Mononuclear Phagocytes at the Blood–Brain Barrier in Multiple Sclerosis

Defining the clinical course of multiple sclerosis

1996 • 3,606 citations

Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination

2000 • 3,258 citations

Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity

1991 • 2,806 citations

VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site

1990 • 1,836 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin

1992 • 1,711 citations

Identification of the haemoglobin scavenger receptor

2001 • 1,610 citations

The Heterogeneity of Mononuclear Phagocytes in Lymphoid Organs: Distinct Macrophage Subpopulations in Rat Recognized by Monoclonal Antibodies ED1, ED2 and ED3

1985 • 1,605 citations

Perivascular Microglial Cells of the CNS Are Bone Marrow-Derived and Present Antigen in Vivo

1988 • 1,451 citations

Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration

1998 • 1,356 citations

BREAKDOWN OF THE BLOOD-BRAIN BARRIER PRECEDES SYMPTOMS AND OTHER MRI SIGNS OF NEW LESIONS IN MULTIPLE SCLEROSIS

1990 • 571 citations

The role of magnetic resonance techniques in understanding and managing multiple sclerosis

1998 • 553 citations

Cannabinoids control spasticity and tremor in a multiple sclerosis model

2000 • 526 citations

Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages.

1990 • 511 citations

Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeleton

2000 • 502 citations

Interaction of Junctional Adhesion Molecule with the Tight Junction Components ZO-1, Cingulin, and Occludin

2000 • 469 citations

Junctional Adhesion Molecule Interacts with the PDZ Domain-containing Proteins AF-6 and ZO-1

2000 • 426 citations

The blood-brain barrier in neuroinflammatory diseases.

1997 • 406 citations

Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. Characterization and comparison with tumor necrosis factor.

1991 • 375 citations

Immune Invasion of the Central Nervous System Parenchyma and Experimental Allergic Encephalomyelitis, But Not Leukocyte Extravasation from Blood, Are Prevented in Macrophage-Depleted Mice

1998 • 344 citations

The pathogenesis of lesions and normal-appearing white matter changes in multiple sclerosis: A serial diffusion MRI study

2000 • 314 citations

Structural and signalling molecules come together at tight junctions

1999 • 306 citations

Lymphocyte Migration Through Brain Endothelial Cell Monolayers Involves Signaling Through Endothelial ICAM-1 Via a Rho-Dependent Pathway

1999 • 299 citations

Adhesion molecule expression and regulation on cells of the central nervous system

1999 • 295 citations

Leukocyte Recruitment in the Cerebrospinal Fluid of Mice with Experimental Meningitis Is Inhibited by an Antibody to Junctional Adhesion Molecule (Jam)

1999 • 288 citations

Antibodies to CD44 and integrin α₄, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment

1999 • 287 citations

The contribution of magnetic resonance imaging to the diagnosis of multiple sclerosis

1999 • 286 citations

Robert Feulgen Lecture 1998

1999 • 284 citations

Identity of ED2‐positive perivascular cells in rat brain

1989 • 281 citations

Progress in determining the causes and treatment of multiple sclerosis

1999 • 280 citations

Post-mortem MRI-guided sampling of multiple sclerosis brain lesions: Increased yield of active demyelinating and (p)reactive lesions

2001 • 278 citations

Switched at birth: a new family for PECAM-1

1999 • 257 citations

ICAM-1 Signaling Pathways Associated with Rho Activation in Microvascular Brain Endothelial Cells

1998 • 252 citations

Regulation of CD163 on human macrophages: cross-linking of CD163 induces signaling and activation

1999 • 220 citations

Differential adhesion molecule requirements for immune surveillance and inflammatory recruitment

2000 • 218 citations

DURATION AND SELECTIVITY OF BLOOD-BRAIN BARRIER BREAKDOWN IN CHRONIC RELAPSING EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS STUDIED BY GADOLINIUM-DTPA AND PROTEIN MARKERS

1990 • 215 citations

The effects of macrophage depletion on the clinical and pathologic expression of experimental allergic encephalomyelitis.

1981 • 215 citations

The role of macrophages, perivascular cells, and microglial cells in the pathogenesis of experimental autoimmune encephalomyelitis

1995 • 213 citations

Interleukin-1beta -induced changes in blood-brain barrier permeability, apparent diffusion coefficient, and cerebral blood volume in the rat brain: a magnetic resonance study.

2000 • 212 citations

In vivo macrophage activity imaging in the central nervous system detected by magnetic resonance

1999 • 208 citations

The development of experimental autoimmune encephalomyelitis in the mouse requires alpha4-integrin but not alpha4beta7-integrin.

