Expression of the BCL-2 protein in normal and dysplastic bronchial epithelium and in lung carcinomas

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Apoptosis. Its significance in cancer and cancer Therapy

1994 • 2,148 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

Involvement of the bcl -2 Gene in Human Follicular Lymphoma

1985 • 1,797 citations

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.

1991 • 1,301 citations

Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

1986 • 1,232 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.

1986 • 1,118 citations

Bcl-2 initiates a new category of oncogenes: regulators of cell death

1992 • 1,078 citations

Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer.

1992 • 1,063 citations

Bcl-2 initiates a new category of oncogenes: regulators of cell death

1992 • 860 citations

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA

1993 • 758 citations

Identification of a p53-dependent negative response element in the bcl-2 gene.

1994 • 747 citations

bcl-2 Protein in Non-Small-Cell Lung Carcinoma

1993 • 684 citations

Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation.

1990 • 622 citations

bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs.

1992 • 487 citations

Down-regulation of bcl-2 by p53 in breast cancer cells.

1994 • 479 citations

The Bcl-2 Protein: a Prognostic Indicator Strongly Related to p53 Protein in Lymph Node-Negative Breast Cancer Patients

1994 • 461 citations

bcl-2 in normal human breast and carcinoma, association with oestrogen receptor-positive, epidermal growth factor receptor-negative tumours and in situ cancer

1994 • 326 citations

Multiple subcellular localization of bcl-2: detection in nuclear outer membrane, endoplasmic reticulum membrane, and mitochondrial membranes.

1994 • 290 citations

Regulation by bcl-2, c-myc, and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotherapy compounds in differentiation-competent and -defective myeloid leukemic cells.

1993 • 280 citations

BCL‐2 expression in adult and embryonic non‐haematopoietic tissues

1993 • 265 citations

Expression of the apoptosis-suppressing protein bcl-2, in neuroblastoma is associated with unfavorable histology and N-myc amplification.

1993 • 262 citations

p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus

1993 • 256 citations

The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum, and the outer mitochondrial membrane.

1994 • 233 citations

Expression of bcl-2 in small cell lung carcinoma cells.

1994 • 222 citations

Stress-resistance conferred by high level of bcl-2 alpha protein in human B lymphoblastoid cell.

1989 • 216 citations

p53 Protein accumulates frequently in early bronchial neoplasia

1994 • 211 citations

Paradoxical inhibition of solid tumor cell growth by bcl2.

1994 • 190 citations

p53 and bcl-2 expression in high-grade B-cell lymphomas: correlation with survival time

1994 • 188 citations

Involvement of chromosome 7 in primary lung tumor and nonmalignant normal lung tissue

1989 • 131 citations

bcl-2 expression in epidermal keratinocytic diseases

1994 • 131 citations

Bcl‐2 protein expression in carcinomas originating from the follicular epithelium of the thyroid gland

1994 • 126 citations

Cytogenetic abnormalities and overexpression of receptors for growth factors in normal bronchial epithelium and tumor samples of lung cancer patients

1991 • 118 citations

Immunohistochemical detection of p53 and bcl‐2 proteins in non‐Hodgkin's lymphoma

1993 • 101 citations

Concurrent p53 expression in bronchial dysplasias and squamous cell lung carcinomas.

1993 • 99 citations

Genesis of squamous cell lung carcinoma: Sequential changes of proliferation, DNA ploidy, and p53 expression

1995 • 99 citations

Evaluation of bcl-2 protein expression and 14;18 translocation as prognostic markers in follicular lymphoma

1992 • 97 citations

The molecular and cellular basis of human lung cancer.

1994 • 93 citations

Sputum Cytopathology: Use and Potential in Monitoring the Workplace Environment by Screening for Biological Effects of Exposure

1986 • 90 citations

Bcl-2 protein localizes to the chromosomes of mitotic nuclei and is correlated with the cell cycle in cultured epithelial cell lines

1994 • 78 citations

Immunohistochemical evidence of aberrantbcl-2 protein expression in gastric epithelial dysplasia

1994 • 74 citations

BCL-2 proto-oncogene expression in prostate cancer and its relationship to the prostatic neuroendocrine cell.

1994 • 66 citations

p53 expression in normal and dysplastic bronchial epithelium and in lung carcinomas

1994 • 58 citations

Transient mitotic phase localization of bcl-2 oncoprotein in human carcinoma cells and its possible role in prevention of apoptosis.

1994 • 58 citations

Expression of bcl‐2 gene product in neuroblastoma

1994 • 44 citations

Determination of biomarkers for intermediate end points in chemoprevention trials.

1992 • 42 citations

Expression of proliferating cell nuclear antigen (PCNA) in dysplasia of the bronchial epithelium

1993 • 33 citations

Considerations in bringing a cancer biomarker to clinical application.

1992 • 30 citations

New approaches to treating early lung cancer

1993 • 10 citations