerates the Development of Dysplastic Mammary Lesions in Tumor-Prone Transgenic Mice

2003 • 143 citations

Caveolin-1 Knockout Mice Show an Impaired Angiogenic Response to Exogenous Stimuli

2003 • 131 citations

[47] Caveolae purification and glycosylphosphatidylinositol-linked protein sorting in polarized epithelia

1995 • 123 citations

The Insulin Receptor Catalyzes the Tyrosine Phosphorylation of Caveolin-1

2002 • 123 citations

Alterations in Membrane Cholesterol That Affect Structure and Function of Caveolae

2002 • 123 citations

The Adipocyte Plasma Membrane Caveolin Functional/Structural Organization Is Necessary for the Efficient Endocytosis of GLUT4

2003 • 119 citations

Caveolin-I, a putative tumour suppressor gene

2001 • 118 citations

Caveolin and its cellular and subcellular immunolocalisation in lung alveolar epithelium: implications for alveolar epithelial type I cell function

1999 • 114 citations

Caveolae and intracellular trafficking of cholesterol

2001 • 113 citations

Involvement of caveolin-1 in meiotic cell-cycle progression in Caenorhabditis elegans

1999 • 110 citations

Identification and functional analysis of a caveolin-3 mutation associated with familial hypertrophic cardiomyopathy

2004 • 104 citations

Increased Number of Caveolae and Caveolin-3 Overexpression in Duchenne Muscular Dystrophy

1999 • 103 citations

Insulin-Stimulated Glucose Uptake Involves the Transition of Glucose Transporters to a Caveolae-Rich Fraction within the Plasma Membrane: Implications for Type II Diabetes

1996 • 102 citations

Limb-girdle Muscular Dystrophy (LGMD-1C) Mutants of Caveolin-3 Undergo Ubiquitination and Proteasomal Degradation

2000 • 97 citations

Insulin induces translocation of glucose transporter GLUT4 to plasma membrane caveolae in adipocytes

2001 • 96 citations

Disruption of the Caveolin-1 Gene Impairs Renal Calcium Reabsorption and Leads to Hypercalciuria and Urolithiasis

2003 • 93 citations

Caveolin-1 and caveolin-2,together with three bone morphogenetic protein-related genes, may encode novel tumor suppressors down-regulated in sporadic follicular thyroid carcinogenesis.

2003 • 87 citations

Transgenic mice expressing mutant caveolin-3 show severe myopathy associated with increased nNOS activity

2001 • 86 citations

Increased caveolin‐3 levels in mdx mouse muscles

1998 • 83 citations

Homozygous mutations in caveolin‐3 cause a severe form of rippling muscle disease

2003 • 81 citations

Urogenital Alterations in Aged Male Caveolin-1 Knockout Mice

2004 • 76 citations

Combined Loss of INK4a and Caveolin-1 Synergistically Enhances Cell Proliferation and Oncogene-induced Tumorigenesis

2004 • 74 citations

Transgenic overexpression of caveolin-3 in the heart induces a cardiomyopathic phenotype

2003 • 64 citations

A caveolin-3 mutant that causes limb girdle muscular dystrophy type 1C disrupts Src localization and activity and induces apoptosis in skeletal myotubes

2003 • 58 citations

Insulin-Induced Protein Tyrosine Phosphorylation Cascade and Signalling Molecules Are Localized in a Caveolin-Enriched Cell Membrane Domain

1998 • 53 citations

Mutation and aberrant expression of Caveolin-1 in human oral squamous cell carcinomas and oral cancer cell lines

2004 • 47 citations

Purification of Caveolae-Derived Membrane Microdomains Containing Lipid-Anchored Signaling Molecules, Such as GPI-Anchored Proteins, H-Ras, Src-Family Tyrosine Kinases, eNOS, and G-Protein α-, β-, and γ-Subunits

2003 • 35 citations

Phosphofructokinase Muscle-Specific Isoform Requires Caveolin-3 Expression for Plasma Membrane Recruitment and Caveolar Targeting

2003 • 29 citations