1998 • 204 citations

Interleukin-1β-Induced Changes in Blood–Brain Barrier Permeability, Apparent Diffusion Coefficient, and Cerebral Blood Volume in the Rat Brain: A Magnetic Resonance Study

2000 • 190 citations

Interferon-β directly influences monocyte infiltration into the central nervous system

2002 • 179 citations

Lymphocyte adhesion and transendothelial migration in the central nervous system: the role of LFA-1, ICAM-1, VLA-4 and VCAM-1. off.

1995 • 178 citations

Involvement of specific macrophage-lineage cells surrounding arterioles in barrier and scavenger function in brain cortex.

1996 • 178 citations

Perivascular cells act as scavengers in the cerebral perivascular spaces and remain distinct from pericytes, microglia and macrophages

1993 • 174 citations

T cell interaction with ICAM-1-deficient endotheliumin vitro: essential role for ICAM-1 and ICAM-2 in transendothelial migration of T cells

1998 • 174 citations

Lymphocyte Migration Through Monolayers of Endothelial Cell Lines Involves VCAM-1 Signaling Via Endothelial Cell NADPH Oxidase

2000 • 173 citations

E- and P-Selectin Are Not Involved in the Recruitment of Inflammatory Cells Across the Blood-Brain Barrier in Experimental Autoimmune Encephalomyelitis

1997 • 171 citations

Expression of immunologically relevant endothelial cell activation antigens on isolated central neurvous system microvessels from patients with multiple sclerosis

1994 • 170 citations

Macrophage phagocytosis of myelin in vitro determined by flow cytometry: phagocytosis is mediated by CR3 and induces production of tumor necrosis factor-α and nitric oxide

1996 • 164 citations

Mechanisms of inflammation in MS tissue: adhesion molecules and chemokines

1999 • 163 citations

VLA-4 integrin can mediate CD11/CD18-independent transendothelial migration of human monocytes.

1993 • 163 citations

In Vitro Adhesion and Migration of T Lymphocytes Across Monolayers of Human Brain Microvessel Endothelial Cells: Regulation by ICAM-1, VCAM-1, E-selectin and PECAM-1

1999 • 160 citations

Reactive oxygen species enhance the migration of monocytes across the blood‐brain barrier in vitro

2001 • 160 citations

Reactive oxygen species are involved in the pathogenesis of experimental allergic encephalomyelitis in Lewis rats

1995 • 156 citations

Interaction of α4-integrin with VCAM-1 is involved in adhesion of encephalitogenic T cell blasts to brain endothelium but not in their transendothelial migration in vitro

2000 • 143 citations

ICAM-1 expression in autoimmune encephalitis visualized using magnetic resonance imaging

2000 • 142 citations

Comparison of ultrasmall particles of iron oxide (USPIO)-enhanced T2-weighted, conventional T2-weighted, and gadolinium-enhanced T1-weighted MR images in rats with experimental autoimmune encephalomyelitis.

1999 • 140 citations

Inhibition of Monocyte/Macrophage Migration to a Spinal Cord Injury Site by an Antibody to the Integrin αD: A Potential New Anti-inflammatory Treatment

2000 • 136 citations

Macrophages in Multiple Sclerosis

1996 • 135 citations

Ligation of ICAM-1 on endothelial cells leads to expression of VCAM-1 via a nuclear factor-kappaB-independent mechanism.

1999 • 134 citations

Monocytes use either CD11/CD18 or VLA-4 to migrate across human endothelium in vitro.

1994 • 128 citations

Randomized trial comparing two different high doses of methylprednisolone in MS A clinical and MRI study

1998 • 127 citations

Characterization of MRI response to treatment with interferon beta-1b: Contrast-enhancing MRI lesion frequency as a primary outcome measure

1997 • 124 citations

Aggravation of experimental allergic encephalomyelitis (EAE) by administration of nitric oxide (NO) synthase inhibitors

1996 • 124 citations

In vivo and in vitro treatment with the synthetic cannabinoid CP55,940 decreases the in vitro migration of macrophages in the rat: involvement of both CB1 and CB2 receptors

2000 • 122 citations

Bothanti-CD11a(LFA-l) and anti-CD11b (MAC-1) therapy delay the onset and diminish the severity of experimental autoimmune encephalomyelitis

1995 • 120 citations

Demonstration of interleukin-1β in Lewis rat brain during experimental allergic encephalomyelitis by immunocytochemistry at the light and ultrastructural level

