Binding of the PX domain of p47phox to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

Refinement of Macromolecular Structures by the Maximum-Likelihood Method

1997 • 14,729 citations

Techniques of lipidology (isolation, analysis and identification of lipids

1974 • 2,557 citations

Automated protein model building combined with iterative structure refinement.

1999 • 2,428 citations

NADPH Oxidase: An Update

1999 • 2,134 citations

[27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods

1997 • 1,905 citations

Killing activity of neutrophils is mediated through activation of proteases by K+ flux

2002 • 1,141 citations

SH3 domains: complexity in moderation

2001 • 778 citations

The PX domains of p47phox and p40phox bind to lipid products of PI(3)K

2001 • 600 citations

Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities

2000 • 515 citations

PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox

2001 • 402 citations

Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities

2000 • 398 citations

Neutrophil nicotinamide adenine dinucleotide phosphate oxidase assembly. Translocation of p47-phox and p67-phox requires interaction between p47-phox and cytochrome b558.

1991 • 379 citations

The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases.

1994 • 342 citations

Structural Basis for Discrimination of 3-Phosphoinositides by Pleckstrin Homology Domains

2000 • 330 citations

Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase.

1994 • 286 citations

Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targets.

1994 • 285 citations

The Crystal Structure of the PX Domain from p40phox Bound to Phosphatidylinositol 3-Phosphate

2001 • 273 citations

Phosphorylation of neutrophil 47-kDa cytosolic oxidase factor. Translocation to membrane is associated with distinct phosphorylation events.

1990 • 248 citations

Mechanism for Phosphorylation-induced Activation of the Phagocyte NADPH Oxidase Protein p47

1999 • 221 citations

All Phox Homology (PX) Domains from Saccharomyces cerevisiae Specifically Recognize Phosphatidylinositol 3-Phosphate

2001 • 210 citations

Assembly and Activation of the Phagocyte NADPH Oxidase

1996 • 184 citations

Solution structure of the PX domain, a target of the SH3 domain.

2001 • 165 citations

Phosphatidylinositol 3-Phosphate Induces the Membrane Penetration of the FYVE Domains of Vps27p and Hrs

2002 • 161 citations

Architecture of the p40-p47-p67 Complex in the Resting State of the NADPH Oxidase

2002 • 152 citations

Differential Roles of Ionic, Aliphatic, and Aromatic Residues in Membrane−Protein Interactions: A Surface Plasmon Resonance Study on Phospholipases A₂

2001 • 150 citations

Activation of p47 , a Cytosolic Subunit of the Leukocyte NADPH Oxidase

1998 • 141 citations

Mechanisms of NADPH oxidase activation: translocation of p40phox, Rac1 and Rac2 from the cytosol to the membranes in human neutrophils lacking p47phox or p67phox

1996 • 138 citations

Membrane Binding Assays for Peripheral Proteins

2001 • 123 citations

Roles of Ionic Residues of the C1 Domain in Protein Kinase C-α Activation and the Origin of Phosphatidylserine Specificity

2001 • 121 citations

Localization of the 47 kDa phosphoprotein involved in the respiratory-burst NADPH oxidase of phagocytic cells

1989 • 117 citations

Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo

2002 • 115 citations

Phosphatidic Acid and Diacylglycerol Directly Activate NADPH Oxidase by Interacting with Enzyme Components

2001 • 114 citations

The p40 and p47 PX Domains of NADPH Oxidase Target Cell Membranes via Direct and Indirect Recruitment by Phosphoinositides

2002 • 110 citations

Activation of the Phagocyte NADPH Oxidase Protein p47

1999 • 100 citations

Analysis of Activation-induced Conformational Changes in p47 Using Tryptophan Fluorescence Spectroscopy

1997 • 100 citations

Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo

2002 • 95 citations

The PX Domain as a Novel Phosphoinositide- Binding Module

2001 • 94 citations

Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity

2001 • 91 citations

Interactions between the components of the human NADPH oxidase A review about the intrigues in the phox family

1996 • 76 citations

The NADPH Oxidase Components p47phox and p40phox Bind to Moesin through Their PX Domain

2001 • 74 citations

Anionic Amphiphile-independent Activation of the Phagocyte NADPH Oxidase in a Cell-free System by p47 and p67 , Both in C Terminally Truncated Forms

1998 • 72 citations

Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity

2001 • 70 citations

The respiratory burst oxidase of human neutrophils. Guanine nucleotides and arachidonate regulate the assembly of a multicomponent complex in a semirecombinant cell-free system.

1993 • 67 citations

Mechanism for phosphorylation-induced activation of the phagocyte NADPH oxidase protein p47phox

1999 • 60 citations

Activation of Human Neutrophil NADPH Oxidase by Phosphatidic Acid or Diacylglycerol in a Cell-free System

1999 • 59 citations

JFC1, a Novel Tandem C2 Domain-containing Protein Associated with the Leukocyte NADPH Oxidase

2001 • 50 citations

The respiratory burst oxidase of human neutrophils

1990 • 45 citations

Solution Structure of the Vam7p PX Domain^,

2002 • 36 citations

A Phospholipase A2Kinetic and Binding Assay Using Phospholipid-Coated Hydrophobic Beads

1997 • 29 citations

Study of NADPH oxidase-activated sites in human neutrophils

2002 • 27 citations