Genetic evidence for an independent origin of multiple preneoplastic and neoplastic lung lesions

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1953 • 3,421 citations

Monoclonal antibodies against recombinant parts of the Ki‐67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave‐processed formalin‐fixed paraffin sections

1992 • 1,484 citations

Clinical Implications of the p53 Tumor-Suppressor Gene

1993 • 1,341 citations

Increased expression of mutant forms of p53 oncogene in primary lung cancer

1990 • 1,045 citations

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

1990 • 978 citations

K-rasOncogene Activation as a Prognostic Marker in Adenocarcinoma of the Lung

1990 • 811 citations

Clonal Origin of Bladder Cancer

1992 • 538 citations

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1986 • 535 citations

An immunochemical analysis of the human nuclear phosphoprotein p53

1992 • 533 citations

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group.

1990 • 515 citations

Loss of heterozygosity of chromosome 3p markers in small-cell lung cancer

1987 • 472 citations

Deletion of a DNA sequence at the chromosomal region 3p21 in all major types of lung cancer

1987 • 396 citations

Gene p53 mutations are restricted to poorly differentiated and undifferentiated carcinomas of the thyroid gland.

1993 • 375 citations

Adjuvant treatment of stage I lung cancer with high-dose vitamin A.

1993 • 353 citations

Analysis of p53 expression in human tumours: an antibody raised against human p53 expressed in Escherichia coli

1992 • 335 citations

Prognostic significance of p53 mutations and 3p deletions in primary, resected non-small cell lung cancer

1995 • 333 citations

Mutations of p53 and ras genes in radon-associated lung cancer from uranium miners

1992 • 315 citations

p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus

1993 • 256 citations

Deletions of 17p and p53 mutations in preneoplastic lesions of the lung.

1992 • 254 citations

Metachronous multifocal development of urothelial cancers by intraluminal seeding

1993 • 223 citations

Expression of mutated p53 occurs in tumor-distant epithelia of head and neck cancer patients: a possible molecular basis for the development of multiple tumors.

1993 • 200 citations

The p53 gene is very frequently mutated in small-cell lung cancer with a distinct nucleotide substitution pattern

1992 • 199 citations

Cytogenetic abnormalities and overexpression of receptors for growth factors in normal bronchial epithelium and tumor samples of lung cancer patients

1991 • 118 citations

Genetic changes in lung cancer

1993 • 26 citations

Paraffin wax‐embedded material as a source of DNA for the detection of somatic genetic changes

1993 • 9 citations