1993 • 119 citations

The p38 Mitogen-Activated Protein Kinase Mediates Cytoskeletal Remodeling in Pulmonary Microvascular Endothelial Cells Upon Intracellular Adhesion Molecule-1 Ligation

2001 • 117 citations

Characterization and Expression of the Antigen Present on Resident Rat Macrophages Recognized by Monoclonal Antibody ED2

1990 • 114 citations

Discordant effects of anti–VLA-4 treatment before and after onset of relapsing experimental autoimmune encephalomyelitis

2001 • 113 citations

Macrophages in T cell line-mediated, demyelinating, and chronic relapsing experimental autoimmune encephalomyelitis in Lewis rats

1995 • 113 citations

A new primate model for multiple sclerosis in the common marmoset

2000 • 112 citations

Ligation of ICAM-1 on Endothelial Cells Leads to Expression of VCAM-1 Via a Nuclear Factor-κB-Independent Mechanism

1999 • 103 citations

Immunohistological analysis of macrophages in the central nervous system of Lewis rats with acute experimental allergic encephalomyelitis

1986 • 102 citations

PATTERNS OF BLOOD-BRAIN BARRIER BREAKDOWN IN INFLAMMATORY DEMYELINATION

1991 • 100 citations

Treatment with anti‐CR3 antibodies ED7 and ED8 suppresses experimental allergic encephalomyelitis in Lewis rats

1993 • 96 citations

In vivo MRI and its histological correlates in acute adoptive transfer experimental allergic encephalomyelitis

1996 • 95 citations

Insights into the aetiology and pathogenesis of multiple sclerosis

1998 • 90 citations

Dexanabinol (HU-211) effect on experimental autoimmune encephalomyelitis: implications for the treatment of acute relapses of multiple sclerosis

2000 • 79 citations

Interaction of CD163 with the regulatory subunit of casein kinase II (CKII) and dependence of CD163 signaling on CKII and protein kinase C

2001 • 70 citations

The cellular immunology of multiple sclerosis

1999 • 68 citations

The length of treatment determines whether IFN-beta prevents or aggravates experimental autoimmune encephalomyelitis in Lewis rats.

1996 • 68 citations

Factors controlling T-cell migration across rat cerebral endothelium in vitro

1997 • 66 citations

Adhesion Molecule Mechanisms Mediating Monocyte Migration Through Synovial Fibroblast and Endothelium Barriers: Role for CD11/CD18, Very Late Antigen-4 (CD49d/CD29), Very Late Antigen-5 (CD49e/CD29), and Vascular Cell Adhesion Molecule-1 (CD106)

1998 • 57 citations

PECAM-1 (CD31) expression in the central nervous system and its role in experimental allergic encephalomyelitis in the rat

1996 • 56 citations

Lymphocyte adhesion to brain capillary endothelial cells in vitro

1994 • 53 citations

The blood-brain barrier and multiple sclerosis

1994 • 46 citations

Basic mechanisms of brain inflammation

1997 • 43 citations

Magnetic resonance imaging investigation of blood-brain barrier damage in adoptive transfer experimental autoimmune encephalomyelitis

1993 • 41 citations

Cross-Linking of Brain Endothelial Intercellular Adhesion Molecule (ICAM)-1 Induces Association of ICAM-1 With Detergent-Insoluble Cytoskeletal Fraction

2001 • 38 citations

Beneficial effect of modified peptide inhibitor of α4 integrins on experimental allergic encephalomyelitis in Lewis rats

2001 • 37 citations

Extracellular matrix proteins expressed by human adult astrocytes in vivo and in vitro: An astrocyte surface protein containing the CS1 domain contributes to binding of lymphoblasts

1997 • 36 citations

In vivo dynamic MR imaging of MBP‐induced acute experimental allergic encephalomyelitis in Lewis rat

1992 • 33 citations

Role of the leukocyte-adhesion molecule L-selectin in experimental autoimmune encephalomyelitis

1998 • 23 citations

Contrasting effects of anti-adhesion molecule therapy in experimental allergic encephalomyelitis and Theiler's murine encephalomyelitis

1999 • 18 citations

ED2-positive perivascular phagocytes produce interleukin-1? during delayed neuronal loss in the facial nucleus of the rat

1998 • 13 citations

Inhibition of Experimental Allergic Encephalomyelitis with an Antibody that Recognizes a Novel Antigen Expressed on Lymphocytes, Endothelial Cells, and Microglia

2000 • 9 citations