Biology of pulmonary preneoplastic lesions

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Cancer Cell Cycles

1996 • 5,379 citations

The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells

1982 • 5,272 citations

“Field cancerization” in oral stratified squamous epithelium. Clinical implications of multicentric origin

1953 • 3,421 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

Tumor Suppressor Genes

1991 • 1,784 citations

Preferential Formation of Benzo[ a ]pyrene Adducts at Lung Cancer Mutational Hotspots in P53

1996 • 1,636 citations

The matrix‐degrading metalloproteinases

1992 • 1,383 citations

Human Proto-Oncogene c- jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1

1987 • 1,353 citations

FUNCTION AND REGULATION OF RAS

1993 • 1,161 citations

Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis.

1989 • 961 citations

Multiplicity generates diversity in the retinoic acid signalling pathways

1992 • 836 citations

Cooperation between oncogenes

1991 • 792 citations

bcl-2 Protein in Non-Small-Cell Lung Carcinoma

1993 • 684 citations

Changes in Bronchial Epithelium in Relation to Cigarette Smoking and in Relation to Lung Cancer

1961 • 625 citations

Analysis of proliferative grade using anti-PCNA/cyclin monoclonal antibodies in fixed, embedded tissues. Comparison with flow cytometric analysis.

1989 • 582 citations

Mutational Activation of the K-rasOncogene

1987 • 542 citations

Microsatellite alterations as clonal markers for the detection of human cancer.

1994 • 448 citations

Telomerase Activity in Small-Cell and Non-Small-Cell Lung Cancers

1995 • 447 citations

The retinoblastoma protein binds to a family of E2F transcription factors.

1993 • 436 citations

Development of carcinoma of the lung as reflected in exfoliated cells

1974 • 422 citations

Detection of oncogene mutations in sputum precedes diagnosis of lung cancer

1994 • 403 citations

Telomeres, Telomerase, and Immortality

1995 • 393 citations

Detection of dysplasia and carcinoma in situ with a lung imaging fluorescence endoscope device

1993 • 390 citations

Clinical significance of ras oncogene activation in human lung cancer

1993 • 361 citations

Allele-Specific Chromosome 3p Deletions Occur at an Early Stage in the Pathogenesis of Lung Carcinoma

1995 • 337 citations

Prognostic significance of p53 mutations and 3p deletions in primary, resected non-small cell lung cancer

1995 • 333 citations

Mechanisms of Apoptosis: Integration of Genetic, Biochemical, and Cellular Indicators

1994 • 320 citations

Mutations of p53 and ras genes in radon-associated lung cancer from uranium miners

1992 • 315 citations

Apoptosis-related factors p53, Bcl2, and Bax in neuroendocrine lung tumors.

1996 • 273 citations

bcl-2: Role in epithelial differentiation and oncogenesis

1996 • 272 citations

Changes in Bronchial Epithelium in Relation to Cigarette Smoking, 1955–1960 vs. 1970–1977

1979 • 262 citations

p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus

1993 • 256 citations

Deletions of 17p and p53 mutations in preneoplastic lesions of the lung.

1992 • 254 citations

Expression of mutated epidermal growth factor receptor by non-small cell lung carcinomas.

1993 • 246 citations

Signal transduction from cell surface to nucleus in development and disease

1992 • 246 citations

Rb and p16INK4a expression in resected non-small cell lung tumors.

1996 • 236 citations

Differential expression of the c-erbB-2 gene in human small cell and non-small cell lung cancer

1990 • 233 citations

Roentgenographically Occult Lung Cancer: Pathologic Findings and Frequency of Multicentricity During a 10-Year Period

1984 • 232 citations

Cancer recurrence after resection: T1 N0 non-small cell lung cancer

1990 • 230 citations

K-ras oncogene activation in atypical alveolar hyperplasias of the human lung.

1996 • 216 citations

Allele-Specific Loss in Chromosome 9p Loci in Preneoplastic Lesions Accompanying Non-Small-Cell Lung Cancers

1995 • 211 citations

p53 Protein accumulates frequently in early bronchial neoplasia

1994 • 211 citations

Three distinct regions involved in 3p deletion in human lung cancer

1993 • 200 citations

Failure of programmed cell death and differentiation as causes of tumors: some simple mathematical models.

