Mechanism of Membrane Binding of the Phospholipase D1 PX Domain

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features

1983 • 14,802 citations

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

The PSIPRED protein structure prediction server

2000 • 3,578 citations

Assessment of protein models with three-dimensional profiles

1992 • 3,317 citations

Techniques of lipidology (isolation, analysis and identification of lipids

1974 • 2,557 citations

Enhanced genome annotation using structural profiles in the program 3D-PSSM 1 1Edited by J. Thornton

2000 • 1,494 citations

[31] PHD: Predicting one-dimensional protein structure by profile-based neural networks

1996 • 1,291 citations

FUGUE: sequence-structure homology recognition using environment-specific substitution tables and structure-dependent gap penalties11Edited by B. Honig

2001 • 1,203 citations

ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity

1993 • 900 citations

Techniques of Lipidology

1973 • 777 citations

Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization

1997 • 698 citations

USE OF SURFACE PLASMON RESONANCE TO PROBE THE EQUILIBRIUM AND DYNAMIC ASPECTS OF INTERACTIONS BETWEEN BIOLOGICAL MACROMOLECULES

1997 • 620 citations

The PX domains of p47phox and p40phox bind to lipid products of PI(3)K

2001 • 600 citations

Characterization of Two Alternately Spliced Forms of Phospholipase D1

1997 • 547 citations

Kinetic analysis of macromolecular interactions using surface plasmon resonance biosensors

1997 • 540 citations

Phospholipase D: molecular and cell biology of a novel gene family

2000 • 495 citations

Exploiting the past and the future in protein secondary structure prediction

1999 • 493 citations

PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox

2001 • 402 citations

Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes

2001 • 362 citations

Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast

1998 • 328 citations

Using multiple structure alignments, fast model building, and energetic analysis in fold recognition and homology modeling

2003 • 314 citations

Mammalian phospholipase D structure and regulation

1999 • 311 citations

Binding of the PX domain of p47phox to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction

2002 • 308 citations

Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3‐kinases: Binding partners of SH3 domains?

1996 • 304 citations

Phospholipase D and Its Product, Phosphatidic Acid, Mediate Agonist-dependent Raf-1 Translocation to the Plasma Membrane and the Activation of the Mitogen-activated Protein Kinase Pathway

1999 • 297 citations

SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P

2001 • 278 citations

The Crystal Structure of the PX Domain from p40phox Bound to Phosphatidylinositol 3-Phosphate

2001 • 273 citations

Phospholipase D1: a key factor for the exocytotic machinery in neuroendocrine cells

2001 • 238 citations

Activation of phospholipase D by protein kinase C. Evidence for a phosphorylation-independent mechanism.

1992 • 237 citations

Phospholipase D—Structure, regulation and function

2007 • 234 citations

Epitope Mapping by Label-Free Biomolecular Interaction Analysis

1996 • 223 citations

Stimulation of actin stress fibre formation mediated by activation of phospholipase D

1996 • 215 citations

Phospholipase D2 Localizes to the Plasma Membrane and Regulates Angiotensin II Receptor Endocytosis

2004 • 211 citations

All Phox Homology (PX) Domains from Saccharomyces cerevisiae Specifically Recognize Phosphatidylinositol 3-Phosphate

2001 • 210 citations

The PX domain: a new phosphoinositide-binding module

2002 • 184 citations

Intracellular Localization of Phospholipase D1 in Mammalian Cells

2001 • 183 citations

Phospholipase D and membrane traffic

1999 • 177 citations

Contrasting Membrane Interaction Mechanisms of AP180 N-terminal Homology (ANTH) and Epsin N-terminal Homology (ENTH) Domains

2003 • 175 citations

Identification of a phosphoinositide binding motif that mediates activation of mammalian and yeast phospholipase D isoenzymes

1999 • 174 citations

Regulation of phospholipase D1 subcellular cycling through coordination of multiple membrane association motifs

2003 • 163 citations

Phosphatidylinositol 3-Phosphate Induces the Membrane Penetration of the FYVE Domains of Vps27p and Hrs

2002 • 161 citations

Differential Roles of Ionic, Aliphatic, and Aromatic Residues in Membrane−Protein Interactions: A Surface Plasmon Resonance Study on Phospholipases A₂

