Activation of Protein Kinase C-ζ and Phosphatidylinositol 3′-Kinase and Promotion of Macrophage Differentiation by Insulin-Like Growth Factor-I

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

Growth Factors and Cancer

1991 • 2,044 citations

Nutritional Regulation of the Insulin-Like Growth Factors*

1994 • 1,537 citations

Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor

1995 • 1,400 citations

Protein kinase C isoenzymes: divergence in signal transduction?

1993 • 1,237 citations

The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression

1987 • 1,180 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

1993 • 966 citations

ESTERASES IN HUMAN LEUKOCYTES

1973 • 905 citations

Stress-Induced Phosphorylation and Activation of the Transcription Factor CHOP (GADD153) by p38 MAP Kinase

1996 • 893 citations

DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1995 • 742 citations

The syntax of immune-neuroendocrine communication

1994 • 720 citations

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1996 • 713 citations

Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques.

1995 • 700 citations

Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways

1997 • 662 citations

Insulin-like growth factor-I is an essential regulator of the differentiation of 3T3-L1 adipocytes.

1988 • 506 citations

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf

1994 • 476 citations

Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase.

1994 • 443 citations

Monoclonal antibodies to receptors for insulin and somatomedin-C.

1983 • 423 citations

Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors

1993 • 380 citations

“Spontaneous” differentiation of skeletal myoblasts is dependent upon autocrine secretion of insulin-like growth factor-II

1991 • 365 citations

Chapter 2 Assays of Cell Viability: Discrimination of Cells Dying by Apoptosis

1994 • 354 citations

ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation.

1996 • 331 citations

Molecular Transductional Mechanisms by which IFNγ and Other Signals Regulate Macrophage Development

1987 • 266 citations

Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat.

1992 • 263 citations

Insulin-Like Growth Factor-I Stimulates Terminal Myogenic Differentiation by Induction of Myogenin Gene Expression

1991 • 258 citations

Insulin-Like Growth Factor Receptors

1991 • 235 citations

Oncogenes and the strategy of growth factors

1994 • 232 citations

Insulin-like growth factor-I inhibits apoptosis in IL-3-dependent hemopoietic cells.

1992 • 225 citations

Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta.

1994 • 221 citations

Insulin-stimulated phosphatidylinositol 3-kinase. Association with a 185-kDa tyrosine-phosphorylated protein (IRS-1) and localization in a low density membrane vesicle.

1993 • 220 citations

The MAP Kinase Pathway Controls Differentiation from Double-Negative to Double-Positive Thymocyte

1996 • 213 citations

Phosphatidylinositol 3-Kinase Inhibitors Block Differentiation of Skeletal Muscle Cells

1996 • 210 citations

Activation of the CPP32 Apoptotic Protease by Distinct Signaling Pathways with Differential Sensitivity to Bcl-xL

1996 • 190 citations

Differential surface expression of cell adhesion molecules during granulocyte maturation

1993 • 188 citations

Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase.

1995 • 184 citations

Opposing early and late effects of insulin-like growth factor I on differentiation and the cell cycle regulatory retinoblastoma protein in skeletal myoblasts.

1995 • 172 citations

Requirement for phosphatidylinositol 3'-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor.

1996 • 171 citations

Quantitation of surface CD14 on human monocytes and neutrophils

1997 • 168 citations

Prolactin, Growth Hormone, and Insulin-like Growth Factor-I in the Immune System

1996 • 168 citations

Enhancement of human granulopoiesis in vitro by biosynthetic insulin-like growth factor I/somatomedin C and human growth hormone.

1988 • 166 citations

Associations between the neuroendocrine and immune systems

1995 • 159 citations

Insulin-like growth factor I shifts from promoting cell division to potentiating maturation during neuronal differentiation.

1991 • 141 citations

Insulin-Like Growth Factor (IGF)-Binding Protein-3 Blocks IGF-I-Induced Receptor Down-Regulation and Cell Desensitization in Cultured Bovine Fibroblasts*

1991 • 130 citations

Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation

1995 • 124 citations

Insulin-like growth factor-1 potentiates expansion of interleukin-7- dependent pro-B cells

1993 • 109 citations

IGF‐II is more active than IGF‐I in stimulating L6A1 myogenesis: Greater mitogenic actions of IGF‐I delay differentiation

1994 • 100 citations

Functional switching of macrophage responses to tumor necrosis factor-alpha (TNF alpha) by interferons. Implications for the pleiotropic activities of TNF alpha.

1994 • 99 citations

Phosphatidylinositol 3-kinase activation in normal human B lymphocytes.

1996 • 72 citations

Expression of leukocyte differentiation antigens during the differentiation of HL-60 cells induced by 1,25-dihydroxyvitamin D3: comparison with the maturation of normal monocytic and granulocytic bone marrow cells

1995 • 72 citations

Transcriptional synergism between the vitamin D3 receptor and other nonreceptor transcription factors.

1994 • 68 citations

Biochemical and pharmacological studies with KT7692 and LY294002 on the role of phosphatidylinositol 3-kinase in FcεRI-mediated signal transduction

1995 • 65 citations

Regulation of Myeloid Growth and Differentiation by the Insulin-Like Growth Factor I Receptor¹

1997 • 64 citations

Phosphatidylinositol 3-kinase related kinases

1996 • 61 citations

Nerve growth factor-induced differentiation of PC12 cells employs the PMA-insensitive protein kinase C-ζ isoform

1994 • 56 citations

The colony-stimulating factors induce expression of insulin-like growth factor-I messenger ribonucleic acid during hematopoiesis.

1995 • 45 citations

Protein kinase C-zeta reverts v-raf transformation of NIH-3T3 cells.

1996 • 43 citations

Insulin-like growth factor-1 increases the mitogenic response of human peripheral blood lymphocytes to phytohemagglutinin

1989 • 37 citations

Insulin-like growth factor-I stimulates c-fos and c-jun transcription in PC12 cells

1994 • 35 citations

Comparative studies of the granulopoietic enhancing effects of biosynthetic human insulin-like growth factors I and II

1993 • 33 citations

Intracellular multiplication of Legionella pneumophila in HL-60 cells differentiated by 1,25-dihydroxyvitamin D3 and the effect of interferon y

1993 • 25 citations

ζPKC in Rat Preadipocytes: Modulation by Insulin and Serum Mitogenic Factors and Possible Role in Adipogenesisϵ

1995 • 18 citations

Insulin-like growth factor-I regulates pro-B cell differentiation

1992 • 16 citations

Expression of c-jun during macrophage differentiation of HL-60 cells

1991 • 2 citations