1995 • 188 citations

Evidence of cumulative gene losses with progression of premalignant epithelial lesions to carcinoma of the bronchus

1996 • 182 citations

K-ras mutations are a relatively late event in the pathogenesis of lung carcinomas

1995 • 170 citations

Expression of CD44 in human lung tumors

1994 • 165 citations

Bronchioloalveolar Cell Adenomas

1990 • 161 citations

Genetic evidence for an independent origin of multiple preneoplastic and neoplastic lung lesions

1995 • 160 citations

Prognostic impact of mutated K-ras gene in surgically resected non-small cell lung cancer patients

1994 • 156 citations

Aberrant expression of p53 or the epidermal growth factor receptor is frequent in early bronchial neoplasia and coexpression precedes squamous cell carcinoma development.

1995 • 146 citations

Expression of metalloproteinases and their inhibitors in primary pulmonary carcinomas

1992 • 143 citations

The biology of lung cancer.

1993 • 143 citations

Frequent loss of chromosome 9 in human primary non-small cell lung cancer.

1994 • 136 citations

Atypical Adenomatous Hyperplasia and Bronchoalveolar Lung Carcinoma

1996 • 133 citations

Inactivation of the retinoblastoma susceptibility gene in non-small-cell lung cancer. The Lung Cancer Study Group.

1993 • 128 citations

c-K-ras and p53 mutations occur very early in adenocarcinoma of the lung

1995 • 127 citations

Role of the urokinase receptor in facilitating extracellular matrix invasion by cultured colon cancer.

1991 • 123 citations

Detection of K-ras Oncogene Mutations in Bronchoalveolar Lavage Fluid for Lung Cancer Diagnosis

1995 • 118 citations

Cytogenetic abnormalities and overexpression of receptors for growth factors in normal bronchial epithelium and tumor samples of lung cancer patients

1991 • 118 citations

How Cells Cycle Toward Cancer

1994 • 117 citations

Microsatellite alterations in bronchial and sputum specimens of lung cancer patients

1996 • 117 citations

The Molecular Biology of Lung Cancer Pathogenesis

1993 • 116 citations

Altered cJun expression: An early event in human lung carcinogenesis

1996 • 116 citations

TELOMERES AND TELOMERASE IN HUMAN CANCER (REVIEW)

1995 • 106 citations

Allele-specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma

1995 • 101 citations

Concurrent p53 expression in bronchial dysplasias and squamous cell lung carcinomas.

1993 • 99 citations

Genesis of squamous cell lung carcinoma: Sequential changes of proliferation, DNA ploidy, and p53 expression

1995 • 99 citations

Occurrence of Human Papillomavirus DNA in Primary Lung Neoplasms

1992 • 96 citations

Sequential molecular genetic changes in lung cancer development

1996 • 96 citations

Molecular analysis of the von Hippel-Lindau disease tumor suppressor gene in human lung cancer cell lines.

1994 • 96 citations

Proliferative potential and p53 overexpression in precursor and early stage lesions of bronchioloalveolar lung carcinoma.

1995 • 96 citations

Molecular mapping of deletion sites in the short arm of chromosome 3 in human lung cancer

1990 • 94 citations

Alveolar epithelial hyperplasia and adenocarcinoma of the lung.

1990 • 94 citations

The molecular and cellular basis of human lung cancer.

1994 • 93 citations

Three distinct regions involved in 3P deletion in human lung cancer.

1993 • 92 citations

Identification of a novel region of homozygous deletion on chromosome 9p in squamous cell carcinoma of the lung: the location of a putative tumor suppressor gene.

1997 • 92 citations

Cancer of the lung: the cytology of sputum prior to the development of carcinoma.

1965 • 90 citations

Human papillomavirus DNA in squamous cell carcinoma of the lung.

1996 • 87 citations

Atypical alveolar hyperplasia: Relationship with pulmonary adenocarcinoma, p53, and c‐erbB‐2 expression

1994 • 85 citations

High frequency of K‐ras mutations in normal appearing lung tissues and sputum of patients with lung cancer

1995 • 83 citations

Detection of Dysplasia and CarcinomaIn Situby Ratio Fluorometry

1992 • 78 citations

Extensive areas of aneuploidy are present in the respiratory epithelium of lung cancer patients

1996 • 72 citations

Detection of K-ras gene mutations in non-neoplastic lung tissue and lung cancers

1996 • 72 citations

Expression of the BCL-2 protein in normal and dysplastic bronchial epithelium and in lung carcinomas

1995 • 61 citations

p53 expression in normal and dysplastic bronchial epithelium and in lung carcinomas

1994 • 58 citations

P53 in squamous metaplasia: a marker for risk of respiratory tract carcinoma.

