Caveolin-1 and caveolae in atherosclerosis: differential roles in fatty streak formation and neointimal hyperplasia

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

1989 • 2,183 citations

The Response-to-Retention Hypothesis of Early Atherogenesis

1995 • 1,365 citations

A major role for VCAM-1, but not ICAM-1, in early atherosclerosis

2001 • 1,153 citations

Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human disease.

1994 • 912 citations

Acylation Targets Endothelial Nitric-oxide Synthase to Plasmalemmal Caveolae

1996 • 798 citations

High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase

2001 • 712 citations

Transcytosis: Crossing Cellular Barriers

2003 • 629 citations

Reciprocal Regulation of Endothelial Nitric-oxide Synthase by Ca2+-Calmodulin and Caveolin

1997 • 610 citations

Caveolin-1-deficient Mice Are Lean, Resistant to Diet-induced Obesity, and Show Hypertriglyceridemia with Adipocyte Abnormalities

2002 • 557 citations

Endothelial Nitric Oxide Synthase Is Regulated by Tyrosine Phosphorylation and Interacts with Caveolin-1

1996 • 532 citations

Cell-type and Tissue-specific Expression of Caveolin-2

1997 • 524 citations

A Role for Caveolin in Transport of Cholesterol from Endoplasmic Reticulum to Plasma Membrane

1996 • 496 citations

Atherosclerosis in the Apolipoprotein E–Deficient Mouse

2004 • 472 citations

Hydroxy-Methylglutaryl–Coenzyme A Reductase Inhibition Promotes Endothelial Nitric Oxide Synthase Activation Through a Decrease in Caveolin Abundance

2001 • 418 citations

Nitric Oxide Reversibly Inhibits the Migration of Cultured Vascular Smooth Muscle Cells

1996 • 412 citations

A Role for p38MAPK/HSP27 Pathway in Smooth Muscle Cell Migration

1999 • 401 citations

Hypercholesterolemia decreases nitric oxide production by promoting the interaction of caveolin and endothelial nitric oxide synthase

1999 • 396 citations

Caveolin‐mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo

1998 • 371 citations

Caveolin, Caveolae, and Endothelial Cell Function

2003 • 363 citations

Localization of Apoptotic Macrophages at the Site of Plaque Rupture in Sudden Coronary Death

2000 • 360 citations

Oxidized Low Density Lipoprotein Displaces Endothelial Nitric-oxide Synthase (eNOS) from Plasmalemmal Caveolae and Impairs eNOS Activation

1999 • 357 citations

Purification and characterization of smooth muscle cell caveolae.

1994 • 347 citations

Adhesion molecules and atherogenesis

2001 • 330 citations

Caveolae-deficient Endothelial Cells Show Defects in the Uptake and Transport of Albumin in Vivo

2001 • 325 citations

Involvement of Cellular Caveolae in Bacterial Entry into Mast Cells

2000 • 317 citations

Microvascular Hyperpermeability in Caveolin-1 (−/−) Knock-out Mice

2002 • 311 citations

High Density Lipoprotein Prevents Oxidized Low Density Lipoprotein-induced Inhibition of Endothelial Nitric-oxide Synthase Localization and Activation in Caveolae

2000 • 308 citations

Regulation of caveolin and caveolae by cholesterol in MDCK cells

1998 • 307 citations

Survival of FimH-expressing enterobacteria in macrophages relies on glycolipid traffic

1997 • 303 citations

Plasma membrane caveolae mediate the efflux of cellular free cholesterol

1995 • 273 citations

Initiation of atherosclerotic lesions in cholesterol-fed rabbits. I. Focal increases in arterial LDL concentration precede development of fatty streak lesions.

1989 • 272 citations

Two sterol regulatory element-like sequences mediate up-regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol

1997 • 256 citations

Palmitoylation of Endothelial Nitric Oxide Synthase Is Necessary for Optimal Stimulated Release of Nitric Oxide: Implications for Caveolae Localization

1996 • 243 citations

Caveolin mRNA levels are up-regulated by free cholesterol and down-regulated by oxysterols in fibroblast monolayers

1997 • 241 citations

Genetic Ablation of Caveolin-1 Confers Protection Against Atherosclerosis

2003 • 217 citations

Adhesion of Monocytes to Arterial Endothelium and Initiation of Atherosclerosis Are Critically Dependent on Vascular Cell Adhesion Molecule-1 Gene Dosage

2001 • 215 citations

High-Density Lipoproteins and Endothelial Function

2001 • 208 citations

Expression of Caveolin-1 Induces Premature Cellular Senescence in Primary Cultures of Murine Fibroblasts

2002 • 204 citations

Caveolin-1 mediates testosterone-stimulated survival/clonal growth and promotes metastatic activities in prostate cancer cells.

2001 • 193 citations

Localized protein accumulation in the wall of the aorta

1967 • 164 citations

Rosuvastatin Decreases Caveolin-1 and Improves Nitric Oxide–Dependent Heart Rate and Blood Pressure Variability in Apolipoprotein E ^−/− Mice In Vivo

2003 • 163 citations

Simvastatin Improves Disturbed Endothelial Barrier Function

2000 • 147 citations

Transendothelial transport of low density lipoprotein in association with cell mitosis in rat aorta.

