T Regulatory Type 1 Cells in Squamous Cell Carcinoma of the Head and Neck: Mechanisms of Suppression and Expansion in Advanced Disease

Use of Ranks in One-Criterion Variance Analysis

1952 • 9,960 citations

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

Paradoxical roles of the immune system during cancer development

2006 • 2,213 citations

Head and Neck Cancer

2001 • 1,258 citations

Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans

2006 • 1,156 citations

Induction and mechanism of action of transforming growth factor‐β‐secreting Th3 regulatory cells

2001 • 856 citations

Infectious immunological tolerance.

1971 • 811 citations

Prevalence of FOXP3+ Regulatory T Cells Increases During the Progression of Pancreatic Ductal Adenocarcinoma and Its Premalignant Lesions

2006 • 746 citations

Regulatory T cells in cancer

2006 • 717 citations

Prognostic Value of Tumor-Infiltrating CD4+ T-Cell Subpopulations in Head and Neck Cancers

2006 • 561 citations

Tregs and rethinking cancer immunotherapy

2007 • 532 citations

Tumor-Specific Human CD4+ Regulatory T Cells and Their Ligands

2004 • 525 citations

Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patients with gastric and esophageal cancers.

2003 • 487 citations

Immune suppression in cancer: Effects on immune cells, mechanisms and future therapeutic intervention

2005 • 474 citations

A Unique Subset of CD4+CD25highFoxp3+ T Cells Secreting Interleukin-10 and Transforming Growth Factor-β1 Mediates Suppression in the Tumor Microenvironment

2007 • 429 citations

Cutting Edge: Th17 and Regulatory T Cell Dynamics and the Regulation by IL-2 in the Tumor Microenvironment

2007 • 410 citations

T-cell regulation: with complements from innate immunity

2006 • 334 citations

Expansion of FOXP3high regulatory T cells by human dendritic cells (DCs) in vitro and after injection of cytokine-matured DCs in myeloma patients

2006 • 302 citations

The Frequency and Suppressor Function of CD4+CD25highFoxp3+ T Cells in the Circulation of Patients with Squamous Cell Carcinoma of the Head and Neck

2007 • 273 citations

Characteristics of CD4+CD25+ regulatory T cells in the peripheral circulation of patients with head and neck cancer

2005 • 271 citations

Head and neck cancer: past, present and future

2006 • 252 citations

Immune Escape Associated with Functional Defects in Antigen-Processing Machinery in Head and Neck Cancer

2006 • 213 citations

Natural Regulatory T Cells and De Novo-Induced Regulatory T Cells Contribute Independently to Tumor-Specific Tolerance

2007 • 213 citations

Cutting Edge: OX40 Inhibits TGF-β- and Antigen-Driven Conversion of Naive CD4 T Cells into CD25+Foxp3+ T cells

2007 • 202 citations

Increased frequency of regulatory T cells in peripheral blood and tumour infiltrating lymphocytes in colorectal cancer patients.

2007 • 171 citations

Dendritic Cells and Tumor Microenvironment: A Dangerous Liaison

2006 • 156 citations

Immunobiology of head and neck cancer

2005 • 155 citations

Expression of ICOS on Human Melanoma-Infiltrating CD4+CD25highFoxp3+ T Regulatory Cells: Implications and Impact on Tumor-Mediated Immune Suppression

2008 • 153 citations

Expansion of Human T Regulatory Type 1 Cells in the Microenvironment of Cyclooxygenase 2 Overexpressing Head and Neck Squamous Cell Carcinoma

2007 • 152 citations

Human tumor antigens recognized by T-cells

1997 • 121 citations

Increased Prevalence of Regulatory T Cells (Treg) is Induced by Pancreas Adenocarcinoma

2006 • 113 citations

Immune responses to p53 in patients with cancer:enrichment in tetramer+ p53 peptide-specific T cells and regulatory T cells at tumor sites

2005 • 104 citations

Expansion and characteristics of human T regulatory type 1 cells in co-cultures simulating tumor microenvironment

2007 • 92 citations

Separation of tumor-infiltrating lymphocytes from tumor cells in human solid tumors

1986 • 80 citations

Protective mechanisms of head and neck squamous cell carcinomas from immune assault

2005 • 67 citations

Functional and phenotypic characteristics of CD4⁺CD25^highFoxp3⁺ Treg clones obtained from peripheral blood of patients with cancer

2007 • 61 citations

T-Cell Stimulation and Regulation: With Complements from CD46

2005 • 54 citations

Isolation, Expansion, and Characterization of Human Natural and Adaptive Regulatory T Cells

2007 • 41 citations

Klinische und epidemiologische Daten zu Malignomen des Kopf-Hals-Bereichs

2002 • 39 citations

Mechanisms of T Cell Tolerance and Suppression in Cancer Mediated by Tumor-Associated Antigens and Hormones

2007 • 34 citations

Do Tr1 Cells Play a Role in Immunotherapy?

1999 • 10 citations