c-K-ras and p53 mutations occur very early in adenocarcinoma of the lung

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

K-rasOncogene Activation as a Prognostic Marker in Adenocarcinoma of the Lung

1990 • 811 citations

Mutational Activation of the K-rasOncogene

1987 • 542 citations

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group.

1990 • 515 citations

P53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features

1992 • 448 citations

Clinical significance of ras oncogene activation in human lung cancer

1993 • 361 citations

A dot-blot screening procedure for mutated ras oncogenes using synthetic oligodeoxynucleotides

1986 • 351 citations

Mutations of p53 and ras genes in radon-associated lung cancer from uranium miners

1992 • 315 citations

p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus

1993 • 256 citations

Deletions of 17p and p53 mutations in preneoplastic lesions of the lung.

1992 • 254 citations

ras gene mutations in non-small cell lung cancers are associated with shortened survival irrespective of treatment intent.

1991 • 249 citations

K‐ ras oncogene activation in lung adenocarcinomas from former smokers evidence that K‐ ras mutations are an early and irreversible event in the development of adenocarcinoma of the lung

1993 • 187 citations

Aberrations of the p53 tumor suppressor gene in human non-small cell carcinomas of the lung

1993 • 180 citations

p53 mutations in human lung tumors.

1992 • 177 citations

K-ras oncogene activation in lung adenocarcinomas from former smokers evidence that K-ras mutations are an early and irreversible event in the development of adenocarcinoma of the lung

1993 • 169 citations

ras gene mutations as a prognostic marker in adenocarcinoma of the human lung without lymph node metastasis.

1992 • 168 citations

Genetic Heterogeneity of the c-K-ras Locus in Colorectal Adenomas but not in Adenocarcinomas

1993 • 136 citations

Specific genetic analysis of microscopic tissue after selective ultraviolet radiation fractionation and the polymerase chain reaction.

1992 • 126 citations

Overexpression of the p53 Tumor Suppressor Gene Product in Primary Lung Adenocarcinomas Is Associated with Cigarette Smoking

1993 • 90 citations

Use of the single strand conformation polymorphism technique and PCR to detect p53 gene mutations in small cell lung cancer.

1991 • 83 citations