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Loss of TGF-β signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation

Data up to Jan 2025

Published2011
Citations155
References53

Total Citations Per Year

Abstract

References (53)

Cancer Statistics, 2010

2010 • 12,557 citations

Cancer Statistics, 2009

2009 • 9,675 citations

Smad-dependent and Smad-independent pathways in TGF-β family signalling

2003 • 5,052 citations

TGFβ in Cancer

2008 • 3,555 citations

Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma

2007 • 2,139 citations

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

2005 • 1,893 citations

Non-Smad pathways in TGF-β signaling

2008 • 1,600 citations

Gr-1+CD115+ Immature Myeloid Suppressor Cells Mediate the Development of Tumor-Induced T Regulatory Cells and T-Cell Anergy in Tumor-Bearing Host

2006 • 1,366 citations

NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1

1999 • 1,282 citations

TGFβ: the molecular Jekyll and Hyde of cancer

2006 • 1,228 citations

Role of tissue stroma in cancer cell invasion

2003 • 1,021 citations

TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression

2010 • 894 citations

TGF-β signaling: positive and negative effects on tumorigenesis

2002 • 830 citations

The regulation of TGFβ signal transduction

2009 • 788 citations

The logic of TGFβ signaling

2006 • 704 citations

High-Risk Human Papillomavirus Affects Prognosis in Patients With Surgically Treated Oropharyngeal Squamous Cell Carcinoma

2006 • 650 citations

Alterations in components of the TGF-β superfamily signaling pathways in human cancer

2005 • 522 citations

p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis

2006 • 418 citations

Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β-induced apoptosis

2004 • 384 citations

Dysregulated molecular networks in head and neck carcinogenesis

2008 • 376 citations

PKB/Akt modulates TGF-β signalling through a direct interaction with Smad3

2004 • 369 citations

Focus on head and neck cancer

2004 • 363 citations

TGF-β switches from tumor suppressor to prometastatic factor in a model of breast cancer progression

2003 • 352 citations

Recent changes in the epidemiology of head and neck cancer

2009 • 346 citations

TGF-β switches from tumor suppressor to prometastatic factor in a model of breast cancer progression

2003 • 314 citations

Tumor-Associated CD8+ T Cell Tolerance Induced by Bone Marrow-Derived Immature Myeloid Cells

2005 • 302 citations

Retracted: Frequent genetic and biochemical alterations of the PI 3‐K/AKT/PTEN pathway in head and neck squamous cell carcinoma

2004 • 235 citations

Transforming growth factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis.

1999 • 221 citations

Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation

2009 • 209 citations

Loss of transforming growth factor-β type II receptor promotes metastatic head-and-neck squamous cell carcinoma

2006 • 197 citations

Overexpression of Transforming Growth Factor β1 in Head and Neck Epithelia Results in Inflammation, Angiogenesis, and Epithelial Hyperproliferation

2004 • 191 citations

Nuclear Factor-κB is an Important Modulator of the Altered Gene Expression Profile and Malignant Phenotype in Squamous Cell Carcinoma

2004 • 163 citations

Activation of p53-Dependent Growth Suppression in Human Cells by Mutations in PTEN or PIK3CA

2006 • 157 citations

Loss of PTEN Expression as a Prognostic Marker for Tongue Cancer

2001 • 126 citations

Transforming Growth Factor–β Regulates Mammary Carcinoma Cell Survival and Interaction with the Adjacent Microenvironment

2008 • 124 citations

Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response

2008 • 104 citations

Chemoprevention and Treatment of Experimental Cowden's Disease by mTOR Inhibition with Rapamycin

2008 • 101 citations

Transforming Growth Factor β Induces Apoptosis through Repressing the Phosphoinositide 3-Kinase/AKT/Survivin Pathway in Colon Cancer Cells

2008 • 98 citations

Suppressor and oncogenic roles of transforming growth factor-β and its signaling pathways in tumorigenesis

2001 • 97 citations

TGFβ signaling in head and neck squamous cell carcinoma

2010 • 97 citations

Transforming Growth Factor-β Can Suppress Tumorigenesis through Effects on the Putative Cancer Stem or Early Progenitor Cell and Committed Progeny in a Breast Cancer Xenograft Model

2007 • 94 citations

Somatic Acquisition and Signaling of <EMPH TYPE="ITAL">TGFBR1</EMPH>*6A in Cancer

2005 • 94 citations

Progressive Tumor Formation in Mice with Conditional Deletion of TGF-β Signaling in Head and Neck Epithelia Is Associated with Activation of the PI3K/Akt Pathway

2009 • 90 citations

Mutational analysis of thePTEN gene in head and neck squamous cell carcinoma

1998 • 80 citations

Novel inactivating mutations of transforming growth factor-? type I receptor gene in head-and-neck cancer metastases

2001 • 75 citations

Id-1 activates Akt-mediated Wnt signaling and p27Kip1 phosphorylation through PTEN inhibition

2008 • 69 citations

Frequent Alterations of Smad Signaling in Human Head and Neck Squamous Cell Carcinomas: A Tissue Microarray Analysis

2003 • 64 citations

Induction of p16ink4a and p19ARF by TGFβ1 contributes to growth arrest and senescence response in mouse keratinocytes

2008 • 56 citations

Akt Activation Synergizes with Trp53 Loss in Oral Epithelium to Produce a Novel Mouse Model for Head and Neck Squamous Cell Carcinoma

2009 • 53 citations

Molecular mechanisms of head and neck cancer

2008 • 48 citations

The Cancer Stem Cell Concept in Progression of Head and Neck Cancer

2009 • 46 citations

Attenuated Transforming Growth Factor β Signaling Promotes Nuclear Factor-κB Activation in Head and Neck Cancer

2009 • 35 citations

Genotypic analysis of tumor suppressor genes PTEN/MMAC1 and p53 in head and neck squamous cell carcinomas

1998 • 29 citations

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Loss of TGF-β signaling and PTEN promotes head and neck squamous cell carcinoma through… (2011) – Oncogene | Metascience Observatory Explorer