Extracellular Matrix Selectively Modulates the Response of Mammary Epithelial Cells to Different Soluble Signaling Ligands

The Transcriptional Program in the Response of Human Fibroblasts to Serum

1999 • 1,994 citations

Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTEN

1998 • 1,215 citations

Integrin function: molecular hierarchies of cytoskeletal and signaling molecules.

1995 • 1,202 citations

The Discoidin Domain Receptor Tyrosine Kinases Are Activated by Collagen

1997 • 956 citations

Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins.

1998 • 834 citations

Specificity within the EGF family/ErbB receptor family signaling network

1998 • 804 citations

Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors.

1996 • 769 citations

Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane

1989 • 700 citations

Enhancement of Wound Healing by Topical Treatment with Epidermal Growth Factor

1989 • 673 citations

Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity.

1991 • 659 citations

A family of proteins that inhibit signalling through tyrosine kinase receptors

1997 • 648 citations

Activation of the STAT Signaling Pathway Can Cause Expression of Caspase 1 and Apoptosis

1997 • 525 citations

An Orphan Receptor Tyrosine Kinase Family Whose Members Serve as Nonintegrin Collagen Receptors

1997 • 510 citations

alpha vbeta 3 integrin associates with activated insulin and PDGFbeta receptors and potentiates the biological activity of PDGF

1997 • 493 citations

A Novel Membrane Glycoprotein, SHPS-1, That Binds the SH2-Domain-Containing Protein Tyrosine Phosphatase SHP-2 in Response to Mitogens and Cell Adhesion

1996 • 443 citations

Laminin mediates tissue-specific gene expression in mammary epithelia.

1995 • 397 citations

Protein-tyrosine Phosphatase Shp-2 Regulates Cell Spreading, Migration, and Focal Adhesion

1998 • 390 citations

Association of insulin receptor substrate-1 with integrins

1994 • 362 citations

Expression of extracellular matrix components is regulated by substratum.

1990 • 345 citations

Regulation of Tenascin-C, a Vascular Smooth Muscle Cell Survival Factor that Interacts with the αvβ3 Integrin to Promote Epidermal Growth Factor Receptor Phosphorylation and Growth

1997 • 341 citations

Growth factor activation of MAP kinase requires cell adhesion

1997 • 301 citations

Requirement of basement membrane for the suppression of programmed cell death in mammary epithelium

1996 • 292 citations

The IRS-signalling system during insulin and cytokine action

1997 • 280 citations

Extracellular matrix regulates expression of the TGF-beta 1 gene.

1993 • 260 citations

Extracellular Matrix Regulates Apoptosis in Mammary Epithelium through a Control on Insulin Signaling

1999 • 197 citations

Cell Anchorage Permits Efficient Signal Transduction Between Ras and Its Downstream Kinases

1997 • 192 citations

Control of Integrin Expression by Extracellular Matrix

1995 • 190 citations

Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases

1998 • 180 citations

Intracellular Localization of Phosphatidylinositide 3-kinase and Insulin Receptor Substrate-1 in Adipocytes: Potential Involvement of a Membrane Skeleton

1998 • 169 citations

Dynamics of Insulin Signaling in 3T3-L1 Adipocytes

1998 • 164 citations

The COOH-terminal Tyrosine Phosphorylation Sites on IRS-1 Bind SHP-2 and Negatively Regulate Insulin Signaling

1998 • 159 citations

14-3-3 Protein Binds to Insulin Receptor Substrate-1, One of the Binding Sites of Which Is in the Phosphotyrosine Binding Domain

1997 • 155 citations

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1998 • 155 citations

Stat5 as a Target for Regulation by Extracellular Matrix

1995 • 154 citations

Impaired Integrin-mediated Adhesion and Signaling in Fibroblasts Expressing a Dominant-negative Mutant PTP1B

1998 • 145 citations

Integrin-mediated Tyrosine Phosphorylation of SHPS-1 and Its Association with SHP-2

1998 • 145 citations

Protein-tyrosine Phosphatase α Regulates Src Family Kinases and Alters Cell-Substratum Adhesion

1998 • 137 citations

The Laminin–Nidogen Complex is a Ligand for a Specific Splice Isoform of the Transmembrane Protein Tyrosine Phosphatase LAR

1998 • 134 citations

Epidermal Growth Factor Stimulates Cell Proliferation and Inhibits Functional Differentiation of Mouse Mammary Epithelial Cells in Culture*

1983 • 126 citations

Stimulation of IRS-1-associated Phosphatidylinositol 3-Kinase and Akt/Protein Kinase B but Not Glucose Transport by β1-Integrin Signaling in Rat Adipocytes

1998 • 122 citations

sst2 Somatostatin Receptor Mediates Negative Regulation of Insulin Receptor Signaling through the Tyrosine Phosphatase SHP-1

1998 • 113 citations

p125Fak Focal Adhesion Kinase Is a Substrate for the Insulin and Insulin-like Growth Factor-I Tyrosine Kinase Receptors

1998 • 109 citations

Interaction between the Grb10 SH2 Domain and the Insulin Receptor Carboxyl Terminus

1996 • 100 citations

Regulation of Mammary Differentiation by Extracellular Matrix Involves Protein-tyrosine Phosphatases

1998 • 97 citations

The protein tyrosine phosphatase SHP-1 regulates integrin-mediated adhesion of macrophages

1998 • 92 citations

Extracellular matrix regulates whey acidic protein gene expression by suppression of TGF-alpha in mouse mammary epithelial cells: studies in culture and in transgenic mice.

1995 • 88 citations

Cross-talk between Insulin Receptor and Integrin α5β1 Signaling Pathways

1998 • 82 citations

Quantitative Determination of EGF-R During Epidermal Wound Healing

1992 • 81 citations

Differential Regulation of Protein-tyrosine Phosphatases by Integrin αIIbβ3 through Cytoskeletal Reorganization and Tyrosine Phosphorylation in Human Platelets

1995 • 81 citations

IRS Pleckstrin Homology Domains Bind to Acidic Motifs in Proteins

1998 • 73 citations

A Rho-associated Protein Kinase, ROKα, Binds Insulin Receptor Substrate-1 and Modulates Insulin Signaling

1998 • 69 citations

Calcium-dependent Signaling Pathways in T Cells

1997 • 68 citations

Extracellular matrix modulates epidermal growth factor receptor activation in rat glomerular epithelial cells.

1994 • 66 citations

Differential effects of okadaic acid on insulin-stimulated glucose and amino acid uptake and phosphatidylinositol 3-kinase activity

1993 • 63 citations

Insulin Receptor Substrate-1 as a Signaling Molecule for Focal Adhesion Kinase pp125FAK and pp60

1998 • 63 citations

Gamma-interferon induces an irreversible growth arrest in mid-G1 in mammary epithelial cells which correlates with a block in hyperphosphorylation of retinoblastoma.

1996 • 62 citations

Control of normal mammary epithelial phenotype by integrins.

1998 • 50 citations

Epithelial cell culture

1996 • 36 citations