1989 • 141 citations

Effect of high-density lipoproteins on the expression of adhesion molecules in endothelial cells

2002 • 139 citations

Antiproliferative action of cyclic GMP-elevating vasodilators in cultured rabbit aortic smooth muscle cells

1989 • 138 citations

Co-expression of scavenger receptor-BI and caveolin-1 is associated with enhanced selective cholesteryl ester uptake in THP-1 macrophages

1999 • 134 citations

Measurement in vivo of irreversible degradation of low density lipoprotein in the rabbit aorta. Predominance of intimal degradation.

1984 • 129 citations

Caveolin-1 expression sensitizes fibroblastic and epithelial cells to apoptotic stimulation

2001 • 127 citations

Caveolin-1 Inhibits Epidermal Growth Factor-stimulated Lamellipod Extension and Cell Migration in Metastatic Mammary Adenocarcinoma Cells (MTLn3)

2000 • 122 citations

HDL Stimulation of Endothelial Nitric Oxide Synthase A Novel Mechanism of HDL Action

2003 • 116 citations

Focal 3H-Cholesterol uptake in the pig aorta

1971 • 108 citations

Intracellular Transport of Low Density Lipoprotein Derived Free Cholesterol Begins at Clathrin-Coated Pits and Terminates at Cell Surface Caveolae

1996 • 98 citations

NITRIC OXIDE ATTENUATES ADHESION MOLECULE EXPRESSION IN HUMAN ENDOTHELIAL CELLS

1996 • 97 citations

The effects of exogenous nitric oxide on smooth muscle cell proliferation following porcine carotid angioplasty

1995 • 97 citations

Endothelial NO Synthase Overexpression Inhibits Lesion Formation in Mouse Model of Vascular Remodeling

2001 • 96 citations

Caveolin-1 Can Regulate Vascular Smooth Muscle Cell Fate by Switching Platelet-Derived Growth Factor Signaling From a Proliferative to an Apoptotic Pathway

2003 • 95 citations

Involvement of caveolin-1 in cholesterol enrichment of high density lipoprotein during its assembly by apolipoprotein and THP-1 cells

2000 • 93 citations

Role of dying endothelial cells in transendothelial macromolecular transport.

1990 • 93 citations

Cellular apoptosis is associated with increased caveolin-1 expression in macrophages

2003 • 91 citations

Regulation of smooth muscle cell growth, function and death in vitro by activated mast cells—a potential mechanism for the weakening and rupture of atherosclerotic plaques

2003 • 81 citations

Stabilization of Caveolin-1 by Cellular Cholesterol and Scavenger Receptor Class B Type I

2002 • 78 citations

Cholesterol efflux from macrophages and other cells

1996 • 78 citations

Influence of caveolin-1 on cellular cholesterol efflux mediated by high-density lipoproteins

2001 • 76 citations

Proatherosclerotic events: pathobiochemical changes occurring in the arterial wall before monocyte migration

1993 • 75 citations

Role of extracellular retention of low density lipoproteins in atherosclerosis

2000 • 74 citations

Caveolin‐1 negatively regulates SR‐BI mediated selective uptake of high‐density lipoprotein‐derived cholesteryl ester

2001 • 70 citations

Caveolae can be alternative endocytotic structures in elicited macrophages.

1997 • 59 citations

Caveolin-1 does not affect SR-BI-mediated cholesterol efflux or selective uptake of cholesteryl ester in two cell lines

2003 • 58 citations

Caveolin-1 and Caveolin-2 Expression in Mouse Macrophages

2001 • 56 citations

Influx, efflux, and accumulation of LDL in normal arterial areas and atherosclerotic lesions of white Carneau pigeons with naturally occurring and cholesterol-aggravated aortic atherosclerosis.

1993 • 44 citations

Hepatic overexpression of caveolins increases bile salt secretion in mice

2003 • 38 citations

Local intimal-medial uptakes of 125I-albumin, 125I-LDL, and parenteral Evans blue dye protein complex along the aortas of normocholesterolemic minipigs as predictors of subsequent hypercholesterolemic atherogenesis.

1993 • 33 citations

Adenovirus-Mediated Expression of Caveolin-1 in Mouse Liver Increases Plasma High-Density Lipoprotein Levels

2001 • 31 citations

Relationship between inhibition of aortic histamine formation, aortic albumin permeability and atherosclerosis

1979 • 28 citations

The Regulation of Caveolin Expression and Localization by Serum and Heparin in Vascular Smooth Muscle Cells

1999 • 27 citations

SR-BI does not require raft/caveola localisation for cholesteryl ester selective uptake in the human adrenal cell line NCI-H295R

2003 • 26 citations

Adenoviral Transfer of Endothelial Nitric Oxide Synthase Attenuates Lesion Formation in a Novel Murine Model of Postangioplasty Restenosis

2003 • 23 citations

Signal Transduction for PDGF‐Induced Chemotaxis of Vascular Smooth Muscle Cells^aa

1997 • 6 citations