Effect of rapamycin on the cyclosporin A–resistant CD28-mediated costimulatory pathway

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

1994 • 1,954 citations

TOR, a Central Controller of Cell Growth

2000 • 1,919 citations

Regulation of translation initiation by FRAP/mTOR

2001 • 1,532 citations

RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1994 • 1,470 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

1999 • 964 citations

Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin

1997 • 953 citations

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k

1997 • 930 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

1998 • 872 citations

Isolation of a Protein Target of the FKBP12-Rapamycin Complex in Mammalian Cells

1995 • 859 citations

The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15

1995 • 760 citations

Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.

1990 • 699 citations

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation.

1996 • 671 citations

CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines.

1989 • 662 citations

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

1991 • 660 citations

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

2000 • 656 citations

Cbl-b regulates the CD28 dependence of T-cell activation

2000 • 607 citations

CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells.

1991 • 562 citations

Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12–rapamycinassociated protein

1999 • 490 citations

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex.

1994 • 475 citations

Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15.

1995 • 397 citations

Binding of phosphatidyl-inositol-3-OH kinase to CD28 is required for T-cell signalling

1994 • 378 citations

Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells.

1994 • 367 citations

Stabilization of Interleukin-2 mRNA by the c-Jun NH ₂ -Terminal Kinase Pathway

1998 • 353 citations

Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines

2001 • 322 citations

T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif.

1994 • 291 citations

Inhibition of Cell Cycle Progression by Rapamycin Induces T Cell Clonal Anergy Even in the Presence of Costimulation

1999 • 288 citations

A point mutation in CD28 distinguishes proliferative signals from survival signals

2001 • 210 citations

Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway.

1996 • 167 citations

CD28: a signalling perspective

1996 • 156 citations

Cutting Edge: Distinct Motifs Within CD28 Regulate T Cell Proliferation and Induction of Bcl-XL

2001 • 153 citations

TCR and CD28 Are Coupled Via ZAP-70 to the Activation of the Vav/Rac-1-/PAK-1/p38 MAPK Signaling Pathway

1999 • 148 citations

p70^s6k Integrates Phosphatidylinositol 3-Kinase and Rapamycin-Regulated Signals for E2F Regulation in T Lymphocytes

1999 • 138 citations

The CD28 ligand, B7, enhances IL-2 production by providing a costimulatory signal to T cells.

1992 • 125 citations

Regulation of T-cell lymphokine gene transcription by the accessory molecule CD28.

1992 • 115 citations

Critical Requirement for the Membrane-Proximal Cytosolic Tyrosine Residue for CD28-Mediated Costimulation In Vivo

2001 • 97 citations

Tyrosine-phosphorylated Vav1 as a Point of Integration for T-cell Receptor- and CD28-mediated Activation of JNK, p38, and Interleukin-2 Transcription

2000 • 92 citations

A Putative Sirolimus (Rapamycin) Effector Protein

1994 • 77 citations

Both CD28 ligands CD80 (B7-1) and CD86 (B7-2) activate phosphatidylinositol 3-kinase, and wortmannin reveals heterogeneity in the regulation of T cell IL-2 secretion

1995 • 74 citations

Alterations in NF kappa B/Rel family proteins in splenic T-cells from tumor-bearing mice and reversal following therapy.

1994 • 70 citations

CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase.

1995 • 66 citations

The regulation of p27Kip1 expression following the polyclonal activation of murine G0 T cells.

1997 • 62 citations

Inhibition of calcineurin phosphatase activity in adult bone marrow transplant patients treated with cyclosporine A

1994 • 57 citations

Cross‐linking CD28 leads to activation of 70‐kDa S6 kinase

1994 • 37 citations

Anti-CD28 antibody- and IL-4-induced human T cell proliferation is sensitive to rapamycin

1993 • 28 citations

HIV-Nef enhances interleukin-2 production and phosphatidylinositol 3-kinase activity in a human T cell line

2000 • 27 citations

FK506 and rapamycin selectively enhance degradation of IL-2 and GM-CSF mRNA.

1992 • 21 citations

Opposing effects of rapamycin and cyclosporin A on activation-induced Ca2+ release

1999 • 13 citations

Water insoluble drugs set for oral delivery

1999 • 1 citations