1996 • 58 citations

Human non‐small cell lung cancer: P53 protein accumulation is an early event and persists during metastatic progression

1994 • 55 citations

Molecular analysis of the FHIT gene at 3p14.2 in lung cancer cell lines.

1996 • 54 citations

Atypical adenomatous hyperplasia and adenocarcinoma of the human lung: their heterology in form and analogy in immunohistochemical characteristics.

1996 • 54 citations

Changes in the expression of matrix proteases and of the transcription factor c-Ets-1 during progression of precancerous bronchial lesions.

1996 • 52 citations

Frequency and prognostic evaluation of 3p21‐22 allelic losses in non‐small‐cell lung cancer

1995 • 47 citations

Neovascularization in hyperplastic, metaplastic and potentially preneoplastic lesions of the bronchial mucosa

1996 • 46 citations

p53 protein accumulation and the presence of human papillomavirus dna in bronchiolo‐alveolar carcinoma correlate with poor prognosis

1995 • 43 citations

Atypical adenomatous hyperplasia and adenocarcinoma of the human lung: Their heterology in form and analogy in immunohistochemical characteristics

1996 • 42 citations

Neoangiogenesis: A putative marker of malignancy in non-small-cell-lung-cancer (NSCLC) development

1996 • 37 citations

Distribution of peptidyl-glycine alpha-amidating mono-oxygenase (PAM) enzymes in normal human lung and in lung epithelial tumors.

1996 • 37 citations

Squamous metaplasia expression of proto-oncogenes and P 53 in lung cancer patients.

1993 • 35 citations

Clara cell 10 kDa protein mRNA in normal and atypical regions of human respiratory epithelium

1994 • 34 citations

New prognostic factors in resectable non-small cell lung cancer.

1996 • 33 citations

Expression of proliferating cell nuclear antigen (PCNA) in dysplasia of the bronchial epithelium

1993 • 33 citations

Somatic genetic changes in lung cancer and precancerous lesions

1995 • 29 citations

Extracellular Matrix in Preneoplastic Lesions and Early Cancer of the Lung

1990 • 28 citations

Distinct regions of p53 have a differential role in transcriptional activation and repression functions.

1994 • 28 citations

EXPRESSION OF MARKERS OF DIFFERENTIATION IN NORMAL BRONCHIAL EPITHELIUM AND BRONCHIAL DYSPLASIA

1996 • 26 citations

Detection and Sequencing of p53 Gene Mutations in Bronchial Biopsy Samples in Patients With Lung Cancer

1993 • 25 citations

Analysis of K-ras gene mutations in malignant and nonmalignant endobronchial tissue obtained by fiberoptic bronchoscopy.

1995 • 22 citations

Patterns of p53 mutations in squamous cell carcinoma of the lung: Acquisition at a relatively early age

1995 • 19 citations

Biochemical characterization of peptide alpha-amidation enzyme activities of human neuroendocrine lung cancer cell lines.

1993 • 18 citations

Cytokeratin Expression in Preneoplastic Lesions and Early Squamous Cell Carinoma of the Bronchi

1996 • 16 citations

Biopsy Pathology of the Bronchi

1986 • 16 citations

Codon 12 Ki-ras mutation in non-small-cell lung cancer: comparative evaluation in tumoural and non-tumoural lung

1996 • 15 citations

Expression of peptidyl-glycine alpha-amidating mono-oxygenase (PAM) enzymes in morphological abnormalities adjacent to pulmonary tumors.

1996 • 13 citations

Bronchial epithelial changes associated with small cell carcinoma of the lung

1993 • 10 citations

Peptide amidating activity in human bronchoalveolar lavage fluid

1996 • 9 citations

Molecular follow-up of a preinvasive bronchial lesion treated by 13-CIS-retinoic acid

1997 • 8 citations

Biopsy Pathology of the Bronchi

1987 • 4 citations