2001 • 150 citations

Phoxy Lipids

2001 • 145 citations

Membrane Binding Mechanisms of the PX Domains of NADPH Oxidase p40 and p47

2003 • 140 citations

Phospholipase D regulation and localisation is dependent upon a phosphatidylinositol 4,5-bisphosphate-specific PH domain

2000 • 137 citations

A Structure-Function Study of the C2 Domain of Cytosolic Phospholipase A2

1999 • 137 citations

The Phox homology (PX) domain, a new player in phosphoinositide signalling

2001 • 128 citations

Phox Homology Domains Specifically Bind Phosphatidylinositol Phosphates

2001 • 125 citations

Membrane Binding Assays for Peripheral Proteins

2001 • 123 citations

Roles of Ionic Residues of the C1 Domain in Protein Kinase C-α Activation and the Origin of Phosphatidylserine Specificity

2001 • 121 citations

Phospholipase D structure and regulation

1999 • 118 citations

Interaction of the Small G Protein RhoA with the C Terminus of Human Phospholipase D1

1999 • 106 citations

Evaluation of protein multiple alignments by SAM-T99 using the BAliBASE multiple alignment test set

2001 • 100 citations

Dual Requirement for Rho and Protein Kinase C in Direct Activation of Phospholipase D1 Through G Protein-coupled Receptor Signaling

2000 • 100 citations

Characterization of a Rat Brain Phospholipase D Isozyme

1998 • 99 citations

The PX Domain as a Novel Phosphoinositide- Binding Module

2001 • 94 citations

The Phox homology (PX) domain, a new player in phosphoinositide signalling

2001 • 90 citations

Phospholipase D activation in fibroblast membranes by the α and β isoforms of protein kinase C

1994 • 90 citations

Phosphorylation and Activation of Phospholipase D1 by Protein Kinase C in Vivo: Determination of Multiple Phosphorylation Sites

1999 • 83 citations

A Role for Phospholipase D in GLUT4 Glucose Transporter Translocation

2000 • 73 citations

Phospholipase D1 and potential targets of its hydrolysis product, phosphatidic acid

2003 • 71 citations

Regulation of Phospholipase D2 Activity by Protein Kinase Cα

2004 • 70 citations

The phosphatidylinositol 3-kinase inhibitor, wortmannin, inhibits insulin-induced activation of phosphatidylcholine hydrolysis and associated protein kinase C translocation in rat adipocytes

1996 • 68 citations

Mechanisms of Regulation of Phospholipase D1 by Protein Kinase Cα

2003 • 68 citations

Phorbol myristate acetate-dependent association of protein kinase Cα with phospholipase D1 in intact cells

1997 • 65 citations

Regulation of human PLD1 and PLD2 by calcium and protein kinase C

2000 • 65 citations

The Role of the Pleckstrin Homology Domain in Membrane Targeting and Activation of Phospholipase Cβ1

2000 • 65 citations

Molecular modeling of the membrane targeting of phospholipase C pleckstrin homology domains

2003 • 63 citations

Scratching the surface with the PH domain

1995 • 62 citations

Phospholipase D1 in Caveolae: Regulation by Protein Kinase Cα and Caveolin-1

1999 • 61 citations

Definition of the Protein Kinase C Interaction Site of Phospholipase D

1998 • 58 citations

The Direct Interaction of Phospholipase C-γ1 with Phospholipase D2 Is Important for Epidermal Growth Factor Signaling

2003 • 55 citations

Structural Basis of Membrane Targeting by the Phox Homology Domain of Cytokine-independent Survival Kinase (CISK-PX)

2004 • 54 citations

Involvement of Phosphatidylinositol 3′‐Kinase in Stem‐Cell‐Factor‐Induced Phospholipase D Activation and Arachidonic Acid Release

1997 • 44 citations

Involvement of phospholipase D in insulin-like growth factor-I-induced activation of extracellular signal-regulated kinase, but not phosphoinositide 3-kinase or Akt, in Chinese hamster ovary cells

2003 • 42 citations

General synthesis of phosphatidylinositol 3-phosphates

1995 • 40 citations

Solution Structure of the Vam7p PX Domain^,

2002 • 36 citations

Immunolocalisation of phospholipase D1 on tubular vesicular membranes of endocytic and secretory origin

2001 • 36 citations

Phospholipase D

1997 • 15 citations